| 李华峰,张广凤,赵文杰,李 敏,田霖林,单 洁,吴 迪.2型糖尿病内脏脂肪含量与胰岛β细胞功能及胰岛素抵抗的关系研究[J].现代生物医学进展英文版,2019,19(14):2740-2742. |
| 2型糖尿病内脏脂肪含量与胰岛β细胞功能及胰岛素抵抗的关系研究 |
| Effect of Visceral Fat Content on the Insulin Resistance and Islet β Cell Function in Type 2 Diabetes Mellitus |
| Received:February 10, 2019 Revised:February 28, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.14.029 |
| 中文关键词: 2型糖尿病 内脏脂肪 胰岛素抵抗 B细胞功能 |
| 英文关键词: Type 2 diabetes mellitus Visceral fat Insulin resistance B cell function |
| 基金项目:黑龙江省教育厅科学技术研究项目(2016-KYYWF-0876)；齐齐哈尔市科技局指令课题资助项目(SFGG-201428) |
| Author Name | Affiliation | E-mail | | LI Hua-feng | Endocrinology of the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, 161000, China | lihuafeng2005@163.com | | ZHANG Guang-feng | Endocrinology of the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, 161000, China | | | ZHAO Wen-jie | Endocrinology of the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, 161000, China | | | LI Min | Endocrinology of the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, 161000, China | | | TIAN Lin-lin | Endocrinology of the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, 161000, China | | | SHAN Jie | Endocrinology of the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, 161000, China | | | WU Di | Endocrinology of the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, 161000, China | |
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| 中文摘要: |
| 摘要 目的：研究2型糖尿病患者内脏脂肪含量与胰岛?茁细胞功能及胰岛素抵抗的关系。方法：对65例初诊2型糖尿病患者采用256 CT平脐经L4、5水平进行扫描并测量皮下及内脏脂肪含量，并以BMI不同进行分组，即体重正常组、超重组、肥胖组。采用稳态模式评估法(HOMA)计算胰岛素抵抗指数、胰岛B细胞分泌功能，测量入组患者的相关人体指标、空腹血生化检查指标。结果：超体重组、肥胖组患者腰围、体重指数（body mass index, BMI）、甘油三酯(triglyceride, TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol, LDL-C)、空腹血糖，(fasting blood-glucose, FBG)、空腹胰岛素（fasting insulin, FINS）INS、稳态模型胰岛素抵抗指数(Homeostatic Model Assessment for Insulin Resistance, HOMA-IR)、胰岛β细胞功能指数(Homeostasis model assessment- β, HOMA-β)指标肥胖组、超重组均明显高于正常体重组(P＜0.05)，超体重组、肥胖组内脏脂肪含量、内脏脂肪面积、皮下脂肪含量、脂肪总含量、脂肪百分比，超重组、肥胖组均明显高于正常体重组(P＜0.05)，且肥胖组各项指标明显高于超重组(P＜0.05)。多元回归分析显示腹部脂肪总含量、内脏脂肪含量、皮下脂肪含量、内脏脂肪面积、BMI与胰岛素抵抗呈正相关，而其中内脏脂肪含量及面积关系最密切。结论：内脏脂肪含量是2型糖尿病胰岛素抵抗及B细胞功能变化的独立影响因素。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between type 2 diabetes mellitus patients with visceral fat content and pancreatic beta cell function and insulin resistance. Methods: 65 newly diagnosed patients with type 2 diabetes mellitus were scanned by 256 CT at L4 and L5 levels, and their subcutaneous and visceral fat contents were measured. They were divided into normal weight group, overweight group and obese group according to BMI. HOMA was used to calculate insulin resistance index and islet B cell secretion function, and the related human indexes and fasting blood biochemical indexes were measured. Results: The waist circumference, body mass index(BMI), triglyceride, LDL-C, FBG, FINS, HOMA-IR, HOMA-beta index of obesity group and overweight group were significantly higher than those of normal weight group (P<0.05). The visceral fat content, visceral fat area, subcutaneous fat content, total fat content, fat percentage, overweight, overweight, obesity group were significantly higher than those of normal weight group (P<0.05). Obesity group was significantly higher than normal weight group (P<0.05), and the index of obesity group was significantly higher than that of overweight group (P<0.05). Multivariate regression analysis showed that abdominal fat content, visceral fat content, subcutaneous fat content, visceral fat area, BMI were positively correlated with insulin resistance, and visceral fat content and area were most closely related. Conclusion: Visceral fat content is an independent factor influencing insulin resistance and B cell function in type 2 diabetes mellitus. |
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