| 杨 明,朱晓燕,伏飞达,王 旭,郭清华.鼓室内注射地塞米松联合盐酸氨溴索对分泌性中耳炎患者听力水平及免疫功能的影响[J].现代生物医学进展英文版,2018,(23):4489-4492. |
| 鼓室内注射地塞米松联合盐酸氨溴索对分泌性中耳炎患者听力水平及免疫功能的影响 |
| Effect of Intratincular Injection Dexamethasone Combined with Ambroxol Hydrochloride on Hearing Level and Immune Function in Patients with Secretory Otitis Media |
| Received:March 28, 2018 Revised:April 23, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.23.021 |
| 中文关键词: 地塞米松 盐酸氨溴索 分泌性中耳炎 听力水平 免疫功能 疗效 |
| 英文关键词: Dexamethasone Ambroxol hydrochloride Secretory otitis media Hearing level Immune function Curative effect |
| 基金项目:江苏省中医药科技发展项目（YB2015269） |
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| 中文摘要: |
| 摘要 目的：探讨鼓室内注射地塞米松联合盐酸氨溴索对分泌性中耳炎（SOM）患者听力水平及免疫功能的影响。方法：选取2017年5月-2017年11月期间我院收治的SOM患者240例为研究对象。根据随机数字表法将患者分为对照组（n=120）与研究组（n=120），对照组给予鼓室内注入地塞米松治疗，研究组在此基础上联合盐酸氨溴索治疗。比较两组患者临床疗效，比较两组患者治疗前后0.5KHz、1.0KHz、2.0KHz频率下的气导听力水平、鼓室压及CD4+、CD8+、CD4+/CD8+水平，同时观察两组不良反应发生情况。结果：治疗后研究组患者总有效率为86.67%（104/120），高于对照组的70.83%（85/120）（P<0.05）。两组患者治疗后0.5KHz、1.0KHz、2.0KHz的气导听力水平以及鼓室压均较治疗前升高，且研究组高于对照组（P<0.05）。两组患者治疗后CD4+、CD4+/CD8+均较治疗前升高，且研究组高于对照组（P<0.05）；两组患者治疗后CD8+较治疗前降低（P<0.05），但研究组与对照组比较无差异（P>0.05）。两组患者在治疗期间均未发生严重的不良反应。结论：地塞米松联合盐酸氨溴索治疗SOM患者疗效确切，对患者的免疫功能及听力水平均有一定的改善作用，安全性好，具有一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Intratincular injection dexamethasone combined with ambroxol hydrochloride on hearing level and immune function in patients with secretory otitis media(SOM). Methods: 240 cases of SOM patients who were treat- ed in our hospital from May 2017 to November 2017 were selected as the research object. The patients were divided into control group (n=120) and study group (n=120 group) according to the number table method. The control group was treated with intratincular injection dexamethasone, the study group was treated with ambroxol hydrochloride on this basis. The clinical efficacy of the two groups was cim- pared, The level of air conduction at 0.5 KHz, 1.0 KHz and 2.0 KHz frequencies, tympanum pressure and CD4+, CD8+ and CD4+/CD8+ levels were compared between the two groups before and after treatment, at the same time, the two groups of adverse reactions were ob- served. Results: The total effective rate of the patients in the study group was 86.67% (104/120), which was significantly higher than 70.83% (85/120) of the control group(P<0.05). The level of air conduction at 0.5 KHz, 1.0 KHz and 2.0 KHz frequencies and tympanum pressure in the two groups after treatment were higher than before treatment, and the study group was higher than that of the control group (P<0.05). The CD4+ and CD4+/ CD8+ in the two groups after treatment were higher than before treatment, and the study group was higher than that of the control group(P<0.05); the CD8+ in the two groups after treatment was lower than before treatment (P<0.05); but there was no difference between the study group and the control group(P>0.05). There was no adverse reaction in the two groups during the treatment. Conclusion: Intratincular injection dexamethasone combined with ambroxol hydrochloride is effective and safe in the treat- ment of patients with SOM, and it can improve the immune function and hearing level of patients, which has certain clinical application value. |
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