| 杜喜维,杨瑞霞,晋亚楠,孙 宝,杨 越,曹小雨,赵 宏.白蛋白静脉滴注联合茵栀黄颗粒治疗新生儿黄疸血清 AKP、TBA、 FFA、γ-GT、HS-CRP的影响[J].现代生物医学进展英文版,2020,(11):2152-2155. |
| 白蛋白静脉滴注联合茵栀黄颗粒治疗新生儿黄疸血清 AKP、TBA、 FFA、γ-GT、HS-CRP的影响 |
| Effect of Albumin Intravenous Drip Combined with Yinzhihuang Granule on Serum AKP, TBA, FFA, Gamma-GT and HS-CRP in Neonates with Jaundice |
| Received:October 27, 2019 Revised:November 23, 2019 |
| DOI：10.13241/j.cnki.pmb.2020.11.033 |
| 中文关键词: 新生儿黄疸 白蛋白 茵栀黄颗粒 血清学指标 |
| 英文关键词: Neonatal jaundice Albumin Yinzhihuang granules Serological indicators |
| 基金项目:陕西省科技厅基金项目（2017SF-093） |
| Author Name | Affiliation | E-mail | | DU Xi-wei | Department of Pharmacy, The Second Affiliated Hospital of Xi'an Medical College, Xi'an, Shaanxi, 710038, China | duxiw1234@163.com | | YANG Rui-xia | Department of Pharmacy, The Second Affiliated Hospital of Xi'an Medical College, Xi'an, Shaanxi, 710038, China | | | JIN Ya-nan | Department of Pharmacy, The Second Affiliated Hospital of Xi'an Medical College, Xi'an, Shaanxi, 710038, China | | | SUN Bao | Department of Pharmacy, The Second Affiliated Hospital of Xi'an Medical College, Xi'an, Shaanxi, 710038, China | | | YANG Yue | Department of Pharmacy, The Second Affiliated Hospital of Xi'an Medical College, Xi'an, Shaanxi, 710038, China | | | CAO Xiao-yu | Department of Pharmacy, The Second Affiliated Hospital of Xi'an Medical College, Xi'an, Shaanxi, 710038, China | | | ZHAO Hong | Department of Neonatology, Xi'an XD Group Hospital, Xi'an, Shaanxi, 710077, China | |
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| 中文摘要: |
| 摘要 目的：研究白蛋白静脉滴注联合茵栀黄颗粒对新生儿黄疸血清碱性磷酸酶（alkaline phosphatase，AKP）、总胆汁酸（totalbileacids，TBA）、游离脂肪酸（free fatty acid，FFA）、γ-谷氨酰基转移酶（γ-glutamyltransferase，γ-GT）、超敏 C-反应蛋白（hypersensitive C-reactive protein, HS-CRP）的影响。方法：选择2016年1月～2019年1月我院收治的95例新生儿病理性黄疸患儿，随机分为两组。对照组服用茵栀黄颗粒治疗，观察组在服用茵栀黄的基础上静脉滴注白蛋白治疗。检测两组的血清间接胆红素（indirectreacting bilirubin,，IBIL）、总胆红素（total bilirubin，TBIL）和AKP、TBA、FFA、y-GT、HS-CRP水平。结果：观察组的有效率明显高于对照组（P<0.05）；两组治疗后的血清IBIL、TBIL水平明显降低（P<0.05），观察组的IBIL、TBIL水平明显低于对照组（P<0.05）；两组治疗后的血清AKP、TBA、 FFA、γ-GT、HS-CRP水平明显降低（P<0.05），观察组的血清AKP、TBA、 FFA、γ-GT、HS-CRP水平明显低于对照组（P<0.05）。结论：白蛋白静脉滴注联合茵栀黄颗粒对新生儿黄疸的治疗效果良好，有助于促进血清胆红素和其他血清学相关指标恢复正常，且安全性好。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effects of intravenous albumin infusion combined with Yinzhihuang Granule on serum alkaline phosphatase (AKP), totalbileacids (TBA), free fatty acid (FFA), γ-glutamyltransferase (γ-GT) and hypersensitive C-reactive protein (HS-CRP) in neonates with jaundice. Methods: 95 children with neonatal jaundice to our hospital from January 2016 to January 2019, divided into two groups randomly. The control group was treated with Yinzhihuang Granule, and the observation group was treated with intravenous drip of albumin on the basis of Yinzhihuang. Indirect reactive bilirubin (IBIL), total bilirubin (TBIL), and AKP, TBA, FFA, y-GT, and HS-CRP levels were measured in two groups. Results: The effective rate of the observation group was significantly higher than control group (P<0.05). After treatment, the levels of IBIL and TBIL in the two groups decreased significantly (P<0.05), and the observation group were significantly lower than those in the control group(P<0.05). The serum AKP, TBA, FFA, gamma-GT and HS-CRP levels in the two groups were significantly decreased after treatment(P<0.05), and the serum AKP, TBA, FFA, gamma-GT and HS-CRP levels in the observation group were significantly lower than those in the control group(P<0.05). Conclusion: Albumin combined with Yinzhihuang Granule has a good therapeutic effect on neonatal jaundice, which is helpful to promote the recovery of serum bilirubin and other serological related indicators, and has good safety. |
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