| 刘家欣,王 丹,刘 森,万进东,王沛坚.α-细辛醚和β-细辛醚在心脑血管病中的作用及机制研究进展[J].现代生物医学进展英文版,2019,19(9):1797-1800. |
| α-细辛醚和β-细辛醚在心脑血管病中的作用及机制研究进展 |
| Research Progress of the Effects and Mechanisms of alpha-Asarone and beta-Asarone in Cardio-cerebrovascular Diseases |
| Received:June 06, 2018 Revised:June 30, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.09.044 |
| 中文关键词: α-细辛醚 β-细辛醚 心脑血管疾病 |
| 英文关键词: α-asarone β-asarone Cardio-cerebrovascular disease |
| 基金项目:国家自然科学基金项目（81400289）；四川省杰出青年学术技术带头资助计划（2016JQ0032）；四川省教育厅科研创新团队项目（18TD0030）四川省医学会科研项目（S15022）；成都医学院科研创新团队项目（CYTD16-01） |
| Author Name | Affiliation | E-mail | | LIU Jia-xin | 1 Department of Cardiology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China
2 Key Laboratory of Aging and Vascular Homeostasis, Sichuan Provincial Universities, Chengdu, Sichuan, 610500, China | 963163589@qq.com | | WANG Dan | 1 Department of Cardiology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China
2 Key Laboratory of Aging and Vascular Homeostasis, Sichuan Provincial Universities, Chengdu, Sichuan, 610500, China | | | LIU Sen | 1 Department of Cardiology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China
2 Key Laboratory of Aging and Vascular Homeostasis, Sichuan Provincial Universities, Chengdu, Sichuan, 610500, China | | | WAN Jin-dong | 1 Department of Cardiology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China
2 Key Laboratory of Aging and Vascular Homeostasis, Sichuan Provincial Universities, Chengdu, Sichuan, 610500, China | | | WANG Pei-jian | 1 Department of Cardiology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China
2 Key Laboratory of Aging and Vascular Homeostasis, Sichuan Provincial Universities, Chengdu, Sichuan, 610500, China | |
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| 中文摘要: |
| 摘要：α-细辛醚和β-细辛醚是天南星科多年生草本植物石菖蒲的主要活性成分。近年研究发现，α-细辛醚和β-细辛醚除具有抗肿瘤、杀虫抑菌、止咳平喘、保护神经元、抗癫痫、抗抑郁等作用外，其在心脑血管疾病方面具有较好的药理活性。本文通过查阅近年国内外相关文献，从α-细辛醚和β-细辛醚保护心肌和血管细胞（包括血管内皮细胞和血管平滑肌细胞），抗血栓形成，降血脂，改善血管功能等方面进行综述，为进一步深入挖掘上述成分在心脑血管疾病中的作用，探索相关的机制提供参考。 |
| 英文摘要: |
| ABSTRACT: Alpha-asarone and β-asarone are the main active ingredients of the herbaceous perennial plant of Araceae. In recent years, it has been found that α-asarone and β-asarone possess good effects in preventing cardio-cerebrovascular diseases besides an- ti-cancer, insecticide and bacteriostasis, antitussive and antiasthmatic, neuroprotection, anti-epileptic anti-depression and other effects. This article summarizes the relevant literatures both at home and abroad in recent years, provides an overview of their cardio-cerebrovas- cular related activities from their protective effects on cardiomyocytes, vascular cells(endothelial cell and vascular smooth muscle cell), antithrombotic, hypolipidemic, vascular tension and so on. This review provides references to further explore the roles and mechanisms of the above components in cardio-cerebrovascular diseases. |
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