| 支小飞,华如衡,于鹏飞,钱 飞,朱建伟.腹腔镜与开腹胃癌根治术治疗胃癌患者的疗效及对免疫功能和炎性因子的影响[J].现代生物医学进展英文版,2018,(23):4443-4446. |
| 腹腔镜与开腹胃癌根治术治疗胃癌患者的疗效及对免疫功能和炎性因子的影响 |
| Effect of Laparoscopic and Open Radical Gastrectomy for Gastric Cancer in the Treatment of Gastric Cancer and its Effect on Immune Function and Inflammatory Factors |
| Received:June 15, 2018 Revised:July 11, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.23.010 |
| 中文关键词: 胃癌 腹腔镜胃癌根治术 开腹胃癌根治术 免疫功能 炎性因子 |
| 英文关键词: Gastric cancer Laparoscopic radical gastrectomy for gastric cancer Open radical gastrectomy for gastric cancer Im- mune function Inflammatory factors |
| 基金项目:国家自然科学基金青年基金项目（81702369）；中国博士后科学基金面上项目（2016M601868） |
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| 中文摘要: |
| 摘要 目的：探讨不同手术方式治疗胃癌患者的疗效及对免疫功能和炎性因子的影响。方法：选择2015年1月-2018年4月我院收治的择期行根治性切除术胃癌患者236例，根据不同的手术方式分为对照组（n=107）和实验组（n=129），对照组实施传统开腹胃癌根治术，实验组实施腹腔镜胃癌根治术。观察两组患者各项临床症状及并发症发生情况，比较两组患者术前、术后1 d、术后7 d免疫功能和炎性因子水平。结果：与对照组相比，实验组患者的手术时间明显升高，而其他临床症状指标以及并发症发生率显著下降（P<0.05），两组淋巴结清除数目比较无统计学差异（P>0.05）。两组患者术后1 d的IL-6、TNF-α、CRP水平均明显高于术前，但实验组低于对照组（P<0.05）。术后7 d，对照组IL-6、TNF-α、CRP水平仍高于术前（P<0.05），但实验组TNF-α、CRP水平与术前比较无统计学差异（P>0.05），同时实验组IL-6、TNF-α、CRP水平均显著低于对照组（P<0.05）。术后1 d、7 d，两组CD3+、CD4+、CD4+/CD8+均低于术前，CD8+高于术前，且实验组CD3+、CD4+、CD4+/CD8+高于对照组，CD8+低于对照组（P<0.05）。结论：与传统开腹胃癌根治术比较，腹腔镜胃癌根治术治疗胃癌患者疗效更好，可减轻炎性反应，对患者的免疫功能影响较小，安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: The effect of different surgical methods in the treatment of gastric cancer patients and its effect on immune function and inflammatory factors. Methods: 236 gastric cancer patients underwent radical resection in our hospital from January 2015 to April 2018 were selected, they were divided into the control group (n=107) and the experimental group (n=129) according to the different surgical methods. The control group were treated with traditional open radical gastrectomy for gastric cancer, and the experimental group were treated with laparoscopic radical gastrectomy for gastric cancer. The clinical symptoms and complications between the two groups were observed. The immune function and the levels of inflammatory factors between the two groups were compared at preoperative, postoperative 1 d, postoperative 7 d. Results: Compared with the control group, the operative time of the experimental group increased significantly, while the levels of other clinical symptoms and complications incidence decreased significantly (P<0.05). There was no sig- nificant difference in the number of lymph node clearance between the two groups (P>0.05). Postoperative 1 d, the levels of IL-6,TNF-α,CRP in the two groups were significantly higher than that preoperative, but the experimental group were lower than that in the control group(P<0.05). Postoperative 7 d, the levels of IL-6, TNF-α, CRP in the control group were still higher than that preoperative (P<0.05), but in the experimental group there was no significant difference in the level of TNF-α, CRP compared with the preoperative (P>0.05), while the levels of IL-6, TNF-α, CRP in the experimental group were significantly lower than that in the control group (P<0.05). Postop- erative 1 d, postoperative 7 d, the levels of CD3+, CD4+, CD4+/CD8+ in the two groups were lower than that preoperative, the level of CD8+ was higher than that preoperative,and the levels of CD3+, CD4+, CD4+/CD8+ in the experimental group were higher than that in the control group, the CD8+ level was lower than that in the control group(P<0.05). Conclusion: Compare with traditional open radical gas- trectomy, laparoscopic radical gastrectomy is better in treating gastric cancer, it can reduce the inflammatory response, has little influence on the immune function of patients, and it is safe and reliable. |
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