Article Summary
熊 伟,张 莉,董 科,古 春,俞小炯.恩替卡韦联合聚乙二醇干扰素α-2b治疗HBeAg阳性乙肝的临床研究[J].现代生物医学进展英文版,2019,19(6):1091-1094.
恩替卡韦联合聚乙二醇干扰素α-2b治疗HBeAg阳性乙肝的临床研究
Clinical Study of Entecavir Combined with Peginterferon α -2b in the Treatment of HBeAg Positive Hepatitis B
Received:August 10, 2018  Revised:August 31, 2018
DOI:10.13241/j.cnki.pmb.2019.06.019
中文关键词: 恩替卡韦  聚乙二醇干扰素α-2b  HBeAg阳性  乙肝  血清学转换  转阴率  安全性
英文关键词: Entecavir  Peginterferon α-2b  HBeAg-positive  Hepatitis B  Serological conversion  Seroconversion rate  Safety
基金项目:四川省卫生厅科研基金项目(30520010065)
Author NameAffiliationE-mail
XIONG Wei Department of Hepatobiliary Surgery, Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, China xiwoqu@163.com 
ZHANG Li Department of Elderly Gastroenterology, Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, China  
DONG Ke Department of Hepatobiliary Surgery, Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, China  
GU Chun Department of Hepatobiliary Surgery, Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, China  
YU Xiao-jiong Department of Hepatobiliary Surgery, Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, China  
Hits: 921
Download times: 556
中文摘要:
      摘要 目的:探讨恩替卡韦联合聚乙二醇干扰素α-2b治疗乙型肝炎E抗原(HBeAg)阳性乙肝的临床疗效、安全性及对相关标志物的影响。方法:选取2015年10月至2017年10月我院收治的97例HBeAg阳性乙肝患者,采用随机数字表法将其分为对照组48例和观察组49例。对照组患者采用单纯皮下注射聚乙二醇干扰素α-2b注射剂治疗,观察组采用恩替卡韦联合聚乙二醇干扰素α-2b治疗。比较两组患者治疗后的临床疗效、谷草转氨酶(AST)、丙氨酸转氨酶(ALT)、乙肝病毒的脱氧核糖核酸(HBV-DNA)含量以及ALT复常率、HBeAg血清转换率、HBV-DNA转阴率及不良反应发生率。结果:观察组总治疗有效率为91.84%,明显高于对照组的77.55%( P<0.05);治疗后,观察组的ALT、AST、HBV-DNA含量明显低于对照组(P<0.05),观察组的ALT复常率、HBeAg血清学转换率、HBV-DNA转阴率明显高于对照组(P<0.05);观察组治疗期间不良反应发生率为30.61%,与对照组的29.17%比较差异无统计学意义(P>0.05)。结论:恩替卡韦联合聚乙二醇干扰素α-2b治疗HBeAg阳性乙肝较单用干扰素的抗病毒治疗疗效更高,可降低传染性,用药安全性较好。
英文摘要:
      ABSTRACT Objective: To investigate the the clinical efficacy, safety and effects of entecavir combined with peginterferon α-2b in the treatment of hepatitis B E antigen (HBeAg) positive hepatitis B. Methods: 97 cases of HBeAg positive hepatitis B patients enrolled in our hospital from October 2015 to October 2017 were divided into control group (n=48) and observation group (n=49) by random number table methods. The control group was treated with subcutaneous injection of peginterferon α-2b, while the observation group was treated with entecavir combined with peginterferon alpha-2b. The clinical efficacy, the content of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and hepatitis B virus DNA (HBV-DNA), the conversion rate of HBeAg serological, the seroconversion rate of hepatitis B virus deoxyribonucleic acid (HBV-DNA), and the incidence of adverse reactions of the patients in the two groups after treatment was compared. Results: The total effective rate of observation group was 91.84%, which was significantly higher than that of control group (x2=8.50, P<0.05). After treatment, the contents of ALT, AST and HBV-DNA in observation group was significantly lower than those in control group(P<0.05), the repetition rate of ALT, the conversion rate of HBeAg serological,the seroconversion rate of HBV-DNA rate was significantly higher than those of the control group (P<0.05). After treatment, the incidence of adverse reactions in the observation group was 30.61%, compared with 29.17% in the control group, the difference was not statistically significant (P>0.05). Conclusion: The efficacy of entecavir combined with peginterferon α-2b in the treatment of HBeAg positive hepatitis B is better than that of interferon alone, it can reduce the contagiousness and has a good safty.
View Full Text   View/Add Comment  Download reader
Close