| 董春萍,吴贵福,张瑜庆,高 珊,何 岚.肥胖2型糖尿病患者血清脂联素、E-选择素、可溶性细胞黏附因子-1的表达及其与氧化应激的关系[J].现代生物医学进展英文版,2018,(21):4164-4168. |
| 肥胖2型糖尿病患者血清脂联素、E-选择素、可溶性细胞黏附因子-1的表达及其与氧化应激的关系 |
| Expressions of Serum Adiponectin, E-selectin and Soluble Cell Adhesion Molecule-1 of Obese Patients with Type 2 Diabetes Mellitus and the Relationship with Oxidative Stress |
| Received:February 24, 2018 Revised:March 18, 2018 |
| DOI：10.13241/j.cnki.pmb.2018.21.037 |
| 中文关键词: 肥胖2型糖尿病 血清脂联素 E-选择素 可溶性细胞黏附因子-1 氧化应激 |
| 英文关键词: Obesity type 2 diabetes mellitus Serum adiponectin E-selectin Soluble cell adhesion factor-1 Oxidative stress |
| 基金项目:陕西省自然科学基金项目（2012SF2-19） |
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| 中文摘要: |
| 摘要 目的：研究肥胖2型糖尿病患者血清脂联素、E-选择素、可溶性细胞黏附因子-1的表达及其与氧化应激的关系。方法：选择2015年06月至2017年01月在我院治疗的2型糖尿病患者72名，根据患者体重和腰围分为观察组与对照组，观察组为肥胖2型糖尿病患者，对照组为非肥胖2型糖尿病患者。分析两组患者临床指标检测结果及与氧化应激的相关性。结果：观察组血清脂联素(Adiponectin，ADPN)、超氧化物歧化酶(Superoxide Dismutase，SOD)水平[(6.05±1.01) μg/ml vs(7.83±1.25) μg/ml、(72.15±12.04)NU/ml vs(87.66±14.53) NU/ml]均明显低于对照组水平，且观察组E-选择素(Human soluble E-selectin, sE-selectin)、丙二醛(Malondialdehyde; malonic dialdehyde; Propanedial, MDA)、可溶性血管细胞黏附因子-1(Human soluble vasccular cell adhesion molecule 1, sVCAM-1)、HOMA-胰岛素抵抗指数(Homeostasis model assessment for insulin resistance, HOMA-IR)水平[(66.81±11.10) μg/L vs(55.22±9.05) μg/L、(5.68±0.92)μmol/L vs(4.15±0.62) μmol/L、(1.84±0.25) mg/L vs(1.70±0.24) mg/L、(4.52±1.88) vs(2.23±1.15)]均明显高于对照组(P<0.05)；观察组患者甘油三酯(Triglyceride,TG)、胆固醇( total cholesterol, TC)、低密度脂蛋白胆固醇(Low-density lipoprotein, LDL-C)显著高于对照组，高密度脂蛋白胆固醇(High-density lipoprotein cholesterol, HDL-C)、糖化血红蛋白(Hemoglobin A1C, HbA1C)明显低于对照组(P<0.05)。MDA与空腹血糖(fasting plasma glucose, FPG)、餐后2小时血糖( 2 hours postprandial blood glucose, 2Hpg)、HbA1C、TG、TC、LDL-C、sE-selectin、sVCAM-1、HOMA-IR呈正相关关系(P<0.05)，与HDL3-C、ADPN、SOD呈负相关关系(P<0.05)；SOD与FPG、2Hpg、HbA1C、TG、TC、LDL-C、sE-selectin、sVCAM-1、HOMA-IR、MDA呈负相关关系(P<0.05)，与HDL3-C、ADPN呈正相关关系(P<0.05)。结论：肥胖易导致2型糖尿病患者的血清脂联素下降并抑制胰岛素的分泌，可溶性血管细胞黏附分子-1及E-选择素的高表达与肥胖2型糖尿病患者发生氧化应激有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expressions of serum adiponectin, E-selectin and soluble cell adhesion molecule-1 of obese pa- tients with type 2 diabetes mellitus and their relationship with oxidative stress. Methods: 72 cases of patients with type 2 diabetes mellitus treated from June 2015 to January 2017 were selected and divided into the control group and the observation group according to weight and waist circumference. The observation group was obese patients with type 2 diabetes, the control group was non-obese patients with type 2 diabetes. The clinical data of patients in two groups were analyzed. Results: The ADPN, SOD of observation group [(6.05±1.01) μg/ml vs(7.83±1.25) μg/ml; (72.15±12.04)NU/ml vs(87.66±14.53) NU/ml] were significantly lower than those of the control group level, the serum sE-selectin, MDA, sVCAM-1, HOMA-insulin resistance index level[(66.81±11.10) μg/L vs(55.22±9.05) μg/L;(5.68±0.92)μmol/L vs(4.15±0.62) μmol/L; (1.84±0.25) mg/L vs(1.70±0.24) mg/L); (4.52±1.88) vs(2.23±1.15)] of observation group were significantly higher than those of the control group(P<0.05). The levels of TG, TC and LDL-C in the observation group were significantly higher than those in the control group, and the HDL3-C and HbA1C in the observation group were significantly lower than those in the control group (P<0.05). MDA was positively correlated with FPG, 2Hpg, HbA1C, TG, TC, LDL-C, sE-selectin, sVCAM-1 and HOMA-IR(P<0.05) and negatively correlated with HDL3-C, ADPN , SOD(P<0.05); SOD was positively correlated with FPG, 2Hpg, HbA1C, TG, TC, LDL-C, sE-selectin, sVCAM-1, HOMA-IR and MDA and negatively correlated with HDL3-C、ADPN(P<0.05). Conclusion: Obesity can lead to the decline of serum adiponectin level of patients with type 2 diabetes mellitus and inhibit the secretion of in- sulin. The high expression of soluble vascular cell adhesion molecule-1 and E-selectin may cause oxidative stress in the patients with type 2 diabetes mellitus. |
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