| 蔡珠虹,刘天佳,赵 静,宋禹杉,蒋 栋.颈动脉斑块易损性与血脂指标、炎症因子和冠心病的关系[J].现代生物医学进展英文版,2019,19(4):661-664. |
| 颈动脉斑块易损性与血脂指标、炎症因子和冠心病的关系 |
| Relationship between Carotid Plaque Vulnerability and Blood Lipids,Inflammatory Factors and Coronary Heart Disease |
| Received:June 23, 2018 Revised:July 18, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.04.012 |
| 中文关键词: 颈动脉斑块 易损性 血脂指标 炎症因子 冠心病 关系 |
| 英文关键词: Carotid plaques Vulnerability Blood lipid index Inflammatory factor Coronary heart disease Relationship |
| 基金项目:上海市科学技术委员会基金项目（13411426300） |
| Author Name | Affiliation | E-mail | | CAI Zhu-hong | Department of Ultrasound, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, 200433, China | cqgnde@163.com | | LIU Tian-jia | Department of Ultrasound, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, 200433, China | | | ZHAO Jing | Department of Pathology, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, 200433, China | | | SONG Yu-shan | Department of Ultrasound, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, 200433, China | | | JIANG Dong | Department of Ultrasound, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai, 200433, China | |
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| 中文摘要: |
| 摘要 目的：探讨颈动脉斑块易损性与血脂指标、炎症因子和冠心病的关系。方法：选择2016年1月-2018年1月在我院进行治疗的颈动脉斑块患者95例为研究对象，所有患者均进行颈动脉超声检查，根据超声检查结果的斑块性质将患者分为稳定组（n=43）和易损组（n=52）。检测两组患者的总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等血脂指标，对比两组患者的血清白介素-8（IL-8）、超敏C反应蛋白（hs-CRP）、细胞黏附因子-1（ICAM-1）、趋化因子（RANTES）水平，统计两组患者的冠心病发生率。结果：易损组患者的TC、TG、LDL-C均高于稳定组，HDL-C低于稳定组，组间比较差异有统计学意义（P<0.05）。易损组患者的IL-8、hs-CRP、ICAM-1、RANTES水平均高于稳定组，组间比较差异有统计学意义（P<0.05）。稳定组冠心病发生率为53.49%（23/43），易损组冠心病发生率为78.85%（41/52），两组冠心病发生率比较差异有统计学意义（P<0.05）。结论：颈动脉斑块易损性可导致患者的血脂指标、血清炎症因子指标进一步恶化，也会增加患者出现冠心病的发生机率。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between carotid plaque vulnerability and blood lipids, inflammatory factors and coronary heart disease. Methods: 95 patients with carotid artery plaque who were treated in our hospital from January 2018 to January 2016 were selected as the subjects. All the patients were examined by carotid ultrasound, and the patients were divided into stable group (n=43) and unstable group(n=52) according to the plaque character of ultrasonic examination results. Blood lipid indexes such as total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in two groups were detected. The serum levels of interleukin -8 (IL-8), hypersensitive C reactive protein (hs-CRP), cell adhesion factor -1 (ICAM-1) and chemokine (RANTES) were compared in the two groups, and the incidence of coronary heart disease in the two groups was statisti- cally analyzed. Results: The TC, TG and LDL-C of the patients in the unstable group were higher than those in the stable group, while HDL-C was lower than that in the stable group, and the differences between the two groups were statistically significant(P<0.05). The levels of IL-8, hs-CRP, ICAM-1 and RANTES in the unstable group were all higher than those in the stable group, and the difference be- tween the two groups was statistically significant(P<0.05). The incidence of coronary heart disease in the stable group was 53.49% (23/43), and the incidence of coronary heart disease in the vulnerable group was 78.85% (41/52), there was a significant difference in the incidence of coronary heart disease in the two groups (P<0.05). Conclusion: The vulnerability of carotid plaque can lead to further deteri- oration of blood lipid index and serum inflammatory factor index, and also increase the incidence of coronary heart disease. |
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