| 魏 鹏,罗传皊,宋 堃,王 月,陈方周.异甘草酸镁对急性重症胰腺炎患者血清CAM-1、SIL-2R、IL-2水平及肝肾功能的影响[J].现代生物医学进展英文版,2019,19(9):1766-1769. |
| 异甘草酸镁对急性重症胰腺炎患者血清CAM-1、SIL-2R、IL-2水平及肝肾功能的影响 |
| Effect of Magnesium Isoglycyrrhizinate on the Serum Levels of CAM-1, SIL-2 R and IL-2, Liver and Kidney Function of Patients with Severe Acute Pancreatitis |
| Received:August 23, 2018 Revised:September 18, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.09.036 |
| 中文关键词: 急性重症胰腺炎 异甘草酸镁 胞问粘附分子-1 可溶性白细胞介素-2受体 白细胞介素-2 |
| 英文关键词: Acute severe pancreatitis Magnesium isoglycyrrhizinate Cell adhesion molecule-1 Soluble interleukin-2 receptor Interleukin-2 |
| 基金项目:山东省医药卫生科技发展计划项目(2015WS0502) |
| Author Name | Affiliation | E-mail | | WEI Peng | Department of critical care medicine, Central Hospital of Zaozhuang Mining Group, Zaozhuang, Shandong, 277000, China | liuwenshuai269@163.com | | LUO Chuan-ling | Department of critical care medicine, Central Hospital of Zaozhuang Mining Group, Zaozhuang, Shandong, 277000, China | | | SONG Kun | Department of critical care medicine, Zaozhuang hospital, Beijing University of Chinese Medicine, Zaozhuang, Shandong, 277000, China | | | WANG Yue | Department of critical care medicine, Central Hospital of Zaozhuang Mining Group, Zaozhuang, Shandong, 277000, China | | | CHEN Fang-zhou | Department of critical care medicine, Affiliated Hospital of Tai'an Medical College, Tai'an, Shandong, 271000, China | |
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| 中文摘要: |
| 摘要 目的：探讨异甘草酸镁对急性重症胰腺炎患者血清胞间粘附分子-1(CAM-1)、可溶性白细胞介素-2受体(SIL-2R)、白细胞介素-2(IL-2)水平及肝肾功能的影响。方法：选择2014年3月~2016年9月于我院接受治疗的86例急性重症胰腺炎患者，按随机数字表法分为对照组与实验组，每组43例。对照组选用常规治疗，实验组在常规治疗基础上加以异甘草酸镁治疗，两组均持续治疗14天。比较两组的临床疗效，治疗前后血清CAM-1、SIL-2R、IL-2、谷草转氨酶、谷丙转氨酶、尿素氮、血肌酐水平的变化及不良反应的发生情况。结果：治疗后，实验组总有效率为90.69%，显著高于对照组(P<0.05)；两组血清CAM-1、SIL-2R、IL-2、谷草转氨酶、谷丙转氨酶、尿素氮、血肌酐水平均较治疗前显著降低，且实验组以上指标均明显低于对照组(P<0.05)。两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论：与常规治疗相比，异甘草酸镁可显著提高急性重症胰腺炎的临床效果，降低血清CAM-1、SIL-2R、IL-2水平，保护肝肾功能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of magnesium isoglycyrrhizinate on the serum levels of Cell adhesion molecule-1(CAM-1), soluble interleukin-2 receptor (SIL-2 R), interleukin-2 (IL-2) levels, liver and kidney function of patients with severe acute pancreatitis. Methods: 86 cases of patients with acute severe pancreatitis from March 2014 to September 2016 in our hospital were divided into the control group and the experimental group according to random number table method, with 43 cases in each group. The control group was given conventional treatment, while the experimental group was given magnesium isoglycyrrhizate based on the control group, both groups were treated for 14 days. The curative effect, changes of serum levels of CAM-1, SIL-2 R and IL-2, aspertate aminotrans- ferase, cereal third transaminase, urea nitrogen, serum creatinine before and after the treatment and the incidence of adverse reactions were compared between two groups. Results: After treatment, the total effective rate of experimental group was 90.69%, which was higher than that of the control group(P<0.05); the serum levels of CAM-1,SIL-2 R and IL-2, aspertate aminotransferase, cereal third transami- nase, urea nitrogen, serum creatinine of two group were significantly reduced than those before treatment, which were all significantly lower in the experimental group than those of the control group(P<0.05). there was no difference in the occurrence of adverse reactions between the two groups(P>0.05). Conclusion: Magnesium isoglycyrrhizate was more effective for severe acute pancreatitis than conven- tional treatment alone, which could decrease the serum levels of CAM-1, SIL-2 R and IL-2 and protect the liver and kidney function. |
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