| 杨宇杰,陈大兴,潘华锋,陶立轩,郭 宁,王 杰.自发性气胸患者术后并发胸腔积液与肺部感染、胸水葡糖糖水平的相关性分析[J].现代生物医学进展英文版,2019,19(7):1285-1289. |
| 自发性气胸患者术后并发胸腔积液与肺部感染、胸水葡糖糖水平的相关性分析 |
| Correlation Analysis of Postoperative Pleural Effusion and Pulmonary Infection and Glu Level in Patients with Spontaneous Pneumothorax |
| Received:August 07, 2018 Revised:August 31, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.07.018 |
| 中文关键词: 自发性气胸 胸腔积液 肺部感染 胸水葡糖糖 |
| 英文关键词: Spontaneous pneumothorax Pleural effusion Pulmonary infection Hydrothorax Glu |
| 基金项目:湖北省科技计划基金项目（WJ2015HB25） |
| Author Name | Affiliation | E-mail | | YANG Yu-jie | Department of Cardio-Thoracic Surgery, Pu Ren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, 430081, China | 409034963@qq.com | | CHEN Da-xing | Department of Cardio-Thoracic Surgery, Pu Ren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, 430081, China | | | PAN Hua-feng | Department of Cardio-Thoracic Surgery, Pu Ren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, 430081, China | | | TAO Li-xuan | Department of Cardio-Thoracic Surgery, Pu Ren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, 430081, China | | | GUO Ning | Department of Cardio-Thoracic Surgery, Pu Ren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, 430081, China | | | WANG Jie | Department of Cardio-Thoracic Surgery, Pu Ren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, 430081, China | |
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| 中文摘要: |
| 摘要 目的：探讨自发性气胸患者术后并发胸腔积液与肺部感染、胸水葡糖糖（Glu）水平的相关性，为自发性气胸患者术后并发胸腔积液的预防诊治提供参考。方法：选择我院2016年6月至2018年3月收治的96例行胸腔镜手术的自发性气胸患者作为研究对象，按照术后是否并发胸腔积液将其分为对照组和观察组两组，其中对照组患者56例，术后无并发症，观察组患者40例，术后并发胸腔积液。采用单因素分析法对两组患者的一般资料进行分析，并通过Pearson分析法对上述资料进行相关性分析。对术后肺部感染患者的病原菌分布及构成比进行分析，观察两组患者手术前后外周血炎症因子变化。结果：观察组患者感染率、住院时间、术后恢复时间、胸水Glu水平明显高于对照组，差异显著具有统计学意义（P<0.05）；对上述具有显著性差异的一般资料进行Pearson分析显示，肺部感染与SP患者术后并发胸腔积液呈现正相关，胸水Glu与SP患者术后并发胸腔积液呈现负相关（P<0.05）。17例感染病例中，革兰氏阴性菌为11例，构成比64.71%，革兰氏阳性菌为6例，构成比35.29%，无真菌感染病例发生。两组患者治疗前各外周血炎症因子水平差异不具有统计学意义，具有可比性（P>0.05）；两组患者治疗后降钙素原（PCT）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）以及白细胞介素-10（IL-10）水平均明显升高，且观察组患者上述指标升高更为显著，差异具有统计学意义（P<0.05）。结论：自发性气胸患者术后并发胸腔积液与胸水Glu水平呈现负相关，与肺部感染呈现正相关，且肺部感染患者中革兰氏阴性菌相对较多，对自发性气胸患者术后并发胸腔积液临床诊治具有一定的借鉴意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between postoperative pleural effusion and pulmonary infection, pleural glu- cosamine (Glu) level in patients with spontaneous pneumothorax, and to provide reference for the diagnosis and treatment of postopera- tive pleural effusion in patients with spontaneous pneumothorax. Methods: A total of 96 patients with spontaneous pneumothorax who underwent thoracoscopic surgery from June 2016 to March 2018 in our hospital were selected as the study subjects. They were divided into a control group and an observation group according to whether or not they had pleural effusion after operation, there were 56 patients in the control group and no postoperative complications. There were 40 patients in the observation group and postoperative pleural effu- sion. Single factor analysis was used to analyze the general data of the two groups of patients, and the correlation analysis was performed on the above data by Pearson analysis. The distribution of pathogenic bacteria and the composition ratio of patients with postoperative pulmonary infection were analyzed to observe the changes of inflammatory factors in peripheral blood before and after surgery. Results: In the observation group, the infection rate, length of stay, postoperative recovery time, and pleural Glu level were significantly higher than those in the control group. The difference was statistically significant(P<0.05); Pearson analysis of the general data with significant differences indicated that there was a positive correlation between pulmonary infection and postoperative pleural effusion in patients with SP, and there was a negative correlation between pleural effusion and postoperative pleural effusion in SP patients (P<0.05). Of the 17 in- fections, 11 were Gram-negative bacteria, 64.71% of the constituents were Gram-negative bacteria, 6 were Gram-positive bacteria, 35.29% of the constituents were Gram-positive bacteria, and no fungal infection occurred. The levels of inflammatory cytokines before treatment in the two groups were not statistically significant and comparable(P>0.05); the levels of Calcitonin(PCT), interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) were significantly increased after treatment in both groups, the above indicators in the ob- servation group increased more significantly, the difference was statistically significant(P<0.05). Conclusion: Postoperative pleural effusion in patients with spontaneous pneumothorax is negatively correlated with Glu and pleural effusion levels. It is positively correlated with lung infections. Gram-negative bacteria are more common in patients with pulmonary infections, it can be used as a reference for the clin- ical diagnosis and treatment of postoperative pleural effusion in patients with spontaneous pneumothorax. |
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