| 李 平,贺仲晨,李昌祁,姚 丽,肖丽英.钠-葡萄糖转移蛋白抑制剂2治疗糖尿病合并牙周病的临床观察[J].现代生物医学进展英文版,2020,(13):2479-2482. |
| 钠-葡萄糖转移蛋白抑制剂2治疗糖尿病合并牙周病的临床观察 |
| The Elinical Effect of Sodium Glucose Transfer Protein Inhibitor 2 in the Treatment of Diabetes Mellitus with Periodontal Disease Observation |
| Received:February 28, 2020 Revised:March 23, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.13.016 |
| 中文关键词: 钠-葡萄糖转移蛋白抑制剂2 牙周病 糖脂代谢 2型糖尿病 |
| 英文关键词: SGLT2 Periodontal Glycolipid metabolism Type 2 diabetes mellitus |
| 基金项目: |
| Author Name | Affiliation | E-mail | | LI Ping | Department of Stomatology, the Third Affiliated Hospital of Beijing University of traditional Chinese medicine, Beijing, 100029, China | lp_cd_1021@163.com | | HE Zhong-chen | Department of Endocrinology, Hepingli hospital, Beijing, 100021, China | | | LI Chang-qi | Department of Endocrinology, Hepingli hospital, Beijing, 100021, China | | | YAO Li | Department of Stomatology, Hepingli hospital, Beijing, 100021, China | | | XIAO Li-ying | West China College of Stomatology, Chengdu, Sichuan, 610041, China | |
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| 中文摘要: |
| 摘要 目的：探讨钠-葡萄糖转移蛋白酶抑制剂2对2型糖尿病（T2DM）伴牙周病患者疗效。方法：选择近三年来北京中医药大学第三附属医院、北京市和平里医院口腔科收治的72例T2DM伴牙周病为研究对象，观察组（A组）患者行牙周基础治疗并加用列净类药物，对照组（B组）40例患者接受牙周基础治疗加用磺脲类降糖药物。两组治疗前及治疗后3个月牙周探诊深度（I'D）、龈沟出血指数（SBI）、附着丧失（AL）值、空腹血糖CFPG）糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三脂（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、内脂素、瘦素及肿瘤坏死因子（TNF）-α水平的变化。结果：治疗后，两组FPG、HbA1c水平比较差异无统计学意义（P>0.05）；观察组TC、TG、LDL及HDL均显著低于对照组（P<0.05）血清内脂素、瘦素及TNF-α水平均高于对照组(P<0.05)。结论：钠-葡萄糖转移蛋白酶抑制剂2可显著改善T2DM伴牙周病患者的糖脂代谢紊乱水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the therapeutic effect of sodium glucotransferase inhibitor 2 on type 2 diabetes mellitus (T2DM) patients with periodontal disease. Methods: 372 cases of T2DM patients with periodontal disease admitted to the stomatology department of the Third Affiliated Hospital of Beijing University of traditional Chinese medicine and Beijing Hepingli hospital in the past three years were selected as the study object. The patients in the observation group (group A) were treated with periodontal basic treatment and added with detergent drugs. 40 patients in the control group (group B) received basic periodontal treatment plus sulfonylurea. The depth of periodontal exploration (I'd) before and after treatment (3 months), sulcus bleeding index (SBI), attachment loss (AL), fasting blood glucose (cfpg), glycohemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), endolipid, leptin and tumor necrosis factor(TNF-α) - or. Results: there was no significant difference in the FPG, HbA1c between the two groups(P>0.05). The serum levels of TC, TG, LDL and HDL were significantly lower than those in the control group(P<0.05), and the serum levels of lipoproteins, leptin and TNF-α water were significantly higher than those in the control group (P<0.05). Conclusion: Sodium glucotransferase inhibitor 2 can significantly improve the glycolipid metabolism disorder in T2DM patients with periodontal disease. |
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