| 叶宝飞,胡万钧,张泰标,甘发荣,吴多艺.独活寄生汤加减治疗对风寒湿痹型腰椎间盘突出症患者生活质量、自由基代谢及睡眠质量的影响[J].现代生物医学进展英文版,2019,19(9):1739-1742. |
| 独活寄生汤加减治疗对风寒湿痹型腰椎间盘突出症患者生活质量、自由基代谢及睡眠质量的影响 |
| Effect of Modified Duhuo Jisheng Decoction on Quality of Life, Free Radical Metabolism and Sleep Quality of Patients with Wind-cold-dampness Syndrome of Lumbar Intervertebral Disc Herniation |
| Received:November 30, 2018 Revised:December 23, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.09.030 |
| 中文关键词: 独活寄生汤 风寒湿痹型 腰椎间盘突出症 生活质量 自由基代谢 睡眠质量 |
| 英文关键词: Duhuo Jisheng decoction Wind-cold-dampness syndrome Lumbar intervertebral disc herniation Quality of life Free radical metabolism Sleep quality |
| 基金项目:海南省卫生和计划生育委员会科研项目（15A120418） |
| Author Name | Affiliation | E-mail | | YE Bao-fei | First Department of Orthopedics, Chinese Medicine Hospital of Hainan Province, Haikou, Hainan, 570203, China | yfrfxd@163.com | | HU Wan-jun | First Department of Orthopedics, Chinese Medicine Hospital of Hainan Province, Haikou, Hainan, 570203, China | | | ZHANG Tai-biao | First Department of Orthopedics, Chinese Medicine Hospital of Hainan Province, Haikou, Hainan, 570203, China | | | GAN Fa-rong | First Department of Orthopedics, Chinese Medicine Hospital of Hainan Province, Haikou, Hainan, 570203, China | | | WU Duo-yi | First Department of Orthopedics, Chinese Medicine Hospital of Hainan Province, Haikou, Hainan, 570203, China | |
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| 中文摘要: |
| 摘要 目的：探讨独活寄生汤加减治疗对风寒湿痹型腰椎间盘突出症（LIDP）患者生活质量、自由基代谢及睡眠质量的影响。方法：选取2012年1月~2017年12月期间海南省中医院骨一科收治的风寒湿痹型LIDP患者286例。采用随机数字表法将患者分为对照组（n=143）和研究组（n=143），对照组给予常规治疗，研究组在对照组基础上联合独活寄生汤加减治疗，比较两组临床疗效，比较两组治疗前、治疗30 d后生活质量、自由基代谢及睡眠质量情况，记录两组治疗期间不良反应情况。结果：研究组临床总有效率为93.71%，显著高于对照组的66.43%（P<0.05）。治疗30 d后，两组患者超氧化物歧化酶（SOD）水平升高，且研究组高于对照组（P<0.05），丙二醛（MDA）水平降低，且研究组低于对照组（P<0.05）。两组患者治疗前、治疗30d后活力（VT）、社会功能（SF）评分比较无差异（P>0.05），两组患者治疗30d后躯体功能（PF）、躯体疼痛（BP）、躯体角色（RP）、心理健康（MH）、总体健康（GH）以及情感角色（RE）评分均较治疗前升高，且研究组较对照组升高（P<0.05）。两组患者治疗30 d后匹兹堡睡眠质量指数（PSQI）评分均较治疗前降低，且研究组低于对照组（P<0.05）。两组患者治疗期间不良反应发生率比较无统计学差异（P>0.05）。结论：独活寄生汤加减治疗风寒湿痹型LIDP患者疗效确切，其可有效改善患者生活质量、自由基代谢及睡眠质量，且安全性较好，具有一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of modified Duhuo Jisheng Decoction on quality of life, free radical metabolism and sleep quality of patients with wind-cold-dampness syndrome of lumbar intervertebral disc protrusion (LIDP). Methods: 286 patients with wind-cold-dampness type of LIDP who were treated in the department of Orthopedics, Hainan Hospital of Traditional Chinese Medicine from January 2012 to December 2017 were selected. Patients were divided into control group (n=143) and study group (n=143) by ran- dom number table method. Patients in control group were given routine western medicine treatment. Patients in study group were treated with Duhuo Jisheng Decoction on the basis of control group. The clinical effects of the two groups were compared. The quality of life, free radical metabolism and sleep quality of the two groups were compared before and 30 d after treatment. The adverse reactions of the two groups during treatment were recorded. Results: The total effective rate was 93.71% in the study group, which was significantly higher than 66.43% in the control group (P<0.05). At 30d after treatment, the superoxide dismutase (SOD) was increased in both groups, and the study group was higher than the control group (P<0.05), the malondialdehyde (MDA) level was decreased, and the study group was lower than the control group (P<0.05). There was no statistical difference in the vitality (VT) and social function (SF) scores before and 30d after treatment between the two groups (P>0.05). The body function (PF),body pain (BP), body role (RP), mental health (MH), overall health (GH) and emotional role (RE) scores of the two groups 30d after treatment were all higher than before treatment, the study group was higher than the control group (P<0.05). Pittsburgh sleep quality index (PSQI) in both groups 30 d after treatment was lower than before treatment, and the study group was lower than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Duhuo Jisheng Decoction is effective in treating patients with wind-cold-damp- ness syndrome of LIDP. It can effectively improve the quality of life, free radical metabolism and sleep quality. It is safety, and it has a certain clinical value. |
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