| 张 越,袁 芳,王 蓁,韩 毅,秦廷芹.子宫内膜癌C-erbB-2和TTF-1的表达及其与预后的关系[J].现代生物医学进展英文版,2019,19(8):1517-1521. |
| 子宫内膜癌C-erbB-2和TTF-1的表达及其与预后的关系 |
| Expression of C-erbB-2 and TTF-1 in the Endometrial Carcinoma and their Relationship with the Clinical Prognosis |
| Received:September 16, 2018 Revised:October 12, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.08.026 |
| 中文关键词: 子宫内膜癌 C-erbB-2 TTF-1 |
| 英文关键词: Endometrial carcinoma C-erbB -2 TTF-1 |
| 基金项目: |
| Author Name | Affiliation | E-mail | | ZHANG Yue | Qingdao University Medical College, Qingdao, Shandong, 266000, China | dittoyueyue@163.com | | YUAN Fang | Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China | | | WANG Zhen | Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China | | | HAN Yi | Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China | | | QIN Ting -qin | Qingdao University Medical College, Qingdao, Shandong, 266000, China | |
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| 中文摘要: |
| 摘要 目的：探讨子宫内膜癌组织中C-erbB-2和TTF-1的表达及其与患者临床预后的关系。方法：应用免疫组化S-P法检测正常子宫内膜组织、子宫内膜不典型增生组织、子宫内膜癌组织中C-erbB-2与TTF-1的表达，并分析二者与子宫内膜癌临床病理特征及患者临床预后的关系。结果：子宫内膜癌组织、子宫内膜不典型增生组织、正常子宫内膜组织中C-erbB-2的阳性表达率分别为56.65%、36.67%、16.67%（P＜0.05），TTF-1的的阳性表达率分别为 33.75%、53.33%、70.00%（P＜0.05）。C-erbB-2的阳性表达与子宫内膜癌的临床病理分期、组织分化、肌层浸润及有无淋巴结转移呈显著正相关(P＜0.05)，与其病理类型无显著相关性(P＞0.05)。TTF-1的阳性表达与子宫内膜癌的病理分期、组织分化、肌层浸润深度负相关(P＜0.05)，但与有无淋巴结转移及病理类型均无显著相关性(P＞0.05)。C-erbB-2和TTF-1在子宫内膜癌组织中表达无明显相关性(P=0.303)。子宫内膜癌中C-erbB-2阳性表达者五年生存率(80.90%)显著低于C-erbB-2阴性表达者(93.80%)(P＜0.05)，TTF-1阳性表达者五年生存率(87.70%)略高于TTF-1阴性表达者(85.70%)，但差异无统计学意义(P＞0.05)。结论：子宫内膜癌组织中C-erbB-2的表达显著上调，而TTF-1的表达明显下调，二者表达异常均参与了子宫内膜癌的发生和发展，且C-erbB-2的表达上调与子宫内膜癌患者的不良预后相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of human epidermai growth factor recepetor-2 (C-erbB-2) and thyroid transcription factor-1(TTF-1) in endometrial carcinoma and its relationship of prognosis. Methods: To examine the expression of normal endometrium, atypical hyperplasia and endometrial carcinoma by immunohistochemistry, and to discuss both relation to clinical pathological feature and prognosis of endometrial carcinoma. Results: The expression rates of C-erbB-2 in endometrial carcinoma, atypical hyperplasia and normal endometrium were 56.65%, 36.67%, 16.67% (P＜0.05), and the expression rates of TTF-1 were 33.75%, 53.33%, 70.00% (P＜0.05). The positive expression of C-erbB-2 was associated with pathological stage, histological grade, myometrial infiltration and lymphatic metastasis(P＜0.05), while not with pathological type(P＞0.05). The negative expression of TTF-1was correlated with pathological stage, histological grade, myometrial infiltration(P＜0.05), while not with lymphatic metastasis and pathological type (P＞0.05). The expression of C-erbB-2 and TTF-1 in endometrial carcinoma was not associated (P=0.303 ). The 5-year survival rate was lower in C-erbB-2 positive group than that in negative group (P＜0.05). But there was on difference of 5-year survival rate between TTF-1 positive and negative group (P＞0.05). Conclusion: The expression of C-erbB-2 of endometrial carcinoma tissues was up-regulatied, while the expression of TTF-1 was down-regulated. Both C-erbB-2 and TTF-1 were involved in the occurrence and development of endometrial carcinoma. The up-regulation of C-erbB-2 was associated with the poor prognosis of endometrial carcinoma. |
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