| 赵廷丽,刘 阳,李征征,王 来,孙 立,袁胜涛.抗凋亡蛋白Mcl-1及其抑制剂的研究进展[J].现代生物医学进展英文版,2019,19(6):1184-1187. |
| 抗凋亡蛋白Mcl-1及其抑制剂的研究进展 |
| Research Progress of Anti-apoptotic Protein Mcl-1 and its Inhibitors |
| Received:April 30, 2018 Revised:May 26, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.06.041 |
| 中文关键词: Mcl-1蛋白 Bcl-2蛋白 抗凋亡 抑制剂 |
| 英文关键词: Mcl-1 protein Bcl-2 protein Anti apoptosis Inhibitor |
| 基金项目:国家自然科学基金项目（81773766） |
| Author Name | Affiliation | E-mail | | ZHAO Ting-li | China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China | 1553905262@qq.com | | LIU Yang | China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China | | | LI Zheng-zheng | China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China | | | WANG Lai | China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China | | | SUN Li | China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China | | | YUAN Sheng-tao | China Medicine University, Jiangsu Center for New Drug Screening, Nanjing, Jiangsu, 210009, China | |
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| 中文摘要: |
| 摘要：骨髓细胞白血病蛋白Mcl-1是Bcl-2家族蛋白中重要的抗凋亡蛋白成员，其在多种恶性肿瘤（急性细胞性白血病、多发性骨髓瘤等）中都具有高表达的特点，导致肿瘤细胞对传统化疗药物及Bcl-2抑制剂产生耐药性。Mcl-1作为抗肿瘤药物研发的重要靶点正日益受到相关研究人员的关注，其中Mcl-1新型抑制剂以及联合抑制剂的研究取得了较大进展。本文将对Mcl-1蛋白结构和功能以及相关抑制剂的研究做更深入的分析和总结。 |
| 英文摘要: |
| ABSTRACT: Bone marrow cell leukemia protein Mcl-1 is an important member of the anti-apoptotic protein in the Bcl-2 family protein, and has high expression in many kinds of malignant tumor (acute cell leukemia, multiple myeloma, etc), resulting in drug resistance to traditional chemotherapeutic agents and Bcl-2 inhibitors. As an important target for the research and development of antitumor drugs, Mcl-1 is increasingly concerned by the researchers. Great progress has been made in the research of new Mcl-1 inhibitors and joint inhibitors. This article will make a more in-depth analysis of the structure and function of Mcl-1 protein and related inhibitors, and results of the study will be of great significance for the treatment of cancer. |
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