| 谌祎玮,周建波,谢 昀,李金徽,胡丽立.银杏达莫注射液联合地塞米松治疗突发性耳聋的疗效及对血清sVCAM-1、CGRP水平的影响[J].现代生物医学进展英文版,2019,19(23):4565-4568. |
| 银杏达莫注射液联合地塞米松治疗突发性耳聋的疗效及对血清sVCAM-1、CGRP水平的影响 |
| Curative Efficacy of Ginkgo Dexamethasone Injection Combined with Dexamethasone in the Treatment of Sudden Deafness in Children and Its Effects on the Serum Svcam-1 and CGRP Levels |
| Received:June 02, 2019 Revised:June 28, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.23.038 |
| 中文关键词: 银杏达莫 地塞米松 突发性耳聋 可溶性血管细胞间黏附因子-1 降钙素基因相关肽 |
| 英文关键词: Ginkgo biloba Dexamethasone Sudden deafness Soluble vascular intercellular adhesion factor-1 Calcitonin gene - related peptide |
| 基金项目:湖南省科技厅基金资助项目(707273922010) |
| Author Name | Affiliation | | SHEN Yi-wei | Department of Otorhinolaryngology Head and Neck Surgery, Hunan Provincial People's Hospital, Changsha, Hunan, 410006, China | | ZHOU Jian-bo | Department of Otorhinolaryngology Head and Neck Surgery, Hunan Provincial People's Hospital, Changsha, Hunan, 410006, China | | XIE Yun | Department of Otorhinolaryngology Head and Neck Surgery, Hunan Provincial People's Hospital, Changsha, Hunan, 410006, China | | LI Jin-hui | Department of Otorhinolaryngology Head and Neck Surgery, Hunan Provincial People's Hospital, Changsha, Hunan, 410006, China | | HU Li-li | School of Medicine, Hunan Normal University, Changsha, Hunan, 410006, China |
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| 中文摘要: |
| 摘要 目的：探讨银杏达莫注射液联合地塞米松治疗突发性耳聋的的疗效及对血清可溶性血管细胞间黏附因子-1(sVCAM-1)、降钙素基因相关肽(CGRP)水平的影响。方法：选择2017年10月到2019年3月于我院进行治疗的突发性耳聋患者70例作为研究对象，根据随机数表法将其分为观察组(n=36)和对照组(n=34)。对照组使用地塞米松治疗，观察组在对照组的基础上加用银杏达莫进行治疗。比较两组的临床疗效、治疗前后血清sVCAM-1、CGRP水平、平均听阀比、耳鸣残疾量表(THI)评分的变化及并发症的发生情况。结果：治疗后，观察组总有效率为94.44%，显著高于对照组(73.53%，P＜0.05)。两组患者治疗后血清sVCAM-1、CGRP水平、平均听阀比、THI评分均较治疗前显著改善，且观察组患者血清sVCAM-1水平、平均听阀比、THI评分均显著低于对照组，血清CGRP水平显著高于对照组(P<0.05)。治疗期间，观察组患者并发症总发生率为11.11%，显著低于对照组(32.35%，P<0.05)。结论：银杏达莫联合地塞米松治疗突发性耳聋的效果显著优于单用地塞米松治疗，这可能与其显著改善患者血清sVCAM-1、CGRP水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study Curative efficacy of Ginkgo dexamethasone injection combined with dexamethasone in treatment of Sudden deafness in childrenand its effectson serum Soluble vascular intercellular adhesion factor-1 (svcam-1), calcitonin gene-related peptide (CGRP). Methods: 70 cases of patients with sudden deafness who were treated in our hospital from October 2017 to March 2019 were selected as the study objects, and they were divided into observation group (n=36) and control group (n=34) according to the random number table method. The control group was treated with dexamethasone and the observation group was treated with ginkgo biloba on the basis of the control group. The clinical efficacy, serum svcam-1, CGRP level, average hearing valve ratio, tinnitus disability scale (THI) score changes and complications were compared between the two groups. Results: After treatment, the total effective rate of the observation group was 94.44%, significantly higher than that of the control group (73.53%, P<0.05). After treatment, the serum levels of svcam-1, CGRP, average listening valve ratio and THI score in the two groups were significantly improved compared with that before treatment, and the serum levels of svcam-1, average listening valve ratio and THI score in the observation group were significantly lower than those in the control group, while the serum CGRP level was significantly higher than that in the control group (P<0.05). During treatment, the total incidence of complications in the observation group was 11.11%, significantly lower than that in the control group (32.35%, P<0.05). Conclusion: The effect of dexamethasone combined with ginkgo biloba in the treatment of sudden deafness is significantly better than that of dexamethasone alone, which may be related to the significant improvement of serum svcam-1 and CGRP levels in patients. |
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