| 刘开云,刘 欢,张 融,左丹华,黄富宏.蓝芩口服液联合阿奇霉素对支原体肺炎患儿免疫功能、血清β防御素-2、D-二聚体的影响[J].现代生物医学进展英文版,2018,(23):4527-4530. |
| 蓝芩口服液联合阿奇霉素对支原体肺炎患儿免疫功能、血清β防御素-2、D-二聚体的影响 |
| Effects of Lanqin Oral Liquid Combined with Azithromycin on the Immune Function, Serum β Defensin-2 and D-Dimer Levels of Children with Mycoplasma Pneumonia |
| Received:August 06, 2018 Revised:August 30, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.23.030 |
| 中文关键词: 蓝芩口服液 支原体肺炎 阿奇霉素 免疫功能 β防御素-2 D-二聚体 |
| 英文关键词: Lanqin oral liquid Mycoplasma pneumonia Azithromycin Immune function β defensin-2 D-dimer |
| 基金项目:江苏省自然科学基金项目（BK20130432） |
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| 中文摘要: |
| 摘要 目的：探究蓝芩口服液联合阿奇霉素治疗支原体肺炎患儿的临床疗效及对其免疫功能、血清β防御素-2、D-二聚体水平的影响。方法：选取2014年1月至2016年6月扬州大学附属医院收治的支原体肺炎患儿80例，根据随机数字法将其分为对照组和治疗组。对照组以阿奇霉素常规治疗，治疗组在阿奇霉素常规治疗基础上服用蓝芩口服液。治疗1周后，评价两组患者的临床症状，检测和比较两组免疫功能及血清β防御素-2、D-二聚体水平的变化。结果：治疗后，治疗组总有效率为95%，显著高于对照组(80%，P<0.05)。两组患儿治疗后血液中的白细胞计数均显著下降(P <0.05)，且治疗组患儿治疗前后白细胞计数下调幅度显著高于对照组(P<0.05)。两组患儿治疗后血清CD3+、CD4+、CD4+/CD8+、NK细胞水平均较治疗前显著升高(P<0.05)，且治疗组患儿治疗前后以上指标水平变化幅度均明显高于对照组(P<0.05)。治疗后，治疗组与对照组患儿血清β防御素-2水平分别上调至(562.86±45.38)pg/mL及(607.37±47.26)pg/mL，血清D-二聚体浓度分别下调至(83.28±10.46)pg/mL及(125.94±14.83)pg/mL，治疗组以上指标的变化均显著高于对照组(P<0.05)。结论：蓝芩口服液联合阿奇霉素治疗支原体肺炎患儿的疗效明显优于阿奇霉素常规治疗，且能显著改善患者的免疫功能，降低患儿血清中D-二聚体的水平、升高β防御素-2的水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect of lanqin oral solution combined with azithromycin on the immune func- tion and serum β-defensin-2 and D-dimer levels of children with mycoplasma pneumonia. Methods: From January 2014 to June 2016, eighty cases of children with mycoplasma pneumonia in Yangzhou University Hospital were divided into the control group and the treat- ment group according to the random number method. The control group was treated with azithromycin and the treatment group was treat- ed with lanling oral liquid combined with azithromycin. After one week of treatment, the clinical effect, immune function, levels of β-de- fensin-2 and D dimer were detected and compared betwen two groups. Results: After treatment, the total effective rate of treatment group was 95% , which was significantly higher than that of the control group(80%, P<0.05). After treatment, the white blood cell count in the both groups were significantly decreased(P<0.05), and the decline degree of white blood cell count in the treatment group was signifi- cantly higher than that in the control group(P<0.05). The levels of CD3+, CD4+, CD4+/CD8+ and NK cells in the serum of both groups were higher than those in the control group(P<0.05), and the serum levels of these indicators in the treatment group was higher than that in the control group(P<0.05). The serum β-defensin-2 levels in the treatment group and in the control group were increased to (607.37±47.26) pg/mL and (562.86±45.38) pg/mL, and the serum D-dimer levels were decreased to (83.28±10.46) pg/ml and (125.94±14.83) pg/mL. The reduction degree of treatment group was significantly higher than that of the control group(P<0.05). Conclusion: The effect of lan- qin oral solution combined with azithromycin on the treatment of children with mycoplasma pneumonia was better than that of azithromycin alone, it could improve the immune function of patients and reduce the serum D-dimer level and increase the serum βde- fensin-2 level. |
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