| 李冬萍,李舜君,山永仪,邹冬梅,田 立.仙灵骨葆胶囊治疗骨质疏松疼痛患者的疗效及其对骨密度及骨代谢的影响[J].现代生物医学进展英文版,2018,(24):4756-4759. |
| 仙灵骨葆胶囊治疗骨质疏松疼痛患者的疗效及其对骨密度及骨代谢的影响 |
| Effect of Xianling Gubao Capsule on Bone Mineral Density and Bone Metabolism in Treatment of Patients with Osteoporosis Pain |
| Received:May 26, 2018 Revised:June 21, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.24.035 |
| 中文关键词: 仙灵骨葆胶囊 骨质疏松症 疼痛 骨密度 骨代谢 |
| 英文关键词: Xianling Gubao Capsule Osteoporosis Pain Bone mineral density Bone metabolism |
| 基金项目:青海省自然科学基金项目（0124024） |
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| 中文摘要: |
| 摘要 目的：探讨仙灵骨葆胶囊治疗骨质疏松疼痛患者的疗效，并分析其对骨密度及骨代谢的影响，为临床用药提供依据。方法：研究对象为我院2015年6月-2017年7月期间收治的60例骨质疏松症疼痛患者。根据治疗方案的不同将患者均分为对照组和观察组各30例。对照组患者采用常规西医治疗，观察组在对照组基础上加用仙灵骨葆胶囊治疗，两组均治疗6个月。治疗前及治疗6个月后（治疗后）采用视觉模拟量表（VAS）评分对患者的疼痛程度进行评价。评价并比较两组疗效。分别于治疗前、治疗后对所有患者腰椎、股骨颈骨密度以及血清N端中段骨钙素（N-MID）、骨钙素（BGP）以及I型胶原羧基末端交联肽（β-CTX）进行检测。结果：治疗后，观察组患者VAS评分明显低于对照组（P<0.05），且观察组总有效率为93.33%（28/30），高于对照组的73.33%（22/30）（P<0.05）。治疗后，两组患者腰椎、股骨颈骨密度均明显增加，且观察组患者腰椎骨密度明显高于对照组（P<0.05）。治疗后，两组患者β-CTX水平均明显降低，BGP水平均明显升高，且观察组β-CTX水平明显低于对照组，而BGP水平明显高于对照组（P<0.05），两组患者治疗前后N-MID水平均无明显变化（P>0.05）。结论：仙灵骨葆胶囊治疗骨质疏松症疼痛患者疗效显著，能够减轻疼痛并改善骨密度及骨代谢。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the curative effect of Xianling Gubao Capsule in treatment of patients with osteoporosis pain, and analyze its effects on bone mineral density and bone metabolism, and to provide evidence for clinical medication. Methods: A total of 60 patients with osteoporosis pain, who were admitted in Xining First People's Hospital from June 2015 to July 2017, were selected and were divided into control group(n=30) and observation group(n=30) according to different treatment regimen. The control group was treated with conventional western medicine, while the observation group was treated with Xianling Gubao Capsule on the basis of the control group's therapy. The two groups were treated for 6 months. Visual analogue scale (VAS) was used to evaluate the pain degree of the patients before treatment and 6 months after treatment. The curative effects of the two groups were evaluated and compared. The bone mineral density of lumbar vertebrae and femoral neck, N-mid fragment of osteocalcin (N-MID), bone gla protein (BGP) and β-type I collage cross-linked-telopeptide (β-CTX) were detected before and after treatment. Results: After treatment, the VAS score of the obser- vation group was significantly lower than that of the control group (P<0.05), and the total effective rate of the observation group was 93.33% (28/30), which was higher than 73.33% (22/30) of the control group (P<0.05); the bone mineral density of lumbar vertebrae and femoral neck of the two groups increased significantly, and the bone mineral density of lumbar vertebrae in the observation group was significantly higher than that in the control group(P<0.05); the level of β-CTX in the two groups was significantly decreased, and the level of BGP increased significantly, and the level of β-CTX in the observation group was significantly lower than that of the control group, while the level of BGP was significantly higher than that of the control group(P<0.05). There was no significant change in the level of N-MID between the two groups before and after treatment(P>0.05). Conclusion: Xianling Gubao Capsule is effective in the treatment of patients with osteoporosis pain. It can relieve pain and improve bone mineral density and bone metabolism of the patients with osteo- porosis pain. |
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