| 周 颖,杨 静,陆丽华,许琦华,赵 滨.胃癌患者HER2、VEGF、HIF-1a mRNA的表达与临床特点及预后的关系[J].现代生物医学进展英文版,2018,(24):4703-4706. |
| 胃癌患者HER2、VEGF、HIF-1a mRNA的表达与临床特点及预后的关系 |
| The Relationship between Serum Levels of HER2, VEGF, HIF-1a mRNA and Clinical Features and Prognosis of Gastric Cancer |
| Received:July 31, 2018 Revised:August 27, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.24.022 |
| 中文关键词: 胃癌 转移 复发 化疗 |
| 英文关键词: Gastric cancer Metastasis Recurrence Chemotherapy |
| 基金项目:浦东新区卫生系统学科带头培养计划项目(PWRd2016-12)；上海市卫生和计划生育委员会科研课题资助项目（2016460309）；上海中医药大学附属第七人民医院人才培养计划(BDX2016-01)，(XX2015-07)；(QMX2016-04) |
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| 中文摘要: |
| 摘要 目的：探讨胃癌患者血清中人表皮生长因子受体-2 (Human epithelial growth factor receptor 2, HER2)HER-2、血管内皮生长因子（Vascular endothelial growth factor ，VEGF）、低氧诱导因子-1α(hypoxia inducible factor-1, HIF-1α) mRNA水平与其临床特征及预后的关系。方法：选取我院2015年7月至2016年7月治疗的50例胃癌患者作为研究对象，采用荧光定量PCR检测血清中HER-2、VEGF、HIF-1α mRNA水平，探讨其与胃癌患者临床特点的关系，采用COX回归模型探讨HER-2、VEGF、HIF-1α mRNA表达与胃癌临床预后的关系。结果：胃癌组患者血清中HER2、VEGF、HIF-1α mRNA水平明显高于对照组患者，年龄越高、分化程度越低、临床分期晚、伴有淋巴结转移的胃癌患者血清中HER2、VEGF、HIF-1α mRNA水平明显高与相对应的患者，HER-2(P=0.04)、VEGF(P=0.03)、HIF-1α(P=0.04)是胃癌患者预后不良的独立危险因素。结论：胃癌组织中HER-2、VEGF、HIF-1α mRNA表达水平与胃癌恶性程度密切相关，是胃癌患者预后不良的独立危险因素 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between HER-2, VEGF and HIF-1α levels in serum and clinical prognosis in patients with gastric cancer. Methods: In our hospital from July 2015 to July 2016 in 50 cases of gastric cancer patients treated in our hos- pital as the research object, using SP method and enzyme-linked immunosorbent assay in gastric cancer tissues and serum HER-2, VEGF and HIF-1α mRNA levels to explore the relationship between serum and tissue of patients with gastric cancer HER-2, VEGF, HIF-1α mRNA levels and clinical characteristics of patients with COX. HER-2, VEGF, regression model to investigate the relationship between HIF-1α expression and clinical prognosis of gastric cancer. Results: The serum of gastric cancer patients in the HER2, VEGF and HIF-1α mRNA levels were significantly higher than that in control group, comparison of different age, degree of differentiation, clinical stage HER2, VEGF and HIF-1α mRNA levels in the serum of patients with age is higher, the lower the degree of differentiation, clinical stage, lymph node metastasis in patients with serum HER2, VEGF and HIF-1a mRNA significantly patients with high contrast, HER-2 (P=0.04), VEGF (P=0.03), HIF-1α(P=0.04) is an independent risk factor of poor prognosis of patients with gastric cancer. Conclusion: Serum levels of HER-2, VEGF and HIF-1a mRNA are closely related to the malignant degree of gastric cancer, which is an independent risk factor for poor prognosis of gastric cancer patients |
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