| 刘 屹,朱亚宁,丰 航,张鑫雨,李 茁.综合性医院肿瘤相关感染病原菌分布及耐药性分析[J].现代生物医学进展英文版,2019,19(2):284-289. |
| 综合性医院肿瘤相关感染病原菌分布及耐药性分析 |
| Distribution of Pathogenic Bacteria and Drug Resistance of Tumor related Infections in General Hospitals |
| Received:July 06, 2018 Revised:July 31, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.02.018 |
| 中文关键词: 肿瘤 感染 病原菌分布 药敏结果 经验性用药 |
| 英文关键词: Tumor Infection Pathogen distribution Drug sensitivity Empirical clinical medication |
| 基金项目:国家自然科学基金项目(81402012) ；陕西省自然科学基金项目（2015JQ8321）；陕西省人民医院科技发展孵化基金资助项目(2016YX-11) |
| Author Name | Affiliation | E-mail | | LIU Yi | Department of Oncology, Shaanxi provincial people's hospital, Xi'an, Shaanxi, 710068, China | liuyi926999@yeah.net | | ZHU Ya-ning | Department of pharmacy, Shaanxi provincial people's hospital, Xi'an, Shaanxi, 710068, China | | | FENG Hang | Department of pharmacy, Shaanxi provincial people's hospital, Xi'an, Shaanxi, 710068, China | | | ZHANG Xin-yu | Fourth Cadet Brigade, Air Force Medical University, Xi'an, Shaanxi, 710032, China | | | LI Zhuo | Department of pharmacy, Shaanxi provincial people's hospital, Xi'an, Shaanxi, 710068, China | |
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| 中文摘要: |
| 摘要 目的：通过对某院住院肿瘤患者感染的病原菌分布情况及耐药性分析，为肿瘤相关感染患者的经验性抗感染治疗提供参考。方法：对2015年细菌培养结果阳性的157例肿瘤内科住院患者的感染情况进行统计分析。结果：肿瘤内科患者的感染率为22.62%，分离出病原菌436株，其中革兰阴性菌占比58.26％，检出的金黄色葡萄球菌中MRSA的检出率为50%，粪肠球菌对万古霉素的敏感率为80%，屎肠球菌对万古霉素的敏感率为97.22%。主要G-杆菌中大肠埃希菌对阿米卡星耐药率1.79%，对碳青霉烯类、哌拉西林他唑巴坦耐药率为6.25%、26.79%；肺炎克雷伯菌对碳青霉烯类的耐药率25.58%-38.10%，对头孢哌酮舒巴坦耐药率15%。白色念珠菌对唑类耐药率<10%。结论：医院必须加强对常见细菌的耐药率的动态监测，降低细菌耐药率和多重耐药菌的产生。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the distribution of pathogens and drug resistance of patients with tumors in hospitals, and to pro- vide reference for empirical anti-infective treatment of patients with tumor-related infections. Methods: Statistical analysis was performed on the infection status of 157 inpatients with tumors who were positive in bacterial culture in 2015. Results: The infection rate of tumor patients was 22.62%, and 436 strains of pathogens were isolated, of which Gram-negative bacteria accounted for 58.26%, and the detec- tion rate of MRSA in Staphylococcus aureus was 50%. The sensitivity of Enterococcus faecalis to vancomycin is 80%, and the sensitivity of Enterococcus faecium to vancomycin is 97.22%. The resistance rate of Escherichia coli to amikacin in the main G-bacilli was 1.79%, and the resistance rate to carbapenems and piperacillin tazobactam was 6.25% and 26.79%; Klebsiella pneumoniae The resistance rate of carbapenems was 25.58%-38.10%, and the resistance rate to cefoperazone sulbactam was 15%. Candida albicans resistance to azoles <10%. Conclusion: The hospital must strengthen the dynamic monitoring of the resistance rate of common bacteria, reduce the rate of bacterial resistance and the production of multi-drug resistant bacteria. |
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