| 邓 飞,郭志娟,祝国华,李文清,姚佳佳.抗-SLA/LP在自身免疫性肝炎的诊断、分型及病情评估中的应用价值[J].现代生物医学进展英文版,2018,(22):4353-4356. |
| 抗-SLA/LP在自身免疫性肝炎的诊断、分型及病情评估中的应用价值 |
| The Clinical Value of SLA/LP for the Diagnosis, Classification and Disease Assessment of Autoimmune Hepatitis |
| Received:April 10, 2018 Revised:April 30, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.22.035 |
| 中文关键词: 抗-SLA/LP 自身免疫性肝炎 诊断 分型 病情评估 |
| 英文关键词: Anti-SLA/LP Autoimmune Hepatitis Diagnosis Classification Disease Assessment |
| 基金项目:卫生部直属吴阶平医学基金会临床科研专项资助基金项目（320.6750.17357）；青海省科技计划基金项目（2017-ZJ-713） |
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| 中文摘要: |
| 摘要 目的：探讨抗-SLA/LP在自身免疫性肝炎的诊断、分型及病情评估中的应用价值。方法：选择2014年1月~2018年1月在我院诊治的自身免疫性肝炎患者82例进行回顾性分析，所有患者经组织学检查、临床症状及生化指标等综合诊断为自身免疫性肝炎，抗-SLA/LP阳性16例、抗-SLA/LP阴性66例，AIH-Ⅰ型51例、AIH-Ⅱ型15例、AIH-Ⅲ型16例。分析和比较抗-SLA/LP阴性和阳性患者的一般临床资料，抗-SLA/LP诊断AIH-Ⅲ型的灵敏度，比较抗-SLA/LP不同强度患者的临床和免疫功能相关指标。结果：抗-SLA/LP阴性和阳性患者的年龄、病程、ANA和AMA检出率无显著性差异，但抗-SLA/LP阳性患者的SMA检出率为0.00%，与抗-SLA/LP阴性患者相比具有统计学差异(P＜0.05)；抗-SLA/LP诊断AIH-Ⅲ型的灵敏度为100%，准确度为100%；抗-SLA/LP中高强度组患者的PTA和?茁2-微球蛋白水平均显著高于低强度阳性组(P＜0.05)，两组患者的免疫指标比较均无显著性差异(P＞0.05)。结论：抗-SLA/LP对AIH-Ⅲ型患者的诊断具有高度的灵敏度和准确性，且抗-SLA/LP阳性强度可在一定程度上反映患者肝脏功能，对患者病情的评估具有一定的意义。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical value of anti-SLA/LP for the diagnosis, classification and evaluation of autoimmune hepatitis(AIH). Methods: 82 patients with AIH admitted in our hospital from January 2014 to January 2014 were retrospectively analyzed. All THE patients were diagnosed by histological examination, clinical symptoms and biochemical indexes. Anti-SLA/LP(+) were found in 16 cases, anti-SLA/LP(-) were found in 66 cases. Among them, there were 51 cases of AIH-Ⅰ, 15 cases of AIH-Ⅱ and 16 cases of AIH-Ⅲ. The clinical data of patients with negative and positive anti-SLA/LP, the sensitivity and accuracy of anti-SLA/LP for the diagnosis of AIH-Ⅲ, the clinical and related parameters of immune function in patients with different degree of anti-SLA/LP were analyzed. Results: There was no significant difference in the age, course, ANA and AMA detection rate between two groups. The detection rate of SMA was 0.00% in anti-SLA/LP positive patients, there were statistical differences compared with the anti-SLA/LP negative patients(P<0.05). The sensitivity and accuracy of anti-SLA/LP for the diagnosis of AIH-Ⅲ were 100% respectively. Both PTA and β2-microglobulin levels in the high-intensity positive group were significantly higher than those in the low-intensity positive group (P<0.05), and there was no significant difference between the other clinical indicators and immune indicators between high-intensity and low-intensity positive patients (P<0.05). Conclusion: Anti-SLA/LP had high sensitivity and accuracy for the diagnosis of patients with AIH-Ⅲ, and the SLA/LP positive intensity can reflect the liver function and had certain significance for the assessment of the disease condition. |
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