| 江 锋,高晓嵘,史 达,赵聪喆,付 婷.活血化瘀汤对髌骨骨折患者膝关节功能及炎症因子的影响[J].现代生物医学进展英文版,2019,19(24):4719-4722. |
| 活血化瘀汤对髌骨骨折患者膝关节功能及炎症因子的影响 |
| Curative Efficacy of Huoxue Huayu Decoction in Treatment of Patellar Fractures and Its Effects on Knee Function and Inflammatory Factors |
| Received:June 11, 2019 Revised:July 05, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.24.027 |
| 中文关键词: 髌骨骨折 活血化瘀汤 膝关节功能 炎症因子 |
| 英文关键词: Patellar fracture Huoxue huayu decoction Knee function Inflammatory cytokines |
| 基金项目:四川省自然科学基金项目（2014A0021） |
| Author Name | Affiliation | | JIANG Feng | Department of Orthopedics and Traumatology, Affiliated Hospital of Traditional Chinese Medicine, Southwest Medical University, Luzhou, Sichuan, 646000, China | | GAO Xiao-rong | Department of Neurology, Fourth ward, Yan'an University Affiliated Hospital, Yan'an, Shaanxi, 716000, China | | SHI Da | Orthopedics and Arthropathy Area of Traditional Chinese Medicine, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China | | ZHAO Cong-zhe | Orthopedics and Arthropathy Area of Traditional Chinese Medicine, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China | | FU Ting | Orthopedics and Arthropathy Area of Traditional Chinese Medicine, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China |
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| 中文摘要: |
| 摘要 目的：探讨髌骨骨折患者应用活血化瘀汤对患者膝关节功能、炎症因子的影响。方法：选择2015年3月到2017年3月西南医科大学附属中医医院接诊的髌骨骨折患者100例作为研究对象，以随机数表法分为观察组（n=53）和对照组（n=47），两组患者均采用切开复位克氏针张力带内固定，观察组加用活血化瘀汤。比较两组治疗后膝关节优良率、肿瘤坏死因子（TNF-α）、白细胞介素6（IL-6）、白细胞介素10（IL-10）、膝关节功能Lysholm评分、视觉模拟评分法（VAS）评分及不良反应发生情况。结果：治疗后，观察组患者优良率为92.45%，显著高于对照组的72.34%（P＜0.05）；治疗前，两组患者TNF-α、IL-6及IL-10水平无显著差异（P＞0.05）；治疗后，两组TNF-α、IL-6及IL-10水平较治疗前均显著改善（P＜0.05），且观察组TNF-α、IL-6均明显低于对照组，IL-10水平显著高于对照组（P＜0.05）；治疗前，两组患者Lysholm评分、VAS评分无显著差异（P＞0.05）；治疗后，两组Lysholm评分、VAS评分较治疗前均显著改善（P＜0.05），且观察组Lysholm评分均明显高于对照组，VAS评分显著低于对照组（P＜0.05）；观察组患者不良反应总发生率为1.89%，显著低于对照组的14.89%，差异具有统计学意义（P＜0.05）。结论：在髌骨骨折患者中使用活血化瘀汤效果显著，可有效改善患者膝关节功能、炎症因子水平，值得推广与运用。 |
| 英文摘要: |
| ABSTRACT Objective: To study Curative Efficacy of huoxue huayu decoctions in treatment of Patellar fractures and its effects on knee function and inflammatory factors. Methods: 100 cases of patella fracture patients admitted to Affiliated hospital of traditional Chinese medicine of southwest medical university from March 2015 to March 2017 were selected as the research objects, random number table method was used to divide the observation group (n=53) and control group (n=47). Patients in both groups were treated with open reduction kirschner wire tension band internal fixation, and the observation group was treated with huoxue huayu decoction. The excellent and good rates of knee joints, tumor necrosis factor (TNF-α), Interleukin 6 (IL-6), Interleukin 10 (IL-10), knee function Lysholm score, visual analogue score (VAS) score and adverse reactions were compared between the two groups after treatment. Results: After treatment, the excellent and good rates of the two groups were 92.45% and 72.34% respectively (P<0.05); Before treatment, there was no significant difference in the levels of TNF-α, IL-6 and IL-10 between the two groups (P>0.05); After treatment, the levels of TNF-α, IL-6 and IL-10 in the two groups were significantly improved compared with those before treatment (P<0.05), and the levels of TNF-α and IL-6 in the observation group were significantly lower than those in the control group, and the levels of IL-10 were significantly higher than those in the control group (P<0.05). Before treatment, there was no significant difference in Lysholm score and VAS score between the two groups (P>0.05); After treatment, Lysholm score and VAS score of the two groups were significantly improved compared with those before treatment (P<0.05), and Lysholm score of the observation group was significantly higher than that of the control group, VAS score was significantly lower than that of the control group (P<0.05); the total incidence of adverse reactions of the two groups were 1.89% and 14.89%, respectively, with statistical difference (P<0.05). Conclusion: The application of huoxue huayu decoction in patients with patella fracture has a significant effect and can effectively improve the level of knee joint function and inflammatory factors in patients, which is worthy of promotion and application. |
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