| 宋 莎,刘 勇,张彬霞,滕 灿,赵思思.低强度脉冲超声波联合股四头肌肌力强化训练治疗膝骨关节炎患者的临床疗效观察[J].现代生物医学进展英文版,2020,(14):2668-2671. |
| 低强度脉冲超声波联合股四头肌肌力强化训练治疗膝骨关节炎患者的临床疗效观察 |
| Clinical Efficacy Observation of Low Intensity Pulse Ultrasound Combined with Quadriceps Femoris Muscle Strength Intensive Training in the Treatment of Patients with Knee Osteoarthritis |
| Received:December 29, 2019 Revised:January 25, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.14.014 |
| 中文关键词: 低强度脉冲 超声波 股四头肌 强化训练 膝骨关节炎 临床疗效 |
| 英文关键词: Low intensity pulse Ultrasound Quadriceps femoris muscle Strength intensive training Knee osteoarthritis Clinical efficacy |
| 基金项目:重庆市卫生和计划生育委员会医学科研计划面上项目（2017MSXM1281） |
| Author Name | Affiliation | E-mail | | SONG Sha | Department of Pain Rehabilitation Medicine, The Second Affiliated Hospital of PLA Army Medical University, Chongqing, 400037, China | songsa555@163.com | | LIU Yong | Department of Pain Rehabilitation Medicine, The Second Affiliated Hospital of PLA Army Medical University, Chongqing, 400037, China | | | ZHANG Bin-xia | Department of Pain Rehabilitation Medicine, The Second Affiliated Hospital of PLA Army Medical University, Chongqing, 400037, China | | | TENG Can | Department of Pain Rehabilitation Medicine, The Second Affiliated Hospital of PLA Army Medical University, Chongqing, 400037, China | | | ZHAO Si-si | Department of Pain Rehabilitation Medicine, The Second Affiliated Hospital of PLA Army Medical University, Chongqing, 400037, China | |
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| 中文摘要: |
| 摘要 目的：观察低强度脉冲超声波联合股四头肌肌力强化训练治疗膝骨关节炎（KOA）患者的临床疗效。方法：选取我院于2016年1月~2018年1月收治的98例KOA患者。根据乱数表法将其分为研究组（n=49，低强度脉冲超声波联合股四头肌肌力强化训练治疗）、对照组（n=49，常规物理治疗）。比较两组临床疗效、Lysholm评分、膝关节日常活动能力（ADL）评分、视觉模拟评分量表（VAS）评分以及滑液中白介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、血管内皮生长因子（VEGF）水平及不良反应。结果：研究组的临床总有效率为91.84%（45/49），高于对照组的69.39%（34/49）（P<0.05）。治疗8周后，两组ADL、VAS评分均降低，且研究组较对照组低（P<0.05）；两组Lysholm评分均升高，且研究组较对照组高（P<0.05）；两组滑液中IL-1β、TNF-α、VEGF水平均降低，且研究组低于对照组（P<0.05）。两组均未见严重的不良反应。结论：低强度脉冲超声波联合股四头肌肌力强化训练治疗KOA患者，可迅速改善患者症状，提高膝关节功能，同时可改善滑液中IL-1β、TNF-α、VEGF水平，具有一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the clinical efficacy of low intensity pulse ultrasound combined with quadriceps femoris muscle strength intensive training in the treatment of patients with knee osteoarthritis (KOA). Methods: 98 patients with KOA who were admitted to our hospital from January 2016 to January 2018 were selected. According to the method of random number table, the patients were divided into study group(n=49, low-intensity pulse ultrasound combined with quadriceps muscle strength strengthening training) and control group (n=49, conventional physical therapy). The clinical efficacy, Lysholm score, daily activity of knee joint(ADL) score, visual analog scale (VAS) score, interleukin-1β(IL-1β) in synovial fluid, tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF), adverse reactions were compared between the two groups. Results: The total effective rate of the study group was 91.84% (45/49), which was higher than that of the control group 69.39% (34/49) (P<0.05). 8 weeks after treatment, the scores of ADL and VAS decreased in both groups, and those of study group were lower than those of the control group (P<0.05); the scores of Lysholm increased in both groups, and that of the study group was higher than that of the control group (P<0.05); the levels of IL-1β, TNF-α and VEGF in synovial fluid of the two groups decreased, and those of study group the study group were lower than those of the control group (P<0.05). There were no serious adverse reactions in both groups. Conclusion: Low intensity pulse ultrasound combined with quadriceps femoris muscle strength intensive training is effective in the treatment of KOA. It can improve the symptoms and knee joint function of KOA patients rapidly, and improve the levels of IL-1β, TNF-α and VEGF in synovial fluid. It has certain clinical application value. |
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