| 丁 博,李亚琴,李小燕,秦 凤,张碧玉,卢燕鸣.过敏原检测在幼儿喘息性疾病中的临床意义[J].现代生物医学进展英文版,2020,(2):268-272. |
| 过敏原检测在幼儿喘息性疾病中的临床意义 |
| Clinical Significance of Allergen Detection in the Asthmatic Diseases of Infants |
| Received:June 23, 2019 Revised:July 18, 2019 |
| DOI：10.13241/j.cnki.pmb.2020.02.013 |
| 中文关键词: 特应性评价 喘息 户尘螨 |
| 英文关键词: Atopic evaluation Wheezing Household dust mites |
| 基金项目:上海市科学技术委员会基金项目(18411951700) |
| Author Name | Affiliation | E-mail | | DING Bo | Department of Pediatrics, the Southern Division of Renji Hospital Affiliated to ShangHai JiaoTong University School of Medicine, Shanghai, 201112, China | dingbo1986515@sina.com | | LI Ya-qin | Department of Pediatrics, the Southern Division of Renji Hospital Affiliated to ShangHai JiaoTong University School of Medicine, Shanghai, 201112, China | | | LI Xiao-yan | Department of Pediatrics, the Southern Division of Renji Hospital Affiliated to ShangHai JiaoTong University School of Medicine, Shanghai, 201112, China | | | QIN Feng | Department of Pediatrics, the Southern Division of Renji Hospital Affiliated to ShangHai JiaoTong University School of Medicine, Shanghai, 201112, China | | | ZHANG Bi-yu | Department of Pediatrics, the Southern Division of Renji Hospital Affiliated to ShangHai JiaoTong University School of Medicine, Shanghai, 201112, China | | | LU Yan-ming | Department of Pediatrics, the Southern Division of Renji Hospital Affiliated to ShangHai JiaoTong University School of Medicine, Shanghai, 201112, China | |
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| 中文摘要: |
| 摘要 目的：探讨过敏原检测在幼儿喘息性疾病中的临床应用价值。方法：选择我院儿科收治的的1~5岁下呼吸道感染的特应性体质患儿217例，按照有无喘息症状分为喘息组与非喘息组。采集并比较两组患儿年龄、性别、过敏史(食物过敏，药物过敏，鼻炎，湿疹)、体外过敏原检测结果：TIgE（总IIgE）及sIgE（特异性IgE），（视sIgE≥2级为阳性)、一二级亲属过敏性疾病史。结果：(1)喘息组反复呼吸道感染及鼻炎人数均高于非喘息组(P＜0.05)。两组在湿疹、喜揉眼、食物过敏、药物过敏、一级亲属过敏史、二级亲属过敏史方面比较差异不具有统计学意义(P>0.05)。(2)两组体外过敏原检测结果比较：喘息组户尘螨阳性人数多于非喘息组；(3)喘息患儿组根据是否伴有鼻炎及湿疹分为：A组，喘息，不伴有鼻炎及湿疹；B组，喘息伴有鼻炎或者湿疹；C组，喘息，伴有鼻炎及湿疹。ABC三组TIgE、年龄、吸入过敏原个数、吸入过敏原阳性人数、户尘螨阳性率逐渐增多，差异具有统计学意义(P＜0.05)，其他吸入过敏原及食入过敏原比较差异无统计学意义。结论：反复呼吸道感染、鼻炎和喘息密切相关。尘螨是幼儿喘息、变应性鼻炎和特应性皮炎主要过敏原之一，是特应性体质患儿是否发生喘息的关键过敏原。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical application value of atopic evaluation in infant asthmatic diseases. Methods: 217 children with atopic constitution of lower respiratory tract infection aged 1-5 years who were admitted to the department of pediatrics of our hospital were selected. According to wheezing symptoms, the patients were divided into wheezing group and non-wheezing group. The age, gender, allergic history (food allergy, drug allergy, rhinitis, eczema), in vitro allergen test results (TIgE and sIgE, sIgE≥2 as positive), and the allergic disease history of the first and second degree relatives of the two groups were collected and compared. Results: (1)The number of recurrent respiratory infection and rhinitis in the wheezing group was higher than that in the non-wheezing group (P < 0.05). There was no statistically significant difference between the two groups in eczema, eye rubbing, food allergy, drug allergy, first-degree relative allergy history and second-degree relative allergy history (P>0.05). (2)Comparison of allergen test results between the two groups: the positive number of dust mite in the wheezing group was more than that in the non-wheezing group.(3)The wheezing children group was divided into A, B, C three groups according to the presence or absence of rhinitis and eczema. Group A, wheezing, not accompanied by rhinitis and eczema; Group B, wheezing with rhinitis or eczema; Group C, wheezing, with rhinitis and eczema. In the ABC groups, TIgE, age, number of inhaled allergens, number of positive inhaled allergens, and positive rate of dust mites gradually increased, and the difference was statistically significant (P < 0.05). There was no significant difference between other inhaled allergens and ingestion allergens. Conclusion: Repeated respiratory tract infection, rhinitis and wheezing are closely related. Dust mite is one of the main allergens of wheezing, allergic rhinitis and atopic dermatitis, and is the key allergen of wheezing in children with atopic constitution. |
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