| 刁 岩,单昌友,赵 阳,靳耀锋,王子明,张淑群.非哺乳期乳腺炎的临床治疗探讨[J].现代生物医学进展英文版,2018,(24):4695-4698. |
| 非哺乳期乳腺炎的临床治疗探讨 |
| Clinical Treatment of Acute Non Lactation Mastitis |
| Received:July 30, 2018 Revised:August 24, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.24.020 |
| 中文关键词: 非哺乳期 急性乳腺炎 泼尼松 |
| 英文关键词: Non lactation Acute mastitis Prednisone |
| 基金项目:陕西省重点研发计划项目(2017SF-250) |
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| 中文摘要: |
| 摘要 目的：观察抗生素联合泼尼松双联药物冲击方法治疗非哺乳期急性乳腺炎的临床疗效。方法：选取本院乳腺外科2016年6月至2017年6月收治的105例非哺乳期急性乳腺炎患者作为观察对象，依照诊治顺序将其随机分为观察1组、观察2组以及对照组，每组35例患者。对照组给予口服左氧氟沙星，0.5 g/次，qd；观察1组在对照组的治疗方法中加用醋酸泼尼松片强的松20 mg，qd；观察2组在对照组的治疗方法中加用醋酸泼尼松片强的松40 mg，qd，三组均以14 d为一疗程。治疗1个疗程后，评价和比较各组治疗效果、血细胞数、好转时间、痊愈时、住院时间及不良反应的发生情况。结果：治疗后，观察1组、观察2组和对照组有效率分别为82.86%、97.14%和60.00%，观察2组有效率显著高于观察1组和对照组(P<0.05)。三组患者治疗后白细胞，中性粒细胞，淋巴细胞均较治疗前明显下降(P<0.05)，且观察2组以上指标显著低于观察1组和对照组(P<0.05)。观察2组的好转时间、痊愈时间及住院时间均明显短于观察1组和对照组(P＜0.05)，而观察1组的好转时间、痊愈时间及住院时间明显短于对照组(P＜0.05)。观察1组出现1例轻微胃肠道反应，1例胸闷，不良反应总发生率为5.71 %(2/35)；观察2组出现1例轻微胃肠道情况，不良反应总发生率为2.86 %(1/35)；对照组2例患者发生胸闷，1例患者出现轻微胃肠道不适，1例患者出现眩晕，不良反应发生率为11.43 % (4/35)，三组不良反应发生率比较差异均无统计学意义(P＞0.05)。结论：口服抗生素联合泼尼松治疗非哺乳期急性乳腺炎患者能提高临床疗效，且加大泼尼松口服剂量可进一步提高临床有效率，控制炎性进展，缩短痊愈时间。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of antibiotics combined with prednisone double-drug impact therapy in the treatment of non-lactating acute mastitis. Methods: 105 cases of patients with non-lactating acute mastitis admitted in our hospital from June 2016 to June 2017 were selected and divided into the observation group 1, observation group 2 and control group according to the order of diagnosis and treatment, with 35 patients in each group. The control group received oral levofloxacin, 0.5 g/time, qd; the ob- servation group 1 was given prednisone acetate prednisone 20 mg, qd on the basis of control group; the observation group 2 was treated by prednisone acetate prednisone 40 mg on the basis of control group, all three groups were treated for 14 days as a course of treatment. After one course of treatment, the effects of treatment, blood cell count, improvement time, recovery time, hospitalization time and inci- dence of adverse reactions in each group were evaluated and compared. Results: After treatment, the effective rate of observation group 1, observation group 2 and control group were 82.86%, 97.14% and 60.00%. The effective rate of observation group 2 was significantly higher than those of the observation group 1 and the control group(P<0.05). The white blood cells, neutrophils and lymphocytes of three groups were significantly lower than those before treatment(P<0.05), and the above indicators in observation group 2 were significantly lower thanthose of the observation group 1 and the control group(P<0.05). The improvement time, recovery time and hospitalization time of observation group 2 were significantly shorter than those of the observation group 1 and the control group (P<0.05), while the im- provement time, recovery time and hospitalization time of the observation group 1 were significantly shorter than the control group (P<0.05). One case of mild gastrointestinal reaction and one case of chest tightness were observed in observation group 1. The total incidence of adverse reactions was 5.71%(2/35). One case of mild gastrointestinal tract was observed in observation group 2, and the total incidence of adverse reactions was 2.86 %.(1/35); 2 patients in the control group developed chest tightness, 1 patient had mild gastrointestinal discom-fort, 1 patient had dizziness, and the incidence of adverse reactions was 11.43%(4/35). The incidence of adverse reactions in the three groups showed no significant difference(P>0.05). Conclusion: Oral antibiotics combined with prednisone can improve the clinical effica- cy in the treatment of patients with non-lactating acute mastitis, and increasing the oral dose of prednisone can further improve the clini- cal efficiency, control the inflammatory progress, and shorten the recovery time. |
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