| 秦文波,黄 寨,黄 鹏,陆 政,莫祖聪,李家鑫.右美托咪定联合丙泊酚在缓解ICU病人谵妄及提高其依从性效果探究[J].现代生物医学进展英文版,2020,(14):2786-2789. |
| 右美托咪定联合丙泊酚在缓解ICU病人谵妄及提高其依从性效果探究 |
| Dexmedetomidine Combined with Propofol in Alleviating Delirium and Improving Compliance in ICU Patients |
| Received:March 05, 2020 Revised:March 28, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.14.041 |
| 中文关键词: 右美托咪定 丙泊酚 ICU 谵妄 依从性 |
| 英文关键词: Dexmedetomidine Propofol ICU Delirium Compliance |
| 基金项目:广西壮族自治区卫生和计划生育委员会自筹经费科研项目（Z2016589 ） |
| Author Name | Affiliation | E-mail | | QIN Wen-bo | Department of Critical Care Medicine, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China | qin1977wenbo@163.com | | HUANG Zhai | Department of Critical Care Medicine, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China | | | HUANG Peng | Department of Critical Care Medicine, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China | | | LU Zheng | Department of Critical Care Medicine, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China | | | MO Zu-cong | Department of Critical Care Medicine, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China | | | LI Jia-xin | Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China | |
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| 中文摘要: |
| 摘要 目的：探讨右美托咪定联合丙泊酚在缓解ICU病人谵妄及提高其依从性效果。方法：选取2017年1月-2020年1月我院所收治的79例ICU病人，按治疗方法分为研究组（n=40）和对照组(n=39)，研究组采取右美托咪定联合丙泊酚治疗，对照组采取丙泊酚治疗，对比两种治疗方法对缓解ICU病人谵妄及提高其依从性的影响。结果：研究组患者的见效时间短，丙泊酚用量少，苏醒时间短，阻滞完善时间短，拔管时间短，相比于对照组，镇静效果明显优于对照组（P＜0.05）；研究组患者谵妄发生率明显低于对照组（P＜0.05）；研究组患者的依从性明显高于对照组（P＜0.05）；研究组患者各项生活质量评分指标均明显优于对照组，生活质量总评分明显高于对照组（P＜0.05）。结论：右美托咪定联合丙泊酚具有良好的镇静作用，可有效缓解ICU病人谵妄，并有助于提高患者的依从性，提升患者的生活质量，可作为一种理想的治疗药物推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of dexmedetomidine combined with propofol on relieving delirium and improving compliance in ICU patients. Methods: A total of 79 ICU patients admitted in our hospital from January 2017 to January 2020 were divided into study group (n =40) and control group (n=39) by treatment methods. Patients in study group were treated with dexmedetomidine combined with propofol, The control group patients to take propofol treatment, compared with the two treatment methods to relieve ICU patients delirium and improve their compliance. Results: The study group of patients with short duration of action, less dosage of propofol, wake time is short, block a short time, extubation time is short, compared with the control group, the sedation effect was significantly better than the control group (P<0.05). The incidence of delirium in the study group was significantly lower than that in the control group (P<0.05). The compliance of the study group was significantly higher than that of the control group (P<0.05). The quality of life scores of the study group obviously superior to the control group, the total quality of life score was significantly higher than the control group (P<0.05). Conclusion: Dexmedetomidine combined with propofol has an important sedative effect, which can effectively relieve the delirium of ICU patients, improve patient compliance and improve the quality of life of patients, and can be used as an ideal therapeutic drug. |
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