| 朱朝健,曲海晶,吴东奇,金 星,于 涛.硫化铜纳米粒子在肿瘤成像与治疗中的功能研究进展[J].现代生物医学进展英文版,2018,(21):4187-4190. |
| 硫化铜纳米粒子在肿瘤成像与治疗中的功能研究进展 |
| Research Progress in the Function in Tumor Imaging and Therapy of Copper Sulfide Nanoparticles |
| Received:December 30, 2017 Revised:January 27, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.21.042 |
| 中文关键词: 硫化铜 纳米材料 肿瘤成像 肿瘤治疗 |
| 英文关键词: Copper sulfide Nanoparticles Tumor imaging Tumor therapy |
| 基金项目:中国博士后科学基金面上项目（2016M600238） |
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| 中文摘要: |
| 摘要：硫化铜是一种二价铜的硫化物，可以作为半导体材料，化学式为CuS，呈黑褐色，溶解度极低。硫化铜纳米粒子（Copper sul- fide nanoparticles, CuS NPs）是纳米尺度大小的硫化铜。近年来，CuS NPs因其结构的可塑性，良好的光热稳定性、生物相容性、突出的光热及光声转换性能，成为了当今纳米材料医学领域的研究热点，在肿瘤诊断和治疗领域中引起了广泛关注。CuS NPs本身可通过介质鳌合金属离子合成多功能纳米粒子，实现肿瘤多模式诊断，并且在光热治疗研究中体现出突出的治疗效果。本文综述了近几年CuS NPs在肿瘤诊断与治疗方面的研究进展，总结肿瘤治疗中的应用研究方法，对CuS NPs在生物医学领域应用中存在的问题进行分析，为解决实际操作过程所遇到的问题提供参考。 |
| 英文摘要: |
| ABSTRACT: Copper sulfide, a kind of sulfide of Cu2+ with black brown and low solubility, could be used as semiconductor mate- rials and the chemical formula is CuS. But many materials have different properties at nanometer scale. Copper sulfide nanoparticles (CuS NPs) are nano-sized copper sulfide. In recent years, CuS NPs have become the researchful focus in the field of nanomedicine and attracted widely attention in the field of tumor diagnosis and treatment due to the plasticity of structure, well photothermal stability, bio- compatibility, and outstanding photothermal and photoacoustic conversion properties. CuS NPs could synthesize multifunctional nanoparticles through chelating metal ions to achieve multi-mode diagnosis of tumor and show prominent therapeutic effect in photother- mal therapy. This paper reviews the research progress of CuS NPs in diagnosis and treatment of tumor in recent years, summarizes the ap- plication methods of tumor treatment, and analyzes the existing problems in the application of CuS NPs in the biomedical field, which provides reference for solving the problems in actual operation process. |
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