| 胡 娜,刘 焕,吴志林,黄玲玲,郭 靖.右美托咪定联合丙泊酚在无痛胃肠镜中的应用及对患者认知功能的影响[J].现代生物医学进展英文版,2019,19(14):2687-2690. |
| 右美托咪定联合丙泊酚在无痛胃肠镜中的应用及对患者认知功能的影响 |
| Application of Dexmedetomidine Combined with Propofol for the Painless Gastroenteroscopy and Its Effect on the Cognitive Function of Patients |
| Received:February 06, 2019 Revised:February 27, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.14.017 |
| 中文关键词: 右美托咪定 丙泊酚 无痛胃肠镜 认知功能 |
| 英文关键词: Dexmedetomidine Propofol Painless gastroenteroscopy Cognitive function |
| 基金项目:湖北省自然科学基金项目(20131056) |
| Author Name | Affiliation | E-mail | | HU Na | Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China | jinjunhuahua@sina.com | | LIU Huan | Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China | | | WU Zhi-lin | Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China | | | HUANG Ling-ling | Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China | | | GUO Jing | Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China | |
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| 中文摘要: |
| 摘要 目的：探讨盐酸右美托咪定联合丙泊酚在无痛胃肠镜中的应用效果及对患者认知功能的影响。方法：选择2015年8月到2018年8月我院接诊的行无痛胃肠镜患者的90例为研究对象，按照数字表随机分组法分为观察组(n=47)和对照组(n=43)。对照组使用丙泊酚进行麻醉，观察组采用右美托咪定联合丙泊酚进行麻醉。比较两组患者的麻醉效果、诱导时间、清醒时间、离室时间、术前、术后简易智能状态量表(MMSE)评分及不良反应的发生情况。结果：两组患者麻醉优良率分别为97.87%、76.74%，观察组显著高于对照组(P<0.05)；两组患者诱导时间比较无显著性差异；观察组患者清醒时间、离室时间均显著短于对照组(P<0.05)；术后30 min、3 h及6 h，观察组患者MMSE评分均高于对照组(P<0.05)；观察组患者不良反应总发生率为10.64%，显著低于对照组的30.23%(P<0.05)。结论：盐酸右美托咪定联合丙泊酚用于无痛胃肠镜的麻醉效果明显优于单用丙泊酚，并可有效改善患者认知功能。 |
| 英文摘要: |
| ABSTRACT Objective: To study Application of dexmedetomidine combined with propofol in painless gastroenteroscopy and its effect on cognitive function of patients. Methods: 90 cases of painless gastroenteroscopy patients admitted to our hospital from August 2015 to August 2018 were selected as research objects, the observation group (n=47) and control group (n=43) were randomly divided according to the number table. The control group was treated with propofol for anesthesia, and the observation group was treated with dexmedetomidine combined with propofol for anesthesia. The anesthetic effect, induction time, awake time, ventricular departure time, preoperative and postoperative MMSE score and adverse reactions were compared between the two groups. Results: The excellent and good rates of anesthesia in the two groups were 97.87% and 76.74%, respectively. The observation group was significantly higher than the control group(P<0.05). There was no significant difference in induction time between the two groups. Patients in the observation group had significantly shorter awake time and time away from the room than those in the control group(P<0.05). At 30min, 3h and 6h after surgery, MMSE scores of patients in the observation group were all higher than those in the control group (P<0.05). The overall incidence of adverse reactions in the observation group was 10.64%, significantly lower than 30.23% in the control group (P<0.05). Conclusion: Dexmedetomidine hydrochloride combined with propofol for painless gastroenteroscopy is significantly better than propofol alone, and can effectively improve the cognitive function of patients. |
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