| 李玲霞,李 佳,刘淑娟,邹 伟,贺艳丽,吕小慧,吕艳红,詹 瑛,赵淑华,吴利英,贺媛媛.宫颈癌患者外周血循环肿瘤细胞检测的意义[J].现代生物医学进展英文版,2019,19(17):3285-3288. |
| 宫颈癌患者外周血循环肿瘤细胞检测的意义 |
| Significance of Detection of Circulating Tumor Cells in the Cervical Cancer Patients |
| Received:March 28, 2019 Revised:April 26, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.17.017 |
| 中文关键词: CTC阳性率 CTC表达水平 子宫颈癌 临床病理 |
| 英文关键词: Positive expression rate of CTC Expression level of CTC Cervical cancer Pathologic and clinical feature |
| 基金项目:国家自然科学基金青年科学基金项目(81402133)；西京医院学科助推计划(XJZT18MJ90) |
| Author Name | Affiliation | E-mail | | LI Ling-xia | Department of Obstetrics and Gynecology, First Affiliated Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China | llxlemen@163.com | | LI Jia | Department of Obstetrics and Gynecology, First Affiliated Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China | | | LIU Shu-juan | Department of Obstetrics and Gynecology, First Affiliated Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China | | | ZOU Wei | Department of Obstetrics and Gynecology, First Affiliated Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China | | | HE Yan-li | Department of Obstetrics and Gynecology, First Affiliated Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China | | | LV Xiao-hui | Department of Obstetrics and Gynecology, First Affiliated Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China | | | LV Yan-hong | Department of Obstetrics and Gynecology, First Affiliated Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China | | | ZHAN Ying | Department of Obstetrics and Gynecology, First Affiliated Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China | | | ZHAO Shu-hua | Department of Obstetrics and Gynecology, First Affiliated Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China | | | WU Li-ying | Department of Obstetrics and Gynecology, First Affiliated Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China | | | HE Yuan-yuan | Department of Obstetrics and Gynecology, First Affiliated Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China | |
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| 中文摘要: |
| 摘要 目的：通过分析宫颈癌患者的临床资料与循环肿瘤细胞(CTC)之间的关系，评估其在宫颈癌患者诊疗过程中的临床意义。方法：回顾性分析我院2017年3月至2018年6月行机器人辅助下宫颈癌根治术的病例共82例，术前术后分别行CTC检测，分析CTC阳性率及CTC水平与临床参数的相关性。结果：不同病理类型、分化程度、脉管侵犯、淋巴转移及临床分期宫颈癌患者术前及术后CTC阳性率及CTC水平比较差异均无统计学意义(P＞0.05)。当宫颈癌浸润深度≥5 mm时，CTC的阳性率及CTC水平明显升高，CTC阳性率的差异仅在术前有统计学意义(P＜0.05)；而CTC水平的差异在术前及术后均有统计学意义(P＜0.05)。结论：CTC的阳性表达及水平与肿瘤的浸润深度密切相关。检测宫颈癌患者CTC水平可为宫颈癌的诊治及预后评估提供重要参考价值。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the correlation of circulating tumor cells (CTC) with the clinicopathological parameters and evaluate its clinical value for the diagnosis and treatment of cervical cancer patients. Methods: 82 cases of cervical cancer radical surgery underwent robotic assisted radical surgery from March 2017 to June 2018 in the xijing hospital were selected. CTC test was performed before and after surgery. The correlation of the positive rate of CTC with the clinical parameters were analyzed. Results: There was no significant difference in the preoperative and postoperative positive rates of CTC and CTC levels between cervical cancer patients with different pathological types, differentiation, vascular invasion, lymphatic metastasis, and clinical stage(P>0.05). When the depth of cervical cancer infiltration was ≥5 mm the positive rate of CTC and CTC level were higher, the CTC level than significantly higher than that before operation(P<0.05). Conclusion: The positive expression and level of CTC are closely related to the depth of tumor invasion. Detection of CTC levels can provide important references for the the diagnosis, treatment and prognostic evaluation of cervical cancer. |
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