| 黄振宜,汪 洋,王洪江,罗洞波,吕红博.食管癌组织中β-catenin、PTTG及c-myc的表达及其临床意义*[J].现代生物医学进展英文版,2019,19(1):108-111. |
| 食管癌组织中β-catenin、PTTG及c-myc的表达及其临床意义* |
| Expression and Clinical Significance of β-catenin, PTTG and c-myc in Esophageal Carcinoma Tissue* |
| Received:April 27, 2018 Revised:May 20, 2018 |
| DOI：10.13241/j.cnki.pmb.2019.01.023 |
| 中文关键词: 食管癌 β-链接素 垂体肿瘤转化基因 原癌基因 表达 临床意义 |
| 英文关键词: Esophageal carcinoma β-catenin Pituitany tumor transforming gene C-myc Expression Clinical significance |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2012211A415） |
| Author Name | Affiliation | E-mail | | HUANG Zhen-yi | Department of Thoracic Surgery, Third Clinical Medical College of Xinjiang Medical University/Cancer Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, 830001, China | vrtmm3@163.com | | WANG Yang | Department of Thoracic Surgery, Third Clinical Medical College of Xinjiang Medical University/Cancer Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, 830002, China | | | WANG Hong-jiang | Department of Thoracic Surgery, Third Clinical Medical College of Xinjiang Medical University/Cancer Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, 830003, China | | | LUO Dong-bo | Department of Thoracic Surgery, Third Clinical Medical College of Xinjiang Medical University/Cancer Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, 830004, China | | | LV Hong-bo | Department of Thoracic Surgery, Third Clinical Medical College of Xinjiang Medical University/Cancer Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, 830005, China | |
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| 中文摘要: |
| 摘要 目的：探讨食管癌组织中?茁-链接素（β-catenin）、垂体肿瘤转化基因（PTTG）、原癌基因（c-myc）的表达及其临床意义。方法：将2015年6月至2017年6月期间新疆医科大学附属肿瘤医院手术切除的食管鳞癌标本98例作为观察组，同时切取癌旁正常黏膜组织标本98例作为对照组，观察两组β-catenin、PTTG、c-myc蛋白表达情况，对比观察组不同病理特征患者β-catenin、PTTG、c-myc蛋白阳性表达情况，并分析食管癌组织中PTTG与β-catenin、c-myc蛋白表达的相关性。结果：观察组β-catenin、PTTG、c-myc蛋白表达阳性率均显著高于对照组，差异有统计学意义（P<0.05）。观察组β-catenin、PTTG、c-myc蛋白阳性表达均与患者的TNM分期和淋巴结转移有关（P<0.05），与患者的性别、年龄、肿瘤直径以及分化程度无关（P>0.05）。食管癌组织中PTTG与β-catenin、c-myc蛋白表达均呈正相关（P<0.05）。结论：食管癌患者β-catenin、PTTG、c-myc蛋白表达阳性率较高，与患者的TNM分期和淋巴结转移有关，且PTTG与β-catenin、c-myc蛋白表达呈正相关，三者可作为早期诊断和评估食管癌预后的重要参考指标。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expression and clinical significance of β-catenin(β-catenin), pituitary tumor transforming gene(PTTG), c-myc(c-myc) in esophageal carcinoma tissue. Methods: 98 specimens of esophageal squamous cell carcinoma which were excised from operation in Cancer Hospital Affiliated to Xinjiang Medical University from June 2015 to June 2017 were taken as an observation group, at the same time, 98 specimens of normal mucosa tissue adjacent to the carcinoma were taken as the control group. The expression of β-catenin, PTTG and c-myc protein in two groups was observed, the positive expression of β-catenin, PTTG and c-myc protein in patients with different pathological features was compared, and the correlation between the expression of PTTG and the expression of β-catenin and c-myc protein in esophageal carcinoma was analyzed. Results: The positive rate of the expression of β-catenin, PTTG and c-myc in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P<0.05). The positive expression of β-catenin, PTTG and c-myc protein in the observation group was related to the TNM stage and lymph node metastasis (P<0.05), which was not related to the sex, age, tumor diameter and the degree of differentiation (P>0.05). The expression of PTTG in esophageal carcinoma tissue was positively correlated with the expression of β-catenin and c-myc protein (P<0.05). Conclusion: The positive rate of expression of β-catenin, PTTG and c-myc protein are higher in patients with esophageal carcinoma, which is associated with TNM stage and lymph node metastasis of the patients, and PTTG is positively correlated with the expression of β-catenin and c-myc protein, the three can be used as important reference indexes for the early diagnosis and evaluation of the prognosis of esophageal carcinoma. |
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