| 徐 伟,李 佳,张黎姣,全军承,卢玉宝.乌司他丁联合连续性血液净化治疗重症急性胰腺炎的疗效及对炎性因子和T细胞亚群的影响[J].现代生物医学进展英文版,2020,(6):1083-1086. |
| 乌司他丁联合连续性血液净化治疗重症急性胰腺炎的疗效及对炎性因子和T细胞亚群的影响 |
| Effects of Ulinastatin Combined with Continuous Blood Purification on Inflammatory Factors and T Cell Subsets in Severe Acute Pancreatitis |
| Received:August 09, 2019 Revised:August 31, 2019 |
| DOI：10.13241/j.cnki.pmb.2020.06.018 |
| 中文关键词: 乌司他丁 连续性血液净化 重症急性胰腺炎 疗效 炎性因子 T细胞亚群 |
| 英文关键词: Ulinastatin Continuous blood purification Severe acute pancreatitis Efficacy Inflammatory factors T cell subsets |
| 基金项目:重庆市医学科研基金项目（2015A031761） |
| Author Name | Affiliation | E-mail | | XU Wei | Emergency Intensive Care Unit, The Second Affiliated Hospital of Army Medical University, Chongqing, 400037, China | weiwork123@sohu.com | | LI Jia | Emergency Intensive Care Unit, The Second Affiliated Hospital of Army Medical University, Chongqing, 400037, China | | | ZHANG Li-jiao | Emergency Intensive Care Unit, The Second Affiliated Hospital of Army Medical University, Chongqing, 400037, China | | | QUAN Jun-cheng | Emergency Intensive Care Unit, The Second Affiliated Hospital of Army Medical University, Chongqing, 400037, China | | | LU Yu-bao | Emergency Intensive Care Unit, The Second Affiliated Hospital of Army Medical University, Chongqing, 400037, China | |
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| 中文摘要: |
| 摘要 目的：探讨乌司他丁联合连续性血液净化（CBP）治疗重症急性胰腺炎（SAP）的疗效及对炎性因子和T细胞亚群的影响。方法：选取2016年5月~2018年9月期间我院收治的SAP患者117例，根据随机数字表法将患者分为对照组（n=58）和研究组（n=59），对照组在基础对症治疗的基础上给予乌司他丁治疗，研究组在对照组基础上联合CBP治疗，比较两组临床疗效、临床各项指标改善情况、炎性因子以及T细胞亚群。结果：研究组治疗后临床总有效率为66.10%（39/59），高于对照组患者的46.55%（27/58）（P<0.05）。研究组住院时间、血淀粉酶恢复正常时间、症状缓解时间均短于对照组（P<0.05）。两组患者治疗后血清白介素-6（IL-6）、白介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）水平均较治疗前降低，且研究组低于对照组（P<0.05）。两组患者治疗后CD4+、CD4+/CD8+均较治疗前升高，且研究组高于对照组（P<0.05），CD8+较治疗前降低，且研究组低于对照组（P<0.05）。结论：乌司他丁联合CBP治疗SAP患者，疗效显著， 可有效改善患者临床症状，提高机体免疫功能，减轻机体炎症反应。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effects of ulinastatin combined with continuous blood purification (CBP) on inflammatory factors and T cell subsets in severe acute pancreatitis (SAP). Methods: 117 patients with SAP who were admitted to our hospital from May 2016 to September 2018 were selected, the paitients were randomly divided into control group (n=58) and stduy group (n=59) according to the digital table method. The control group was treated with ulinastatin on the basis of basic symptomatic treatment, and the study group was treated with CBP on the basis of the control group. The clinical efficacy, improvement of clinical indicators, inflammatory factors and changes of T cell subsets were compared between the two groups. Results: The total clinical effective rate of the study group after treatment was 66.10% (39/59), which was higher than 46.55% (27/58) of the control group (P<0.05). The hospital stay, the time of recovery of amylase and the time of remission of symptoms of the study group were shorter than those of the control group (P<0.05). The levels of serum interleukin-6(IL-6), interleukin-8(IL-8), tumor necrosis factor-α (TNF-α) in both groups after treatment were lower than those before treatment, and the study group were lower than those in the control group (P<0.05). The levels of CD4+, CD4+/CD8+ in both groups after treatment were higher than those before treatment, and the study group were higher than those in the control group (P<0.05), while the levels of CD8+ were lower than those before treatmen, and the study group was lower than that in the control group (P<0.05). Conclusion: Ulinastatin combined with CBP in the treatment of SAP patients has a definite curative effect, which can effectively improve the clinical symptoms of patients, improve the immune function of the body, and reduce the inflammatory reaction of organism. |
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