| 王帅道,孙充洲,代 强,吴礼孟,赵婷慧,周 虹.负压封闭引流技术联合前列地尔注射液对重度烧伤患者的疗效观察[J].现代生物医学进展英文版,2019,19(10):1941-1944. |
| 负压封闭引流技术联合前列地尔注射液对重度烧伤患者的疗效观察 |
| Clinical Observation of Negative Pressure Closed Drainage Combined with Alprostadil Injection in the Treatment of Severe Burns |
| Received:January 18, 2019 Revised:February 10, 2019 |
| DOI：10.13241/j.cnki.pmb.2019.10.029 |
| 中文关键词: 负压封闭引流技术 前列地尔注射液 重度烧伤 创面愈合 炎性反应 |
| 英文关键词: Vacuum sealing drainage Alprostadil injection Severe burn Wound healing Inflammatory response |
| 基金项目:四川省卫生和计划生育委员会科研项目（150085） |
| Author Name | Affiliation | | WANG Shuai-dao | Mianyang Central Hospital, Mianyang, Sichuan, 621000, China | | SUN Chong-zhou | Mianyang Central Hospital, Mianyang, Sichuan, 621000, China | | DAI Qiang | Mianyang Central Hospital, Mianyang, Sichuan, 621000, China | | WU Li-meng | Mianyang Central Hospital, Mianyang, Sichuan, 621000, China | | ZHAO Ting-hui | Mianyang Central Hospital, Mianyang, Sichuan, 621000, China | | ZHOU Hong | Mianyang Central Hospital, Mianyang, Sichuan, 621000, China |
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| 中文摘要: |
| 摘要 目的：研究负压封闭引流技术联合前列地尔注射液对重度烧伤患者的疗效观察。方法：选取2017年2月至2018年2月的67例患者。按照随机数表法分为观察组（n=36）和对照组（n=31），对照组采用负压封闭引流技术治疗，观察组采用负压封闭引流技术联合前列地尔注射液治疗。观察两组治疗疗效情况，临床治疗指标（创面愈合时间、创面愈合率、VAS评分、住院时间），C反应蛋白（CRP）、降钙素原（PCT）水平，不良反应发生率。结果：治疗后，观察组总有效率显著高于对照组[86.11%（31/36）vs 61.29%（19/31）]（P＜0.05）； 创面愈合时间、创面愈合率、VAS评分、住院时间均显著低于对照组[（16.93±4.19）天vs（24.27±6.01）天,（92.72±5.03）% vs（81.34±2.48）%，（2.93±0.52）分vs（6.70±1.30）分，（24.09±7.43）天vs（46.98±10.72）天]（P＜0.05）；CRP、PCT水平均显著低于对照组[（27.93±3.81）mg/L vs（83.86±7.43）mg/L，（0.10±0.02）ng/L vs（0.43±0.06）ng/L]（P＜0.05）；不良反应总发生率显著低于对照组[8.33%（3/36）vs 38.70%（12/31）]（P＜0.05）。结论：负压封闭引流技术联合前列地尔注射液对重度烧伤患者的疗效显著，可促进创面恢复，避免感染，并发症少，安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: To study Clinical Observation of Negative Pressure Closed Drainage Combined with Alprostadil Injection in the Treatment of Severe Burns. Methods: 67 who received therapy from February 2017 to February 2018 in our hospital were selected as research objects. According to random number table, those patients were divided into the observation group (n=36) and the control group (n=31). The control group was treated with vacuum sealing drainage, while the observation group treated with Negative Pressure Closed Drainage Combined with Alprostadil Injection. Then the Therapeutic efficacy, clinical treatment indicators (wound healing time, wound healing rate, VAS score, hospitalization time), C-reactive protein (CRP) and procalcitonin (PCT) levels, adverse reaction rate of two groups after treatment were compared. Results: After treatment, The total effective rate of observation group was significantly higher than that of control group（P＜0.05）. The wound healing time, wound healing rate, VAS score and hospitalization time were significantly lower than those of the control group[（16.93±4.19）d vs（24.27±6.01）d,（92.72±5.03）% vs（81.34±2.48）%,（2.93±0.52）scores（6.70±1.30）scores,（24.09±7.43）d vs（46.98±10.72）d]（P＜0.05）. The levels of CRP and PCT were significantly lower than those of the control group[（27.93±3.81）mg/L（83.86±7.43）mg/L（0.10±0.02）ng/L（0.43±0.06）ng/L]（P＜0.05）. The total incidence of adverse reactions was significantly lower than that in the control group [8.33%（3/36）vs 38.70%（12/31）]（P＜0.05）. Conclusion: Vacuum sealing drainage combined with alprostadil injection has a significant effect on severe burn patients. It can promote wound recovery, avoid infection, fewer complications, and is safe and reliable. |
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