| 岳 静,王丽娜,杨 蕊,杨 纨,周 旋,赖少阳,周罗绮,赵 捷.多囊卵巢综合征患者血清HSP70、IMA水平的变化及与性激素和氧化应激的相关性研究[J].现代生物医学进展英文版,2020,(1):63-67. |
| 多囊卵巢综合征患者血清HSP70、IMA水平的变化及与性激素和氧化应激的相关性研究 |
| Changes of Serum HSP70 and IMA Levels in Patients with Polycystic Ovary Syndrome and Their Correlation with Sex Hormones and Oxidative Stress |
| Received:May 23, 2019 Revised:June 18, 2019 |
| DOI：10.13241/j.cnki.pmb.2020.01.013 |
| 中文关键词: 多囊卵巢综合征 热休克蛋白70 缺血修饰白蛋白 性激素 氧化应激 |
| 英文关键词: Polycystic ovarian syndrome Heat shock protein 70 Ischemia modified albumin Sex hormones Oxidative stress |
| 基金项目:国家自然科学基金项目（81871311）；国家重点研发计划项目（2018YFC1002104） |
| Author Name | Affiliation | E-mail | | YUE Jing | Department of Gynaecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China | yuejing123h@sina.com | | WANG Li-na | Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology, Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China | | | YANG Rui | Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology, Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China | | | YANG Wan | Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology, Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China | | | ZHOU Xuan | Department of Gynaecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China | | | LAI Shao-yang | Department of Gynaecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China | | | ZHOU Luo-qi | Department of Gynaecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China | | | ZHAO Jie | Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology, Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China | |
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| 中文摘要: |
| 摘要 目的：探讨多囊卵巢综合征（PCOS）患者血清热休克蛋白70（HSP70）、缺血修饰白蛋白（IMA）水平的变化及与性激素指标和氧化应激指标的相关性。方法：选择2017年6月~2018年6月华中科技大学同济医学院附属同济医院收治的未经治疗的初诊PCOS患者87例为PCOS组，另随机选择同期在本院进行体检的健康育龄妇女87例为对照组，比较两组血清HSP70、IMA、性激素指标、氧化应激指标，分析血清HSP70、IMA水平与性激素、氧化应激的相关性。结果：PCOS组患者血清卵泡刺激素（FSH）、促黄体生成素（LH）、睾酮（T）、8-异前列腺素F2α（8-isoPGF2α）、丙二醛（MDA）、HSP70、IMA水平显著高于对照组，差异有统计学意义（P<0.05）；PCOS组患者血清超氧化物歧化酶（SOD）、谷胱甘肽过氧化酶（GSH-Px）水平低于对照组，差异有统计学意义（P<0.05）；PCOS组血清雌二醇（E2）、泌乳素（PRL）水平与对照组比较差异无统计学意义（P>0.05）。PCOS患者血清HSP70、IMA水平与血清FSH、LH、T、8-isoPGF2α、MDA水平呈正相关关系，与SOD、GSH-Px水平呈负相关关系（P<0.05），与E2、PRL水平无显著相关性（P>0.05）。结论：血清HSP70、IMA水平在PCOS患者呈现异常升高，其水平改变与性激素及氧化应激水平密切相关，提示HSP70、IMA可能参与了PCOS的病理过程，临床检测HSP70、IMA的水平变化有可能为PCOS诊疗提供有效的预测作用。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the changes of heat shock protein 70 (HSP70) and ischemic modified albumin (IMA) in patients with polycystic ovary syndrome (PCOS) and their correlation with sex hormones and oxidative stress. Methods: 87 patients with untreated initial diagnosed PCOS admitted to Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology from June 2017 to June 2018 were selected as PCOS group. A total of 87 healthy women who underwent physical examination at the same time were randomly selected as the control group. The serum levels of HSP70, IMA, sex hormones and oxidative stress indexes were compared between the two groups, the correlation between serum HSP70, IMA levels and sex hormones, oxidative stress indexes were analyzed. Results: The levels of serum follicular stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), 8-isoprostaglandin F2α (8-isoPGF2α), malondialdehyde (MDA), HSP70 and IMA in the PCOS group were significantly higher than those in the control group, the differences were statistically significant (P<0.05). The serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the PCOS group were lower than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in serum estradiol (E2) and prolactin (PRL) levels between the PCOS group and the control group (P>0.05). Serum HSP70 and IMA levels in PCOS patients were positively correlated with serum FSH, LH, T, 8-isoPGF2α and MDA levels, negatively correlated with SOD and GSH-Px levels (P<0.05), but there were no significant correlation with E2 and PRL levels (P>0.05). Conclusion: The levels of serum HSP70 and IMA in the PCOS patients are abnormally high, and the level changes of the serum are closely related to the sex hormones and oxidative stress. It is suggested that HSP70 and IMA may be involved in the pathological process of PCOS. Clinical detection of HSP70 and IMA may provide an effective predictive role for PCOS diagnosis and treatment. |
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