| 马 科,寇 艳,卢 蓉,贾鲲鹏,赵力芳.匹多莫德对抗生素相关性腹泻患儿的免疫功能及炎症反应的影响[J].现代生物医学进展英文版,2018,(24):4786-4789. |
| 匹多莫德对抗生素相关性腹泻患儿的免疫功能及炎症反应的影响 |
| Effects of Pidotimod on Immune Function and Inflammatory Response of Children with Antibiotic Associated Diarrhea |
| Received:May 12, 2018 Revised:June 08, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.24.042 |
| 中文关键词: 匹多莫德 抗生素相关性腹泻 免疫球蛋白 T细胞亚群 肿瘤坏死因子- (TNF-α) 白介素-6(IL-6) |
| 英文关键词: Pidotimod Antibiotic associated diarrhea(ADD) Immunoglobulin Tumor necrosis factor-α(TNF-α) Interleukin-6(IL-6) |
| 基金项目:陕西省自然科学基金项目(Y2002C35) |
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| 中文摘要: |
| 摘要 目的：研究匹多莫德辅助治疗抗生素相关性腹泻(ADD)患儿的临床疗效及对患儿免疫功能和炎症反应的影响。方法：研究对象选取我院2015年10月到2016年12月间收治的ADD患儿96例，采用随机数字法将其分为对照组和观察组，每组各48例。两组患儿均接受常规对症治疗，观察组患儿在此基础上口服匹多莫德治疗。比较两组患儿的治疗总有效率和复发率、治疗前后的免疫功能指标和血清肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)水平的变化。结果：观察组的治疗总有效率(93.75%)明显高于对照组(72.92%)(P=0.00)，复发率明显低于对照组(P=0.00)。治疗后，观察组的血清IgA、IgG、IgM水平、CD3+、CD4+及CD4+/CD8+比值均明显高于对照组(P<0.01)，CD8+、血清TNF-α和IL-6水平均明显低于对照组(P<0.01)。结论：匹多莫德能够有效改善ADD患儿的免疫功能，抑制机体炎症反应，且治疗安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To study the efficacy of pidotimod in the treatment of children with antibiotic associated diarrhea (ADD) and effect on the immune function and inflammatory response. Methods: 96 cases of ADD patients in our hospital from October 2015 to December 2016 were selected and randomly divided into the control group and the observation group, with 48 cases in each group. Both groups were given conventional symptomatic treatment, on the basis of this, the observation group was treated by oral pidotimod treat- ment. The total effective rate and recurrence rate, changes of serum tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) before and after treatment were compared between two groups. Results: The total efficiency of observation group(93.75%) was significantly higher than that of the control group(72.92%)(P=0.00); the recurrence rate of observation group was significantly lower than that of the control group (P=0.00); after treatment, the serum IgA, IgG group, IgM levels, CD3+, CD4+, and CD4+/CD8+ ratio were significantly higher than those of the control group(P<0.01), CD8+, serum levels of TNF-α and IL-6 were significantly lower than those of the control group(P<0.01). Conclusion: Pidotimod could effectively improve the immune function and inhibit the inflammatory response of patients with ADD with high safety. |
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