| 赵 运,董 静,袁向茹,邢 雪,马淑慧.益气温阳活血利水法治疗心肾综合征的疗效及对患者心肾功能及血浆脑钠肽、肾素、血管紧张素、醛固酮水平的影响[J].现代生物医学进展英文版,2019,19(14):2755-2759. |
| 益气温阳活血利水法治疗心肾综合征的疗效及对患者心肾功能及血浆脑钠肽、肾素、血管紧张素、醛固酮水平的影响 |
| Effect of Yiqiwenyang - huoxuelishui Therapy on the Heart and Renal Function as Well as the Plasma BNP, PRA, AngⅡ, ALD Levels of Patients with Cardiorenal Syndrome |
| Received:January 11, 2019 Revised:January 31, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.14.033 |
| 中文关键词: 益气温阳活血利水 心肾综合征 心肾功能 血浆肾素系统 |
| 英文关键词: Yiqiwenyang - huoxuelishui therapy Cardiorenal syndrome Heart and renal function Renin - angiotensin system |
| 基金项目:陕西省科学技术研究发展计划项目(2013K17-01) |
| Author Name | Affiliation | E-mail | | ZHAO Yun | Department of internal medicine, the Second Affiliated Hospital of Shaanxi University of traditional Chinese medicine, Xianyang, Shaanxi, 712000, China | muxbux@163.com | | DONG Jing | Department of internal medicine, the Second Affiliated Hospital of Shaanxi University of traditional Chinese medicine, Xianyang, Shaanxi, 712000, China | | | YUAN Xiang-ru | Department of internal medicine, the Second Affiliated Hospital of Shaanxi University of traditional Chinese medicine, Xianyang, Shaanxi, 712000, China | | | XING Xue | Department of internal medicine, the Second Affiliated Hospital of Shaanxi University of traditional Chinese medicine, Xianyang, Shaanxi, 712000, China | | | MA Shu-hui | Department of internal medicine, the Second Affiliated Hospital of Shaanxi University of traditional Chinese medicine, Xianyang, Shaanxi, 712000, China | |
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| 中文摘要: |
| 摘要 目的：探讨益气温阳活血利水法治疗心肾综合征的临床疗效及对患者心肾功能及血浆脑钠肽(BNP)、肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)水平的影响。方法：研究对象为本院2017年3月~2018年9月收治的124例心肾综合征患者，采用随机数字表将其分成观察组与对照组，每组62例。两组患者均给予常规西医对症治疗，观察组同时给予中医益气温阳活血利水法治疗，两组均连续治疗3周后进行疗效评价。比较两组治疗前后心肾功能、血浆BNP、PRA、AngⅡ、ALD水平的变化情况。结果：治疗后，观察组总有效率为，显著高于对照组(P＜0.01)；两组左心射血分数(LVEF)、表皮生长因子受体(eGFR)均较治疗前明显上升，SCr、BUN、血浆CysC、BNP、PRA、AngⅡ、ALD水平均较治疗前明显降低(P＜0.01)，且观察组LVEF、eGFR明显高于对照组，SCr、BUN、血浆CysC、BNP、PRA、AngⅡ、ALD水平显著低于对照组(P＜0.01)；观察组LVESD、LVEDD与治疗前比较明显降低(P<0.01)，而对照组治疗前后LVESD、LVEDD无明显变化(P＞0.05)。结论：益气温阳活血利水法治疗心肾综合征的临床疗效显著优于单用常规西医对症治疗，其可有效改善患者的心肾功能，降低患者的血浆BNP、PRA、AngⅡ、ALD水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Yiqiwenyang-huoxuelishui therapy on the heart and renal function as well as the plasma brain natriuretic peptide (BNP), renin (PRA), angiotensinⅡ(AngⅡ), aldosterone (ALD) levels of patients with cardiorenal syndrome. Methods: The subjects of this study were selected from 124 cases of patients with cardiorenal syndrome admitted in our hospital from March 2017 to September 2018. They were divided into the observation group and the control group based on a random number table, 62 cases in each group. Both groups were treated with conventional western medicine, and the observation group was additionally given Yiqiwenyang - huoxuelishui therapy. The clinical efficacy was evaluated for both groups at 3 weeks after treatment. The heart and renal function, changes of plasma BNP, PRA, AngⅡ, ALD levels before and after treatment were compared between the two groups. Results: After treatment, the total effective rate of the observation group was 0, which was significantly higher than that of the control group (P<0.01). Two groups of left heart ejection fraction (LVEF), epidermal growth factor receptor (eGFR) was a significant increase in the, SCr, BUN, serum CysC, BNP, PRA, Ang Ⅱ, ALD levels were significantly lower than before treatment (P<0.01), and LVEF and eGFR observation group was obviously higher than that of control group, SCr, BUN, serum CysC, BNP, PRA, Ang Ⅱ, ALD were significantly lower than control group (P<0.01); LVESD and LVEDD in the observation group were significantly lower than before treatment (P<0.01), while LVESD and LVEDD in the control group were not significantly changed before and after treatment (P>0.05). Conclusion: Yi Yang qi and temperature, water treatment was more effective in the treatment of cardiorenal syndrome than the conventional western medicine alone, it can effectively improve the heart function, reduce the blood plasma BNP, PRA, Ang Ⅱ, ALD levels. |
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