| 周文正,李祖涛,殷 剑,赵 巍,孙俊刚.滑膜炎颗粒联合玻璃酸钠治疗创伤性膝关节滑膜炎的疗效及对患者血清炎症因子水平的影响[J].现代生物医学进展英文版,2018,(23):4506-4509. |
| 滑膜炎颗粒联合玻璃酸钠治疗创伤性膝关节滑膜炎的疗效及对患者血清炎症因子水平的影响 |
| Effect of Synovitis Granule Combined with Sodium Hyaluronate on Traumatic Synovitis of Knee Joint and its Influence on Serum Inflammatory Factors Level |
| Received:May 26, 2018 Revised:June 22, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.23.025 |
| 中文关键词: 滑膜炎颗粒 玻璃酸钠 创伤性 膝关节滑膜炎 疗效 炎症因子 |
| 英文关键词: Synovitis granule Sodium hyaluronate Traumatic Synovitis of knee joint Curative effect Inflammatory factors |
| 基金项目:新疆自治区卫生计生委适宜技术推广项目（20170413A-006） |
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| 中文摘要: |
| 摘要 目的：探讨滑膜炎颗粒联合玻璃酸钠治疗创伤性膝关节滑膜炎的疗效及对患者血清炎症因子水平的影响。方法：选取2015年2月~2017年12月期间我院收治的创伤性膝关节滑膜炎患者216例为研究对象。根据随机数字表法将患者分为对照组（n=108）与研究组（n=108）。对照组患者给予玻璃酸钠治疗，研究组则在此基础上联合滑膜炎颗粒进行治疗，两组均治疗5周。比较两组治疗5周后（治疗后）的临床疗效及治疗前后血清白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白介素-1β（IL-1β）水平，采用视觉模拟量表（VAS）评价患者治疗前后膝关节疼痛程度，美国特种外科医院量表（HSS）评价患者治疗前后膝关节功能，同时观察两组治疗期间不良反应发生情况。结果：研究组患者总有效率为92.59%（100/108），高于对照组患者的78.70%（85/108）（P<0.05）。两组患者治疗后IL-6、TNF-α以及IL-1β水平均较治疗前降低，且研究组低于对照组（P<0.05）。两组患者治疗后VAS评分较治疗前降低，且研究组低于对照组，HSS评分较治疗前升高，且研究组高于对照组（P<0.05）。两组患者不良反应发生率对比差异无统计学意义（P>0.05）。结论：滑膜炎颗粒联合玻璃酸钠治疗创伤性膝关节滑膜炎安全有效，可显著改善患者血清炎症因子水平以及膝关节功能，并减轻患者疼痛程度，具有一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of synovitis granule combined with sodium hyaluronate on traumatic synovitis of knee joint and its influence on serum inflammatory factors. Methods: 216 patients with traumatic synovitis of knee joint who were treated in our hospital from February 2015 to December 2017 were selected as the research subjects. According to the number table method,the patients were randomly divided into control group(n=108) and study group(n=108). The control group was treated with sodium hyaluronate, while the study group was treated with synovitis granules. The two groups were treated for 5 weeks. The clinical efficacy of two groups at 5 weeks after treatment (after treatment) and the levels of serum interleukin -6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin -1β (IL-1β) before and after treatment, visual analogue scale (VAS) was used to evaluate the degree of knee pain before and after treatment, the American special surgery hospital scale (HSS) was used to evaluate knee function before and after treatment, mean- while, the adverse reactions of the two groups during treatment were observed. Results: The total effective rate of the study group was 92.59% (100/108), which was significantly higher than 78.70% (85/108) of the control group(P<0.05). The levels of IL-6, TNF-α and IL-1β after treatment in the two groups were lower than those before treatment, and the study group was lower than that in the control group(P<0.05). The VAS score of the two groups decreased after treatment, and the study group was lower than that of the control group, the HSS score was higher than that before treatment, and the study group was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Synovitis Granules Com- bined with sodium hyaluronate in the treatment of traumatic synovitis of knee joint is effective and safe. It can significantly improve the level of serum inflammatory factors, function of knee joint and relieve pain degree of patients, so it has certain clinical application value. |
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