| 符永丰,黄应思,王世明,段明达,满元元,袁维秀.右美托咪定联合地佐辛用于结肠癌术后镇痛的临床效果观察[J].现代生物医学进展英文版,2018,(22):4378-4381. |
| 右美托咪定联合地佐辛用于结肠癌术后镇痛的临床效果观察 |
| Observation on the Clinical Effect of Dexmedetomidine Combined with Dezocine on Postoperative Analgesia after Resection of Colon Carcinoma |
| Received:May 27, 2018 Revised:June 23, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.22.041 |
| 中文关键词: 结肠癌 右美托咪定 地佐辛 静脉自控镇痛 |
| 英文关键词: Colorectal cancer Dexmedetomidine Dezocine Patient-controlled intravenous analgesia |
| 基金项目:海南省社会发展基金项目（SF201429） |
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| 中文摘要: |
| 摘要 目的：探讨右美托咪定和地佐辛用于结肠癌术后患者静脉自控镇痛(Patient-controlled intravenous analgesia，PCIA)的临床效果与安全性。方法：选择ASA I-II级行结肠癌根治术的82例患者并将其随机分为两组：观察组为右美托咪定联合地佐辛组，对照组为舒芬太尼组，每组41例。所有患者均行全麻手术，术后予PCIA。观察组将右美托咪定5 μg/kg、地佐辛1 mg/kg 、帕洛诺司琼0.75 mg和0.9 % 氯化钠共配制成100 mL，对照组将舒芬太尼 3 μg/kg、帕洛诺司琼0.75 mg 和0.9 % 氯化钠共配制成100 mL。两组患者镇痛泵参数相同，监测术后2、6、12、24、48 h的VAS镇痛评分和Ramsay镇静评分，同时记录主要不良反应的发生情况。结果：观察组术后24 h内各时间点的VAS评分均明显低于对照组(P＜0.05)，两组48 h的VAS评分比较差异无统计学意义。观察组患者术后12 h内的Ramsay镇静评分均明显低于对照组(P＜0.001)，两组24 h和48 h的Ramsay评分比较无统计学差异。观察组恶心呕吐的不良反应发生率较对照组明显降低(P＜0.05)，两组嗜睡、头晕、心动过缓发生率比较无统计学差异。结论：右美托咪定联合地佐辛用于结肠癌术后PCIA的镇痛效果明显优于舒芬太尼，且安全性更高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy and safety of postoperative patient-controlled intravenous analgesia (PCIA) with dexmedetomidine combined with dezocine after radical resection of colon carcinoma. Methods: 82 patients with ASA I-II undergoing radical resection of colon carcinoma were randomly divided into two groups: Dexmedetomidine combined with dezocine group (observation group) and sufentanil group (control group) with 41 cases in each group. All patients underwent general anesthesia and postoperative PCIA. The observation group was treated with dexmedetomidine 5 μg/kg dezocine 1 mg/kg, palonosetron 0.75 mg and saline to 100 mL, the control group PCIA was administered sufentanil 3 g/kg, palonosetron 0.75 mg and saline to 100 mL. The analgesic pump parameters were the same in two groups. The VAS score, Ramsay score and incidence of adverse reactions were monitored at 2, 6, 12, 24 and 48 h after surgery. Results: The VAS scores of observation group were significantly lower than the control group (P<0.05) within 24 h after surgery, the VAS score showed no statistical difference at 48h after surgery. The Ramsay sedation scores in the observation group were significantly lower than those in the control group (P < 0.001) within 12 h after surgery, but no significant difference was found in the Ramsay score between two groups at 24 h and 48 h after surgery. The incidence of nausea and vomiting of observation group was significantly lower than that in the control group (P<0.05). There was no significant difference in the incidence of drowsiness, dizziness and tachycardia between the two groups. Conclusion: Compared with sufentanil, Dexmedetomidine combined with dezocine in PCIA exhibited better effect of analgesia with higher safety in patients undergoing radical resections of colon carcinoma. |
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