| 何 超,曾玲玲,张心浩,蔡兰军.OSAHS风险对患者静脉麻醉术后认知功能障碍的影响[J].现代生物医学进展英文版,2019,19(12):2278-2282. |
| OSAHS风险对患者静脉麻醉术后认知功能障碍的影响 |
| Impact of the Risk of OSAHS on the Postoperative Cognitive Dysfunction after Intravenous Anesthesia |
| Received:December 08, 2018 Revised:December 30, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.12.016 |
| 中文关键词: 术后认知功能障碍 睡眠呼吸暂停低通气综合征，阻塞性 间歇性低氧血症 NoSAS评分 MoCA评分 |
| 英文关键词: Postoperative cognitive dysfunction Sleep apnea hyponea syndrome Obstructive Intermittent hypoxia NoSAS test MoCA test |
| 基金项目:国家自然科学基金青年科学基金项目(81401322) |
| Author Name | Affiliation | E-mail | | HE Chao | Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China | hechaoent@163.com | | ZENG Ling-ling | Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China | | | ZHANG Xin-hao | Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China | | | CAI Lan-jun | Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China | |
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| 中文摘要: |
| 摘要 目的：探讨OSAHS风险与静脉麻醉手术患者术后发生认知功能障碍的关系。方法：采用NoSAS评分对55例静脉麻醉手术患者进行OSAHS风险评估，并将其分为对照组23例(NoSAS < 8分)和OSAHS组32例(NoSAS ≥8分)，以蒙特利尔认知评估量表(MoCA)对两组患者在术前和术后第一天进行认知功能评估，计算每位患者手术前后MoCA评分的差值△MoCA(术前MoCA-术后MoCA)，比较两组患者手术前后的MoCA评分及△MoCA。结果：OSAHS组术前MoCA评分(25.83±1.80)明显低于对照组术前MoCA评分(28.05±1.31)(P<0.05)。OSAHS组术后MoCA评分(25.13±1.64)较术前无明显变化(P>0.05)，对照组术后MoCA评分(26.73±1.17)明显低于术前(P<0.05)。OSAHS组△MoCA(0.39±1.03)明显低于对照组(1.32±1.08)，主要表现为视空间与执行功能[(0.09±0.29) vs. (0.30±0.32)]、注意力[(0.09±0.60) vs. (0.47±0.70)]和延时回忆力[(0.17±0.39) vs. (0.47±0.51)]两方面(P<0.05)。结论：OSAHS高风险患者静脉麻醉术后认知功能障碍的程度较OSAHS低风险人群显著降低。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the risk of OSAHS and postoperative cognitive dysfunction of patients after intravenous anesthesia. Methods: Fifty five patients undergoing surgery after intravenous anesthesia were screened for the risk of OSAHS using the NoSAS test, and divided into control group(n=23, NoSAS<8) and OSAHS group(n=32, NoSAS≥8). The cognitive function was assessed using Montreal cognitive assessment(MoCA) the day before surgery and one day after surgery. The change of cognitive functions were evaluated, expressed as the difference between pre- and postoperative MoCA values(△MoCA=preoperative MoCA-postpreoperative MoCA). MoCA between pre- and postoperation in each group, △MoCA between the two groups were compared. Results: Preoperatively, OSAHS patients showed a significant worse performance for MoCA values(25.83±1.80) than those in control group(28.05±1.31)(P<0.05). However, when comparing pre- and postoperative cognitive function in each group, the OSAHS patients did not show a significant loss for postoperative MoCA values(25.13±1.64) compared with preoperative MoCA(P>0.05), whereas the control group showed a significant worse performance for postoperative MoCA values(26.73±1.17) than prepostoperative MoCA(P<0.05). We found △MoCA in OSAHS group(0.39±1.03) were significantly decreased compared with △MoCA in control group(1.32±1.08), mainly respect to visuospatial/executive[(0.09±0.29) vs. (0.30±0.32)], attention[(0.09±0.60) vs. (0.47±0.70)] and delayed memory[(0.17±0.39) vs. (0.47±0.51)](P<0.05). Conclusion: Patients with a high risk of OSAHS screened by NoSAS test showed a significant lower level on postoperative cognitive dysfunction. |
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