| 罗晶晶,洪乔军,周道平,孙成龙,程先平.肺癌患者生活质量调查及化疗期间发生抑郁的影响因素分析[J].现代生物医学进展英文版,2020,(13):2512-2515. |
| 肺癌患者生活质量调查及化疗期间发生抑郁的影响因素分析 |
| Quality of Life Survey of Lung Cancer Patients and Analysis of Influencing Factors of Depression During Chemotherapy |
| Received:February 17, 2020 Revised:March 12, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.13.023 |
| 中文关键词: 肺癌 化疗 生活质量 抑郁 危险因素 |
| 英文关键词: Lung cancer Chemotherapy Quality of life Depression Risk factors |
| 基金项目:安徽省高等自然科学研究重点项目（KJ2018A0813） |
| Author Name | Affiliation | E-mail | | LUO Jing-jing | Department of Oncology, Anhui Second People's Hospital, Hefei, Anhui, 230041, China | LJJluo138@163.com | | HONG Qiao-jun | Department of Oncology, Anhui Second People's Hospital, Hefei, Anhui, 230041, China | | | ZHOU Dao-ping | Department of Oncology, Anhui Second People's Hospital, Hefei, Anhui, 230041, China | | | SUN Cheng-long | Department of Oncology, Anhui Second People's Hospital, Hefei, Anhui, 230041, China | | | CHENG Xian-ping | Department of Oncology, Anhui Second People's Hospital, Hefei, Anhui, 230041, China | |
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| 中文摘要: |
| 摘要 目的：探讨肺癌患者化疗前后生活质量的变化及化疗期间发生抑郁的影响因素。方法：将2015年1月～2019年12月我院收治的80例肺癌患者纳入研究。所有患者均接受化疗干预，采用健康状况调查简表（SF-36）评分评估患者化疗前后生活质量，以抑郁自评量表（SDS）评估患者抑郁发生情况。对肺癌患者化疗期间发生抑郁的影响因素进行单因素以及多因素Logistic回归分析。结果：化疗后患者的各项生活质量评分均低于化疗前（P＜0.05）。80例肺癌患者化疗期间出现46例抑郁症，抑郁症发生率为57.50%。经单因素分析发现：性别、受教育程度、家庭月收入、疼痛程度、知晓病情均与肺癌患者化疗期间发生抑郁有关（P＜0.05）。经多因素Logistic回归分析可得：女性、家庭月收入＜2500元、Ⅰ度及以上疼痛、知晓病情均是肺癌患者化疗期间发生抑郁的独立危险因素（OR=7.295、1.692、3.952、4.015，P＜0.05）。结论：化疗会在一定程度上降低肺癌患者的生活质量，同时会增加患者抑郁症发生风险，女性、家庭月收入＜2500元、Ⅰ度及以上疼痛、知晓病情均是肺癌患者化疗期间发生抑郁的独立危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the changes in quality of life of lung cancer patients before and after chemotherapy and the influencing factors of depression during chemotherapy. Methods: 80 lung cancer patients who were admitted to our hospital from January 2015 to December 2019 were included in the study. All patients were treated with chemotherapy intervention, and their quality of life before and after chemotherapy was evaluated by health status survey (SF-36) score, and the occurrence of depression was evaluated by depression self-rating scale (SDS). Univariate and multivariate Logistic regression analysis were performed to analyze the influencing factors of depression in lung cancer patients during chemotherapy. Results: All the qol scores after chemotherapy were lower than those before chemotherapy (P＜0.05). There were 46 cases of depression in 80 cases of lung cancer patients during chemotherapy, and the incidence of depression was 57.50%. Univariate analysis showed that gender, education level, family monthly income, pain level and disease awareness were all associated with depression in lung cancer patients during chemotherapy (P＜0.05). The multivariate Logistic regression analysis available: female, family monthly income < 2500 yuan, pain Ⅰ degree and above, disease awareness are independent risk factors for lung cancer during chemotherapy in patients with depression occur (OR=7.295, 1.692, 3.952, 4.015, P＜0.05). Conclusion: Chemotherapy can reduce the quality of life of patients with lung cancer to some extent, can increase the risk of patients with depression occur at the same time, female, family monthly income < 2500 yuan, pain Ⅰ degree and above, disease awareness are independent risk factors for lung cancer patients with depression occurs during chemotherapy. |
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