| 闫杰松,李志勇,周 栋,汤祥瑞,郭宏毅.贝那普利联合氨氯地平对高血压患者降压效果、血压变异性及心功能的影响[J].现代生物医学进展英文版,2020,(7):1335-1338. |
| 贝那普利联合氨氯地平对高血压患者降压效果、血压变异性及心功能的影响 |
| Effect of Benazepril Combined with Amlodipine on Blood Pressure Reduction Effect, Blood Pressure Variability and Cardiac Function in Patients with Hypertension |
| Received:July 31, 2019 Revised:August 27, 2019 |
| DOI：10.13241/j.cnki.pmb.2020.07.029 |
| 中文关键词: 贝那普利 氨氯地平 高血压 降压 血压变异性 心功能 |
| 英文关键词: Benazepril Amlodipine Hypertension Hypotension Blood pressure variability Cardiac function |
| 基金项目:陕西省科技计划项目（2016B1210） |
| Author Name | Affiliation | E-mail | | YAN Jie-song | Department of Cardiovascular Medicine, 3201 Hospital Affiliated to Medical College of Xi'an Jiaotong University, Hanzhong, Shaanxi, 723000, China | yk83111@163.com | | LI Zhi-yong | Department of Cardiovascular Medicine, Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China | | | ZHOU Dong | Department of Cardiovascular Medicine, 3201 Hospital Affiliated to Medical College of Xi'an Jiaotong University, Hanzhong, Shaanxi, 723000, China | | | TANG Xiang-rui | Department of Cardiovascular Medicine, 3201 Hospital Affiliated to Medical College of Xi'an Jiaotong University, Hanzhong, Shaanxi, 723000, China | | | GUO Hong-yi | Department of Cardiovascular Medicine, 3201 Hospital Affiliated to Medical College of Xi'an Jiaotong University, Hanzhong, Shaanxi, 723000, China | |
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| 中文摘要: |
| 摘要 目的：探讨贝那普利联合氨氯地平对高血压患者降压效果、血压变异性（BPV）及心功能的影响。方法：选取2015年2月~2018年12月期间西安交通大学医学院附属三二〇一医院收治的131例高血压患者，根据随机数字表法分为对照组（n=65）和研究组（n=66），对照组患者给予氨氯地平治疗，研究组在对照组基础上联合贝那普利治疗。比较两组患者治疗后的降压效果、BPV以及心功能指标，记录两组患者治疗期间不良反应情况。结果：两组患者治疗4个月后收缩压（SBP）、舒张压（DBP）均下降，且研究组低于对照组（P<0.05）。两组患者治疗4个月后24 h收缩压变异性（24hSBPV）、白天收缩压变异性（dSBPV）、24h舒张压变异性（24hDBPV）、白天舒张压变异性（dDBPV）均下降，且研究组低于对照组（P<0.05），而夜间收缩压变异性（nSBPV）、夜间舒张压变异性（nDBPV）比较差异无统计学意义（P>0.05）。两组患者治疗4个月后A峰速度、A/E 峰值均下降，且研究组低于对照组（P<0.05）。两组患者治疗4个月后E峰速度、EF值均升高，且研究组高于对照组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：贝那普利联合氨氯地平治疗高血压患者的降压效果确切，可有效改善患者BPV及心功能，且安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of benazepril combined with amlodipine on blood pressure reduction effect, blood pressure variability (BPV) and cardiac function in patients with hypertension. Methods: 131 hypertensive patients who were admitted to 3201 Hospital Affiliated to Medical College of Xi'an Jiaotong University from February 2015 to December 2018 were selected as the research subjects. All patients were divided into control group (n=65) and study group (n=66) according to random number table method. The control group was treated with amlodipine, and the study group was treated with benazepril on the basis of the control group. The blood pressure reduction effect, BPV and cardiac function were compared between the two groups, and adverse reactions during treatment were recorded between the two groups. Results: 4 months after treatment, systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased in both groups, and those in the study group were lower than those in the control group (P<0.05). 24h systolic blood pressure variability (24hSBPV), daytime systolic blood pressure variability (dSBPV), 24h diastolic blood pressure variability (24hDBPV), daytime diastolic blood pressure variability (dDBPV) of the two groups decreased at 4 months after treatment, and those of the study group were lower than those of the control group (P<0.05). There was no significant difference in night systolic pressure variability (nSBPV) and night diastolic pressure variability (nDBPV) (P>0.05). 4 months after treatment, A peak velocity and A/E peak of the two groups decreased, and those of the study group were lower than those of the control group (P<0.05). The E peak velocity and EF value of the two groups increased at 4 months after treatment, and those of the study group were higher than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Benazepril combined with amlodipine in the treatment of hypertension has definite antihypertensive effect, it can effectively improve BPV and cardiac function, and it does not increase the incidence of adverse reactions, and the safety is better. |
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