| 王建峰,张晨红,王 婉,吕日琅,郭 珍.舒血宁注射液联合多巴丝肼治疗帕金森病的临床疗效及对脑区血流量与血清炎性因子的影响[J].现代生物医学进展英文版,2018,(24):4748-4751. |
| 舒血宁注射液联合多巴丝肼治疗帕金森病的临床疗效及对脑区血流量与血清炎性因子的影响 |
| Clinical Efficacy of Shuxuening Injection Combined with Dopamine Hydrazine in the Treatment of Parkinson's Disease and Its Effect on the Cerebral Blood Flow and Serum Inflammatory Factors |
| Received:August 11, 2018 Revised:August 30, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.24.033 |
| 中文关键词: 帕金森病 舒血宁注射液 多巴丝肼 脑区血流量 炎性因子 |
| 英文关键词: Parkinson's disease Shuxuening injection Dopamine hydrazine Cerebral blood flow Inflammatory cytokines |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨舒血宁注射液联合多巴丝肼治疗帕金森病的疗效及对脑区血流量与血清炎性因子的影响。方法：选择我院2014年9月~2017年9月收治的94例帕金森病患者，按随机数表法分为对照组和研究组，每组47例。对照组予以多巴丝肼治疗，研究组在对照组基础上加以舒血宁注射液治疗。比较两组临床疗效，治疗前后UPDRSⅡ评分、UPDRSⅢ评分、UPDRS评分、脑区血流量、血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平的变化和不良反应的发生情况。结果：治疗后，研究组总有效率显著高于对照组(P<0.05)。两组治疗后UPDRSⅡ评分、UPDRSⅢ评分、UPDRS评分、血清IL-1β、IL-6、hs-CRP和TNF-α水平均较治疗前显著下降，且研究组以上指标均明显低于对照组(P<0.05)。两组治疗后脑区血流量均较治疗前显著增加，且研究组明显高于对照组(P<0.05)。两组均有恶心、头晕、失眠及呕吐发生，组间不良反应的发生率比较差异无统计学意义(P>0.05)。结论：舒血宁注射液联合多巴丝肼治疗帕金森病的临床疗效明显优于单用多巴丝肼，其能够促进脑部血流循环，调节脑区血流量，降低炎性因子的水平。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical Efficacy of shuxuening injection combined with dopamine hydrazine in the treatment of Parkinson's disease and its effect on the blood flow and serum inflammatory factors. Methods: 94 patients with Parkinson's disease who were treated from September 2014 to September 2017 in our hospital were selectd and divided into the control group and the re- search group according to the random number table method, with 47 cases in each group. The control group was treated with dopamine hydrazine, and the research group was treated with shuxuening injection based on the control group. Then the clinical curative effect, change of UP- DRS Ⅱ score, UPDRS Ⅲ score, UPDRS score, cerebral blood flow, the serum Interleukin-1β(IL-1β), interleukin 6 (IL-6), hypersensitive c-reactive protein(hs-CRP), tumor necrosis factor-α(TNF-α) levels before and after treatment, and the incidence of ad- verse reactions were compared between two groups. Results: After treatment, the total effective rate of research group was higher than that of the control group(P<0.05), the UPDRS Ⅱscore, UPDRS Ⅲscore, UPDRS score, serum levels of IL-1β, IL-6, hs-CRP and TNF-α of both group were significantly decreased than those before treatment, and the above indicators of research group were significantly lower than those of the control group(P<0.05). The blood flow in the brain area of both groups were significantly higher than those before treat- ment, which was more obviously in the research group than that in the control group(P<0.05). Nausea, dizziness, insomnia and vomiting were found in both groups, but significant difference was found between two groups(P>0.05). Conclusion: Shuxuening injection com- bined with dopamine hydrazine is more effective in the treatment of Parkinson's disease than dodohydrazine alone, it can promote the brain blood circula- tion, regulate the brain blood flow, reduce the levels of inflammatory factors. |
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