| 张桂欣,彭丽君,陶可涛,冯 波,袁德玺,孙显飞.血清microRNA-335对根治术并碘131治疗的分化型甲状腺癌预后判断的临床价值分析[J].现代生物医学进展英文版,2019,19(17):3338-3341. |
| 血清microRNA-335对根治术并碘131治疗的分化型甲状腺癌预后判断的临床价值分析 |
| The Clinical Value of Serum MicroRNA-335 for the Prognostic prediction of the Differentiated Thyroid Cancer Patient after Total Thyroidectomy Combined with 131I Thyroid Remnant Ablation |
| Received:January 31, 2019 Revised:February 27, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.17.029 |
| 中文关键词: 分化型甲状腺癌 碘131清甲治疗 microRNA-335 预后 |
| 英文关键词: Differentiated thyroid cancer 131I thyroid remnant ablation MicroRNA-335 Prognosis |
| 基金项目:山东省自然科学基金项目(ZR2014HQ061) |
| Author Name | Affiliation | E-mail | | ZHANG Gui-xin | Surgery, Qingdao Fuwai Cardiovascular Hospital, Qingdao, Shandong, 266034, China | mengxianjiehb000@163.com | | PENG Li-jun | Ultrasound Department, Qingdao Fuwai Cardiovascular Hospital, Qingdao, Shandong, 266034, China | | | TAO Ke-tao | Surgery, Qingdao Fuwai Cardiovascular Hospital, Qingdao, Shandong, 266034, China | | | FENG Bo | Surgery, Qingdao Fuwai Cardiovascular Hospital, Qingdao, Shandong, 266034, China | | | YUAN De-xi | Surgery, Qingdao Fuwai Cardiovascular Hospital, Qingdao, Shandong, 266034, China | | | SUN Xian-fei | Department of Oncology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China | |
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| 中文摘要: |
| 摘要 目的：探讨血清microRNA-335对根治术并碘131清甲治疗的分化型甲状腺癌预后判断的临床价值。方法：采用实时荧光定量PCR技术检测100例经甲状腺癌根治术(甲状腺癌全切+肿瘤同侧中央组淋巴结清扫术)并碘131清甲治疗后的分化型甲状腺癌患者血清中microRNA-335的相对表达量，并用Pearson相关性分析法来分析其与患者术后复发时间的相关性。结果：100例分化型甲状腺癌患者经根治术并碘131清甲治疗后2周后血清microRNA-335水平较治疗前明显降低(P＜0.0001)。15例复发的患血清microRNA-335水平较未复发患者显著升高(P＜0.05)，且与其复发时间呈显著正相关(P＜0.0001)。结论：分化型甲状腺癌患者经甲状腺癌根治术并碘131清甲治疗后血清microRNA-335水平升高可能有助于预测其复发。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical value of serum microRNA-335 in predicting the prognosis of differentiated thyroid cancer treated with radical thyroidectomy and iodine 131 nail clearance. Methods: The relative expression level of serum microRNA-335 of 100 differentiated thyroid cancer patients were detected 2 weeks after accepting radical thyroidectomy (total thyroidectomy + ipsilateral central lymphadenectomy) combined with 131I thyroid remnant ablation by RT-qPCR. The correlation between the relative expression level of microRNA-335 and the Pearson correlation analysis was used to analyze the correlation between recurrence time and recurrence time. Results: The Serum microRNA-335 levels in 100 patients with differentiated thyroid cancer after radical thyroidectomy and iodine 131 nail clearance 2 weeks after treatment were significantly lower than those before treatment(P＜0.0001), Serum microRNA-335 levels in 15 relapsed patients were significantly higher than those in non-relapsed patients(P＜0.05), and There was a significant positive correlation between recurrence time and recurrence time(P＜0.0001). Conclusion: Increased serum microRNA-335 levels in patients with differentiated thyroid cancer after radical thyroidectomy and iodine 131 thyroidectomy may be helpful in predicting recurrence. |
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