| 孙 冰,林玉宽,武玉俐,安 琳,李 翠.甘精胰岛素联合门冬胰岛素对2型糖尿病患者脂糖代谢及生存质量的影响[J].现代生物医学进展英文版,2020,(6):1107-1110. |
| 甘精胰岛素联合门冬胰岛素对2型糖尿病患者脂糖代谢及生存质量的影响 |
| Effects of Insulin Glargine Combined with Insulin Aspart on Lipid and Glucose Metabolism and Guality of Life in Patients with Type 2 Diabetes Mellitus |
| Received:June 23, 2019 Revised:July 18, 2019 |
| DOI：10.13241/j.cnki.pmb.2020.06.024 |
| 中文关键词: 甘精胰岛素 门冬胰岛素 2型糖尿病 血糖 血脂 生存质量 |
| 英文关键词: Insulin glargine Insulin aspart Type 2 diabetes Blood glucose Blood lipid Quality of life |
| 基金项目:北京市科技计划项目（Z1611003942203） |
| Author Name | Affiliation | E-mail | | SUN Bing | Department of Internal Medicine, Beijing Rectum Hospital, Beijing, 100120, China | sunbin13651347882@163.com | | LIN Yu-kuan | Second Department of Internal Medicine, Beijing Xicheng District Guangwai Hospital, Beijing 100120, China | | | WU Yu-li | Beijing Xicheng District zhanlanlu Community Health Service Center, Beijing, 100120, China | | | AN Lin | Department of Internal Medicine, The Second Hospital of Beijing, Beijing, 100120, China | | | LI Cui | Department of Internal Medicine, Beijing Rectum Hospital, Beijing, 100120, China | |
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| 中文摘要: |
| 摘要 目的：探讨甘精胰岛素联合门冬胰岛素对2型糖尿病（T2DM）患者脂糖代谢及生存质量的影响。方法：选取T2DM患者97例，根据随机数字表法将患者分为对照组（n=48）与研究组（n=49），对照组给予门冬胰岛素治疗，研究组在对照组基础上联合甘精胰岛素治疗，比较两组治疗前后血糖指标、血脂指标、生存质量情况，记录两组治疗期间不良反应情况。结果：两组患者治疗后空腹血糖（FBG）、餐后2 h血糖（2hPBG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三酯（TG）以及低密度脂蛋白胆固醇（LDL-C）水平均较治疗前下降，研究组低于对照组（P<0.05）。两组患者治疗后心理评分、生理评分、社会关系评分、治疗依从性评分均较治疗前升高，且研究组高于对照组（P<0.05）。研究组不良反应总发生率低于对照组（P<0.05）。结论：甘精胰岛素联合门冬胰岛素可有效改善T2DM患者血糖、血脂水平，安全性较好，可提高患者生存质量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of insulin glargine combined with insulin aspart on lipid and glucose metabolism and quality of life in patients with type 2 diabetes mellitus (T2DM). Methods: 97 patients with T2DM were selected, which were divided into control group (n=48) and research group (n=49) according to the random number table method. The control group was treated with insulin aspart, while the research group was treated with insulin glargine on the basis of the control group. The levels of blood glucose indexes, blood lipid indexes and quality of life in two groups before and after treatment were compared, adverse reactions during treatment were recorded. Results: After treatment, the levels of fasting blood glucose (FBG), postprandial 2 h blood glucose (2hPBG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) of the patients in the two groups all decreased compared with those before treatment, and the levels in the study group were lower than those in the control group (P<0.05). Psychological score, physiological score, social relationship score and treatment compliance score of the two groups were higher than those before treatment, and the study group was higher than the control group(P<0.05). The total incidence of adverse reactions in the research group was lower than that in the control group(P<0.05). Conclusion: Insulin glargine combined with insulin aspart can effectively improve blood glucose and lipid levels in patients with T2DM and the quality of life of patients with good safety, which can improve the quality of life of patients. |
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