| 寇晓桂,陈葆青,王 婷,霍晓颖,尹变玲,贾 娟.支气管肺泡灌洗术用于重症支气管哮喘的疗效评价及对肺功能、炎症因子水平的影响[J].现代生物医学进展英文版,2019,19(21):4180-4183. |
| 支气管肺泡灌洗术用于重症支气管哮喘的疗效评价及对肺功能、炎症因子水平的影响 |
| Efficay of Bronchoalveolar Lavage in the Treatment of Severe Bronchial Asthma and Its Influences on the Lung Function and Inflammatory Factors |
| Received:March 13, 2019 Revised:April 08, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.21.041 |
| 中文关键词: 重症支气管哮喘 支气管肺泡灌洗术 疗效 肺功能 炎症因子 |
| 英文关键词: Severe bronchial asthma Bronchoalveolar lavage Curative effect Lung function Inflammatory cytokines |
| 基金项目:陕西省重点研发计划项目(201805093YX1SF2(4)) |
| Author Name | Affiliation | E-mail | | KOU Xiao-gui | Department of Respiratory Medicine, Fourth Hospital of Xi'an, Xi'an, Shaanxi, 710004, China | kingzoomm@163.com | | CHEN Bao-qing | Department of Respiratory Medicine, Fourth Hospital of Xi'an, Xi'an, Shaanxi, 710004, China | | | WANG Ting | Department of Respiratory Medicine, Fourth Hospital of Xi'an, Xi'an, Shaanxi, 710004, China | | | HUO Xiao-ying | Department of Respiratory Medicine, Fourth Hospital of Xi'an, Xi'an, Shaanxi, 710004, China | | | YIN Bian-ling | Department of Respiratory Medicine, Fourth Hospital of Xi'an, Xi'an, Shaanxi, 710004, China | | | JIA Juan | Department of Respiratory Medicine, Affiliated Hospital of Medical Department of Xi'an Jiaotong University, Yulin, Shaanxi, 719000, China | |
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| 中文摘要: |
| 摘要 目的：探讨支气管肺泡灌洗术用于重症支气管哮喘的疗效及对肺功能、炎症因子水平的影响。方法：选择我院2015年3月~2018年3月收治的150例重症支气管哮喘患者，均接受支气管肺泡灌洗术治疗，分析其临床疗效，临床症状改善状况，治疗前后肺功能、炎症因子、血气指标的变化情况和不良反应的发生情况。结果：治疗后，150例患者中，临床控制70例，好转60例，无效20例，总有效率为86.67%(130/150)，哮鸣音消失时间为(5.17±0.64)d、ACT评分(27.85±3.86)分、住院时间为(5.73±0.75)d。治疗后，患者用力肺活量(FVC)、1s用力呼气容积(FEV1)、呼气峰流速(PEF)、血氧分压(PaO2)、血氧饱和度(SaO2)均显著高于治疗前(P<0.05)，嗜酸性粒细胞(EOS)、干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)及二氧化碳分压(PaCO2)低于治疗前(P<0.05)。150例患者中，发生支气管痉挛2例，咽喉部疼痛3例，无猝死、大咯血、气胸等严重并发症发生。结论：支气管肺泡灌洗术用于重症支气管哮喘的疗效肯定，可有效改善患者肺功能，并减轻炎症反应。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the curative efficacy of bronchoalveolar lavage in the treatment of severe bronchial asthma and its influences on the lung function and inflammatory factors. Methods: 150 patients with severe bronchial asthma who were given bronchoalveolar lavage in our hospital from March 2015 to March 2018 were selectd. The clinical efficacy, improvement of clinical symptoms, changes of pulmonary function, inflammatory factors and blood gas indexes before and after treatment, and the occurrence of safety adverse reactions were analyzed. Results: After treatment, among the 150 patients, 70 were clinically controlled, 60 were improved, and 20 were ineffective. The total effective rate was 86.67% (130/150), the disappearance time of wheezing sound was (5.17±0.64) d, ACT score (27.85±3.86), and hospitalization time was (5.73±0.75)d. After treatment, forced vital capacity (FVC), 1s forced expiratory volume (FEV1), PEF, PaO2, SaO2 were significantly higher than before treatment (P<0.05), eosinophil (EOS), Interferon-γ(IFN-γ), tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and carbon dioxide partial pressure(PaCO2) were significantly lower than before treatment (P<0.05). Of the 150 patients, 2 had bronchospasm and 3 had throat pain, and no severe complications such as sudden death, massive hemoptysis and pneumothorax was found. Conclusion: Bronchoalveolar lavage is effective for the severe bronchial asthma, it can effectively improve the lung function and reduce the inflammation in patients. |
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