| 王 君,周 蕾,贺同强,肖 瑾,刘 丹.硝苯地平联合拉贝洛尔治疗妊娠期高血压的综合疗效及对血清UⅡ、PTM、Apelin水平影响[J].现代生物医学进展英文版,2019,19(21):4184-4187. |
| 硝苯地平联合拉贝洛尔治疗妊娠期高血压的综合疗效及对血清UⅡ、PTM、Apelin水平影响 |
| Curative Efficacy of Nifedipine Combined with Labetalol in the Treatment of Gestational Hypertension and Its Effects on the Serum U Ⅱ, PTM, Apelin Levels |
| Received:April 12, 2019 Revised:May 07, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.21.042 |
| 中文关键词: 硝苯地平 拉贝洛尔 妊娠期高血压 尾加压素Ⅱ 血浆血栓蛋白 Apelin |
| 英文关键词: Nifedipine Rabelor Hypertension during pregnancy The tail vasopressin Ⅱ Plasma thrombus protein Apelin |
| 基金项目:西安市卫生局科技攻关项目(J2013108) |
| Author Name | Affiliation | E-mail | | WANG Jun | Northwest Women and Children's Hospital, Xi'an, Shaanxi, 710061, China | quanl123@163.com | | ZHOU Lei | Northwest Women and Children's Hospital, Xi'an, Shaanxi, 710061, China | | | HE Tong-qiang | Northwest Women and Children's Hospital, Xi'an, Shaanxi, 710061, China | | | XIAO Jin | Northwest Women and Children's Hospital, Xi'an, Shaanxi, 710061, China | | | LIU Dan | The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China | |
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| 中文摘要: |
| 摘要 目的：研究硝苯地平联合拉贝洛尔治疗妊娠期高血压的综合疗效及对血清尾加压素Ⅱ(UⅡ)、血浆血栓蛋白(PTM)、Apelin水平的影响。方法：选取我院2015年8月到2016年8月收治的妊娠期高血压患者500例为研究对象，采用随机数字法将其分为对照组和观察组，每组各250例。对照组患者给予静脉滴注硫酸镁治疗，观察组患者在对照组基础上加用硝苯地平联合拉贝洛尔治疗。比较两组患者的治疗总有效率、母婴不良围生结局的发生情况以及治疗前后血清UⅡ、PTM、Apelin水平的变化。结果：治疗后，观察组的总有效率(91.60%)明显高于对照组(77.60%)(P=0.000)；观察组患者的血清UⅡ、PTM、Apelin水平明显低于对照组(P<0.01)，胎盘早剥、胎儿窘迫、新生儿窒息、终止妊娠、产后出血、低体重儿等不良围生结局发生率均明显低于对照组(P<0.05)。结论：硝苯地平、拉贝洛尔及硫酸镁三联治疗妊娠期高血压的临床疗效显著，能有效改善母婴围生结局，可能与其有效减低血清UⅡ、PTM、Apelin水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study Curative efficacy of Nifedipine combined with labetalol in treatment of Gestational hypertension and its effects on Tail vasopressin Ⅱ (U Ⅱ), blood clots in the blood plasma protein (PTM), Apelin impact. Methods: 500 patients with gestational hypertension admitted to our hospital from August 2015 to August 2016 were selected as research objects, they were divided into control group and observation group by random number method, with 250 cases in each group. Patients in the control group were treated with intravenous magnesium sulfate, and patients in the observation group were treated with nifedipine combined with rabelol on the basis of the control group. Compare two groups of the treatment of patients with total effective rate, and the occurrence of adverse perinatal outcomes and before and after treatment serum U Ⅱ, PTM, Apelin level changes. Results: After treatment, the total effective rate of the observation group (91.60%) was significantly higher than that of the control group (77.60%)(P=0.000). The observation group of patients with serum U Ⅱ, PTM, Apelin levels significantly lower than the control group (P<0.01), placental abruption, fetal distress and neonatal asphyxia, termination of pregnancy, postpartum hemorrhage and the incidence of adverse perinatal outcomes, such as low birth weight were significantly lower than the control group (P<0.05). Conclusion: Nifedipine, labetalol and magnesium sulfate sanlian clinical curative effect of treatment of gestational hypertension significantly, mother-to-child can effectively improve the perinatal outcome, to effectively reduce serum U Ⅱ, PTM, Apelin levels. |
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