| 罗业姣,龚仁国,陈 齐,张 静,王君莲.口炎清颗粒对慢性牙周炎患者牙周症状及炎性细胞因子水平的影响[J].现代生物医学进展英文版,2020,(13):2537-2540. |
| 口炎清颗粒对慢性牙周炎患者牙周症状及炎性细胞因子水平的影响 |
| Effect of Kouyanqing Granule on Periodontal Symptoms and Inflammatory Cytokines Levels in Patients with Chronic Periodontitis |
| Received:November 22, 2019 Revised:December 17, 2019 |
| DOI：10.13241/j.cnki.pmb.2020.13.029 |
| 中文关键词: 口炎清颗粒 慢性牙周炎 牙周症状 炎性细胞因子 疗效 |
| 英文关键词: Kouyanqing granule Chronic periodontitis Periodontal symptoms Inflammatory cytokines Curative effect |
| 基金项目:四川省教育厅科研项目（18ZA0156） |
| Author Name | Affiliation | E-mail | | LUO Ye-jiao | Department of Stomatology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China | luoyj7261@163.com | | GONG Ren-guo | Department of Stomatology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China | | | CHEN Qi | Department of Stomatology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China | | | ZHANG Jing | Department of Stomatology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China | | | WANG Jun-lian | Department of Stomatology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China | |
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| 中文摘要: |
| 摘要 目的：探讨口炎清颗粒对慢性牙周炎患者牙周症状及炎性细胞因子水平的影响。方法：选取我院2017年3月~2019年3月间收治的94例慢性牙周炎患者作为研究对象，按随机数字表法将患者分为对照组（n=47）和观察组（n=47）。对照组给予常规治疗，观察组在常规治疗基础上联合口炎清颗粒治疗，两组均治疗1个月。治疗后评价两组疗效，观察两组治疗过程中出现的不良反应。检测所有患者治疗前后的牙龈指数（GI）、菌斑指数（PLI）、牙周探诊深度（PD）、临床附着水平（CAL），以及龈沟液中的白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）以及白细胞介素-17（IL-17）水平。结果：观察组总有效率为93.62%，高于对照组的82.98%（P<0.05）。两组不良反应发生率比较无统计学差异（P>0.05）。治疗后，两组GI、PLI、PD、CAL均明显降低，且观察组GI、PLI、PD、CAL明显低于对照组，差异均具有统计学意义（P<0.05）。治疗后，两组IL-1?茁、IL-6、IL-17水平均明显降低，且观察组IL-1β、IL-6、IL-17水平明显低于对照组，差异均具有统计学意义（P<0.05）。结论：口炎清颗粒治疗慢性牙周炎疗效确切，能明显改善牙周症状，降低炎性细胞因子水平，且安全性良好。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of Kouyanqing granule on periodontal symptoms and inflammatory cytokines levels in patients with chronic periodontitis. Methods: 94 patients with chronic periodontitis admitted to our hospital from March 2017 to March 2019 were selected as the subjects of study. Patients were divided into control group (n=47) and observation group (n=47) according to random number table method. The control group was given routine treatment, while the observation group was treated with Kouyanqing granule on the basis of routine treatment, both groups were treated for one month. After treatment, the efficacy of the two groups was evaluated, and the adverse reactions in the course of treatment were observed. The levels of gingival index (GI), plaque index (PLI), probing depth (PD), clinical attachment level (CAL), interleukin-1β (IL-1 beta), interleukin-6 (IL-6) and interleukin-17 (IL-17) in gingival crevicular fluid were measured before and after treatment. Results: The total effective rate of the observation group was 93.62%, higher than 82.98% of the control group (P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups (P>0.05). After treatment, The levels of GI, PLI, PD and CAL in the two groups were significantly decreased, and GI, PLI, PD and CAL in the observation group were significantly lower than those in the control group, the difference was statistically significant (P<0.05). After treatment, the levels of IL-1β, IL-6 and IL-17 in the two groups were significantly decreased, and the levels of IL-1β, IL-6 and IL-17 in the observation group were significantly lower than those in the control group, the difference was statistically significant(P<0.05). Conclusion: Kouyanqing granule is effective in treating chronic periodontitis. It can significantly improve periodontal symptoms and reduce the level of inflammatory cytokines with good safety. |
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