| 常子维,李秋红,朱华锋,冯苗娟,苏小丽,侯丽萍,高 山,于书春,田志强,赵亚萍,高广勋.一例少见青少年T幼淋巴细胞白血病的病例报道及文献回顾[J].现代生物医学进展英文版,2019,19(20):3849-3852. |
| 一例少见青少年T幼淋巴细胞白血病的病例报道及文献回顾 |
| Diagnosis and Treatment of a Rare Adolescent T-cell Prolymphocytic Leukemia and Literature Review |
| Received:February 28, 2019 Revised:March 23, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.20.011 |
| 中文关键词: 幼淋巴细胞白血病(T-PLL) 免疫表型 临床特点及实验室诊断 |
| 英文关键词: T-cell Prolymphocytic Leukemia (T-PLL) Immune phenotype Clinical characteristics and laboratory diagnosis |
| 基金项目:国家自然科学基金项目(30900639)；陕西省自然科学基金项目(2014JM2-8161)；吴阶平医学基金项目1项(320.6750.13276) |
| Author Name | Affiliation | E-mail | | CHANG Zi-wei | Department of hematology, XijingHospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | czw287763145@163.com | | LI Qiu-hong | Department of pediatrics, XijingHospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | ZHU Hua-feng | Department of hematology, XijingHospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | FENG Miao-juan | Department of hematology, XijingHospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | SU Xiao-li | Department of hematology, XijingHospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | HOU Li-ping | Department of hematology, XijingHospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | GAO Shan | Department of hematology, XijingHospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | YU Shu-chun | Department of hematology, XijingHospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | TIAN Zhi-qiang | Department of hematology, XijingHospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | ZHAO Ya-ping | Department of hematology, XijingHospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | | | GAO Guang-xun | Department of hematology, XijingHospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China | |
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| 中文摘要: |
| 摘要 目的：报道一例少见幼年幼淋巴细胞白血病(T-PLL)患者的病例资料及诊疗过程，并通过文献复习总结了T-PLL的临床特点和诊疗措施。方法：对病例资料进行对比分析，同时通过文献回顾研究T-PLL的特点及发生、发展及诊疗情况。结果：本病例为少见青少年型幼淋巴细胞白血病，细胞以成熟小淋巴细胞为主，特征免疫表型为CD7+CD5+CD4+CD8+CD3+，无染色体异常，有TCR基因重排。结论：T-PLL病例具有多态性及复杂性，在临床诊断中需要密切联系临床特点及实验室诊断，综合判断疾病情况，做出最优治疗方案。 |
| 英文摘要: |
| ABSTRACT Objective: To reporte a rare type of adolescent of T-cell Prolymphocytic Leukemia (T-PLL), and summarize the clinical features and diagnostic measures of T-PLL through reviewing the literatures. Methods: The clinical data of a rare type of adolescent of T-PLL was analyzed. The characteristics, occurrence, development and diagnosis and treatment of T-PLL were studied through literature review. Results: This case is a rare juvenile lymphoblastic leukemia. Most of the cells are mature small lymphocyte. The characteristic immunophenotype is CD7+CD5+CD4+CD8+CD3+. There is no chromosomal abnormality and TCR gene rearrangement positive. Conclusion: T-PLL has the characteristics of polymorphism and complexity. The clinical characteristics and laboratory diagnosis should be closely linked in clinical diagnosis, and disease conditions should be judged comprehensively to make the best treatment plan. |
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