| 童国玉,李翠柳,杨东辉,王维敏,沈山梅.糖尿病前期和新诊断2型糖尿病患者血清血管内皮生长因子B水平与胰岛素抵抗的相关性[J].现代生物医学进展英文版,2019,19(21):4049-4054. |
| 糖尿病前期和新诊断2型糖尿病患者血清血管内皮生长因子B水平与胰岛素抵抗的相关性 |
| Association between Serum Vascular Endothelial Growth Factor B and Insulin Resistance in Pre-diabetes and Newly Diagnosed Type 2 Diabetic Patients |
| Received:February 28, 2019 Revised:March 23, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.21.011 |
| 中文关键词: 2型糖尿病 血管内皮生长因子B 胰岛素抵抗 |
| 英文关键词: Type 2 diabetes Vascular endothelial growth factor B Insulin resistance |
| 基金项目:南京市医药卫生科研重点项目(ZKX16036)；中华医学会临床医学科研专项基金项目(13020210406) |
| Author Name | Affiliation | E-mail | | TONG Guo-yu | Department of Endocrinology, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China | tongguoyucn@aliyun.com | | LI Cui-liu | Department of Endocrinology, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China | | | YANG Dong-hui | Department of Endocrinology, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China | | | WANG Wei-min | Department of Endocrinology, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China | | | SHEN Shan-mei | Department of Endocrinology, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China | |
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| 中文摘要: |
| 摘要 目的：探讨在糖尿病前期和新诊断2型糖尿病(T2DM)患者血清血管内皮生长因子B(VEGF-B)与胰岛素抵抗(IR)的关系。方法：选取2011年7月至2013年12月在我院内分泌科门诊就诊的患者419例，其中160例糖耐量正常(NGT)、142例糖尿病前期、117例新诊断T2DM患者，采用ELISA法测定血清VEGF-B水平，进一步分析血清VEGF-B水平与胰岛功能、胰岛素敏感性、肥胖及糖脂代谢相关代谢指标间的相关性。结果：血清VEGF-B水平在NGT(130.8 pg/mL [IQR 61.3-227.5])、糖尿病前期(146.7 pg/mL [84.1-214.9])和T2DM(135.3 pg/mL [58.3-214.8])三组间无显著差异(P>0.05)。相关分析显示血清VEGF-B水平与体重指数(BMI)、腰臀比(WHR)、血脂谱、胰岛功能及胰岛素敏感性均无相关性(P>0.05)。结论：在糖尿病前期和新诊断T2DM患者，血清VEGF-B水平与肥胖、血脂谱、胰岛功能和胰岛素敏感性均无显著相关性，VEGF-B在人胰岛素抵抗及T2DM的发生中可能作用有限，仍需进一步研究明确其在代谢中的作用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the association between serum vascular endothelial growth factor (VEGF)-B and insulin resistance in pre-diabetes and newly diagnosed type 2 diabetes mellitus (T2DM) patients. Methods: Fasting serum VEGF-B levels were measured using ELISA in 160 normal glucose tolerance (NGT), 142 pre-diabetes, and 117 newly diagnosed T2DM subjects, and their association with insulin secretion, insulin sensitivity, parameters of adiposity, glucose and lipid metabolism was studied. Results: Fasting serum VEGF-B levels did not differ among NGT (130.8 pg/mL [IQR 61.3-227.5]), pre-diabetes (146.7 pg/mL [84.1-214.9]), and T2DM patients (135.3 pg/mL [58.3-214.8]) (all P>0.05). Correlated analysis showed that no significant association was found with body mass index (BMI), waist-to-hip ratio (WHR), lipid profiles, insulin secretion and sensitivity, as measured by a 75-g oral glucose tolerance test. Conclusion: Fasting serum VEGF-B levels are not related to adiposity, lipid profiles, insulin secretion and sensitivity in humans. These findings demonstrated that VEGF-B may be dispensable for insulin resistance and type 2 diabetes in humans. |
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