| 刘殊艳,刘文田,赵玉梅,刘志国,余国勇.痰热清注射液联合奈诺沙星对老年社区获得性肺炎患者血清炎症因子和免疫功能的影响[J].现代生物医学进展英文版,2019,19(13):2515-2518. |
| 痰热清注射液联合奈诺沙星对老年社区获得性肺炎患者血清炎症因子和免疫功能的影响 |
| Effect of Tanreqing Injection Combined with Nanofloxacin on the Serum Inflammatory Factors and Immune Function in the Elderly Patients with Community Acquired Pneumonia |
| Received:November 26, 2018 Revised:December 22, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.13.026 |
| 中文关键词: 痰热清注射液 奈诺沙星 老年社区获得性肺炎 血清炎症因子 免疫功能 |
| 英文关键词: Tanreqing injection Naloxacin Elderly community acquired pneumonia Serum inflammatory factor Immune function |
| 基金项目:内蒙古自治区自然科学基金项目(2016MS(LH)0827) |
| Author Name | Affiliation | E-mail | | LIU Shu-yan | General Department, The Third Affiliated Hospital of Inner Mongolia Medical University, Baotou, Inner Mongolia, 014010, China | Liushuyan196809@163.com | | LIU Wen-tian | Respiratory Medicine Department, Hanzhong Central Hospital of Shaanxi Province, Hanzhong, Shaanxi, 723000, China | | | ZHAO Yu-mei | General Department, The Third Affiliated Hospital of Inner Mongolia Medical University, Baotou, Inner Mongolia, 014010, China | | | LIU Zhi-guo | Osteoarticular Trauma Surgery Department, Hanzhong Central Hospital of Shaanxi Province, Hanzhong, Shaanxi, 723000, China | | | YU Guo-yong | Osteoarticular Trauma Surgery Department, Hanzhong Central Hospital of Shaanxi Province, Hanzhong, Shaanxi, 723000, China | |
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| 中文摘要: |
| 摘要 目的：探究痰热清注射液联合奈诺沙星对老年社区获得性肺炎患者血清炎症因子和免疫功能的影响。方法：选择2015年12月-2017年12月我院诊治的老年社区获得性肺炎患者218例，按照其入院顺序经随机数字表法分为两组，每组各109例。其中，对照组给予奈诺沙星进行治疗，研究组在对照组基础上联合痰热清注射液进行治疗，对比两组患者的治疗总有效率、临床症状改善时间、治疗前后血清肿瘤坏死因子(TNF-α)、超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、总淋巴细胞(TT)、Th细胞(CD4)及自然杀伤细胞(NK)水平的变化。结果：治疗后，研究组患者的治疗总有效率[90.8%(99/109)]显著高于对照组[74.3%(81/109)](P＜0.05)；研究组患者退热、咳嗽缓解、咳痰缓解、肺部阴影吸收＞50等时间均明显短于对照组(P＜0.05)；两组患者血清TNF-α、hs-CRP、IL-6水平均显著低于治疗前，且研究组以上指标均显著低于对照组(P＜0.05)；两组患者TB、TT、CD4及NK水平均比治疗前显著升高，且研究组以上指标均明显高于对照组(P＜0.05)。结论：痰热清注射液联合奈诺沙星治疗老年社区获得性肺炎的效果显著优于单用予奈诺沙星治疗，其可有效改善患者的临床症状、降低血清炎症因子水平和提高免疫功能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Tanreqing injection combined with aloxacin on the serum inflammatory factors and immune function of elderly patients with community-acquired pneumonia. Methods: A total of 218 cases of elderly patients with community-acquired pneumonia who were treated in our hospital from December 2015 to December 2017 were enrolled. According to the admission order, they were divided into two groups according to the random number table method, with 109 cases in each group. The control group was treated with naloxartan, and the study group was treated with Tanreqing injection on the basis of control group. The total effective rate, the time of improvement of clinical symptoms, the changes of serum tumor necrosis factor(TNF-α), high-sensitivity C-reactive protein(hs-CRP), interleukin-6(IL-6), total lymphocytes(TT), The cells(CD4) and natural killer(NK) cells before and after treatment were compared between the two groups. Results: After treatment, the total effective rate of study group [90.8% (99/109)] was significantly higher than that of the control group [74.3% (81/109)] (P<0.05). The time of fever, cough relief, and lung shadow absorption >50 were shorter than those of the control group (P<0.05). The levels of serum TNF-α, hs-CRP and IL-6 of both groups were significantly lower than those before treatment, and the above indexes of study group were significantly lower than those of the control group (P<0.05). The levels of TB, TT, CD4 and NK in both groups were significantly higher than those before treatment, and the above indexes in the study group were significantly higher than those in the control group (P<0.05). Conclusion: Tanreqing injection combined with naloxartan is more effective than that of naloxartan alone in the treatment of elderly patients with community-acquired pneumonia, it can effectively improve the clinical symptoms, reduce the serum inflammatory factor levels and improve the immune function. |
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