| 赵润芝,张 皓,袁姝华,陈 佳,唐铭钰,孙克兴.桑贝止咳方联合西医常规疗法治疗小儿耐药性肺炎支原体肺炎疗效观察[J].现代生物医学进展英文版,2020,(15):2868-2871. |
| 桑贝止咳方联合西医常规疗法治疗小儿耐药性肺炎支原体肺炎疗效观察 |
| Clinical Observation of SangBeiZhiKe Granula Combined with Routine Western Medicine in the Treatment of Macrolide Resistant Mycoplasma Pneumoniae Pneumonia in Children |
| Received:February 06, 2020 Revised:February 28, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.15.013 |
| 中文关键词: 耐药性肺炎支原体肺炎 桑贝止咳方 中医证候积分 |
| 英文关键词: Macrolide-Resistant Mycoplasma Pneumoniae Pneumonia SangBeiZhiKe Granula The scores of TCM syndromes |
| 基金项目:上海市科学技术委员会项目（19401931800）；上海交通大学医学院项目（18zxy007） |
| Author Name | Affiliation | E-mail | | ZHAO Run-zhi | Department of Traditional Chinese Medicine, Shanghai Children's Medical Center affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China | zrunzhi@126.com | | ZHANG Hao | Department of respiratory, Shanghai Children's Medical Center affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China | | | YUAN Shu-hua | Department of respiratory, Shanghai Children's Medical Center affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China | | | CHEN Jia | Department of Traditional Chinese Medicine, Shanghai Children's Medical Center affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China | | | TANG Ming-yu | Department of respiratory, Shanghai Children's Medical Center affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China | | | SUN Ke-xing | Department of Traditional Chinese Medicine, Shanghai Children's Medical Center affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China | |
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| 中文摘要: |
| 摘要 目的：探究桑贝止咳方联合西医常规疗法治疗小儿耐药性肺炎支原体肺炎患者（Mycoplasma pneumoniae pneumonia, MPP）的临床疗效。方法：选取2018年3月至2019年8月期间我院收治的64例耐药性肺炎支原体肺炎的患者，按照随机数字表法将患儿分为治疗组(n=32)和对照组(n=32)，对照组给予西医常规治疗，治疗组在对照组基础上加服桑贝止咳方治疗。两组疗程均为14 d，随访14 d，观察两组治疗对患儿发热、咳嗽、咯痰等症状的改善程度、比较中医证候积分、退热时间、缩短咳嗽及啰音持续时间的情况。结果：（1）治疗组有效率显著高于对照组[90.6 %（29/32）VS75.0 %（24/32）]，差异有统计学意义（P<0.05）。（2）治疗后，两组的退热时间、咳嗽消失时间及啰音持续时间均低于治疗前，且治疗组以上指标改善程度明显优于对照组[（2.78±0.71）天vs（3.75±1.08）天，（10.31±2.1）天vs（15.03±4.45）天vs(6.34±1.20）天vs（8.53±1.54）天]（P<0.05）；治疗后治疗组中医证候积分（咳嗽、咯痰、便秘、出汗）均显著低于对照组[（0.31±0.74）vs（2.59±0.50），（0.06±0.35）vs(1.88±0.87），(0.09±0.3)vs (0.75±1.08)，( 0.34±0.83)vs(1.65±1.12) ]（P<0.05）。结论：桑贝止咳方联合西医常规疗法治疗小儿耐药性肺炎支原体肺炎患儿疗效显著，能够明显加快临床症状的恢复，促进患者的康复。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of SangBeiZhiKe granula combined with routine western medicine therapy in children with mycoplasma pneumoniae pneumonia. Methods: Sixty-four children who were diagnosed as macrolide-resistant mycoplasma pneumoniae pneumonia in our hospital from March 2018 to August 2019 were selected. The patients were divided into treatment group(n=32) and control group(n=32). The treatment group was given SangBeiZhiKe Granula combined with routine western medicine therapy while the control group was only given routine western medicine treatment. With a treatment course of 14 days and follow-up of 14 days. The clinical efficacy was observed, the scores of TCM syndromes, the Antifebrile time, time for cough to disappear and rale vanishing time were compared between the two groups. Results: After treatment, The clinical effective rate of observation group was significantly higher than that control group[90.6%(29/32) vs 75.0%(24/32)] (P<0.05). The Antifebrile time, the time for cough to disappear and rales vanishing time in the treatment group were all shorter than those in the control group[(2.78±0.71)d vs(3.75±1.08)d, (10.31±2.1)d vs(15.03±4.45)d, (6.34±1.20)d vs(8.53±1.54)d]（P<0.05）; The levels of cough, Cough up phlegm, Astriction, Perspire were significantly lower than those of the control group[(0.31±0.74)vs(2.59±0.50), (0.06±0.35) vs (1.88±0.87), (0.09±0.30) vs(0.75±1.08), (0.34±0.83) vs (1.65±1.12)](P<0.05). Conclusion: SangBeiZhiKe Granula is effective in treatment of children's mycoplasma pneumoniae and promote rehabilitation of patients. |
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