| 王薪景,郁小红,张 舜,罗仙忠,龚 燕.灵龟八法结合火针对失眠患者睡眠质量及炎性因子水平的影响[J].现代生物医学进展英文版,2019,19(23):4541-4544. |
| 灵龟八法结合火针对失眠患者睡眠质量及炎性因子水平的影响 |
| Effect of Linggui Bafa Combined with Fire Needling on Sleep Quality and Inflammatory Factor Levels in Insomnia Patients |
| Received:July 08, 2019 Revised:July 31, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.23.033 |
| 中文关键词: 灵龟八法 火针 失眠 睡眠质量 炎性因子 疗效 |
| 英文关键词: Linggui Bafa Fire Needling Insomnia Sleep quality Inflammatory factors Curative effect |
| 基金项目:浙江省中医药科技计划基金资助项目（2016ZB1179） |
| Author Name | Affiliation | E-mail | | WANG Xin-jing | Three District of Recuperation, Air Force Hangzhou Special Service Recuperation Center, Hangzhou, Zhejiang, 310002, China | L13001500678@163.com | | YU Xiao-hong | Three District of Recuperation, Air Force Hangzhou Special Service Recuperation Center, Hangzhou, Zhejiang, 310002, China | | | ZHANG Shun | Three District of Recuperation, Air Force Hangzhou Special Service Recuperation Center, Hangzhou, Zhejiang, 310002, China | | | LUO Xian-zhong | Department of Laboratory, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, 310006, China | | | GONG Yan | Department of Acupuncture, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, 310006, China | |
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| 中文摘要: |
| 摘要 目的：探讨灵龟八法结合火针对失眠患者睡眠质量及炎性因子水平的影响。方法：选取2017年5月~2019年3月期间空军杭州特勤疗养中心收治的失眠患者97例，根据数字表法将患者分为对照组（n=48，常规针刺治疗）和研究组（n=49，灵龟八法结合火针治疗），比较两组患者治疗4周后的临床疗效，比较两组治疗前、治疗4周后的中医症状积分、炎性因子水平，比较两组治疗前、治疗2周后、4周后的睡眠质量，记录两组治疗期间不良反应情况。结果：研究组治疗4周后的临床总有效率为93.88%（46/49），高于对照组的72.92%（35/48）（P<0.05）。两组治疗4周后难以入寐、多梦易醒、头晕、心悸的症状积分均下降，且研究组低于对照组（P<0.05）。两组治疗2周后、4周后匹兹堡睡眠质量指数（PSQI）评分均较治疗前降低（P<0.05），研究组治疗4周后PSQI评分较治疗2周后降低（P<0.05），研究组治疗4周后PSQI评分低于对照组（P<0.05）。两组治疗4周后血清白介素-1β（IL-1β）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均下降，且研究组低于对照组（P<0.05）。治疗期间对照组不良反应发生率为12.50%（6/48），研究组不良反应发生率为16.33%（8/49），两组不良反应发生率对比无统计学差异（P>0.05）。结论：灵龟八法结合火针治疗失眠患者，疗效显著，可改善患者临床症状，提高睡眠质量，并降低机体炎性因子水平，且安全性较好，具有一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of Linggui Bafa combined with Fire Needling on sleep quality and inflammatory factor levels in insomnia patients. Methods: 97 insomnia patients who were admitted to Air Force Hangzhou Special Service Recuperation Center from May 2017 to March 2019 were selected, and they were divided into control group (n=48, routine acupuncture treatment) and study group (n=49, Linggui Bafa combined with fire needle treatment) according to the digital table method. The clinical effects of the two groups at 4 weeks after treatment were compared. The scores of TCM symptoms and levels of inflammatory factors before and 4 weeks after treatment were compared. The sleep quality of the two groups before treatment, 2 weeks after treatment and 4 weeks after treatment were compared, and adverse reactions during treatment were recorded in both groups. Results: After 4 weeks of treatment, the total clinical effective rate of the study group was 93.88% (46/49), which was higher than 72.92% (35/48) of the control group (P<0.05). The symptom scores of insomnia, wakefulness, dizziness and palpitation decreased in both groups, and those in the study group were lower than those in the control group after 4 weeks of treatment(P<0.05). After 2 weeks and 4 weeks of treatment, Pittsburgh Sleep Quality Index (PSQI) scores in both groups were lower than those before treatment(P<0.05), PSQI scores after 4 weeks of treatment in the study group were lower than after 2 weeks of treatment(P<0.05), after 4 weeks of treatment, PSQI scores in the study group were lower than those in the control group(P<0.05). The levels of serum interleukin-1β(IL-1 β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the two groups decreased after 4 weeks of treatment, and the levels in the study group were lower than those in the control group(P<0.05). The incidence of adverse reactions was 12.50% (6/48) in the control group and 16.33% (8/49) in the study group. There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Linggui Bafa combined with fire needle therapy for insomnia patients has remarkable curative effect. It can improve the clinical symptoms of patients, improve the quality of sleep, and reduce the level of inflammatory factors. It is safe and has certain clinical application value. |
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